Macromolecular Poly(N‐isopropylacrylamide) (PNIPAM) in Cancer Treatment and Beyond
Advances in Polymer Technology,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Poly(N‐isopropylacrylamide)
(PNIPAM)
is
a
versatile
polymer
known
for
its
phase
transition
properties,
exhibiting
lower
critical
solution
temperature
(LCST)
of
approximately
32°C.
Below
this
temperature,
PNIPAM
hydrophilic,
while
above
it,
the
becomes
hydrophobic,
making
it
ideal
thermosensitive
drug
delivery
systems
(DDSs).
In
tissue
engineering,
provides
biocompatible,
nontoxic
and
stimuli‐responsive
surface
cell
culture.
Its
nature
ensures
safety
in
medical
applications.
enhances
biosensing
diagnostics
through
affinity
biomolecules,
improving
accuracy.
Widely
used
hydrogels,
smart
textiles,
soft
robotics
various
applications,
adapts
to
environmental
changes.
straightforward
synthesis
allows
creation
diverse
copolymers
composites,
applicable
selective
reactions
conjugations
with
fluorescent
tags
or
chemical
modifications.
PNIPAM’s
versatility
extends
pH‐responsive
alternatives,
broadening
application
spectrum.
Practical
examples
include
separation
water
treatment
cleaning
processes.
This
discussion
explores
biomedical
particularly
cancer
treatment,
photothermal
therapy
(PTT)
photodynamic
(PDT),
gene
imaging.
Additionally,
highlights
noncancerous
such
as
small
interfering
RNA
(siRNA)
targeting
oncogenes
detailed
imaging
deep
tumour
tissues.
Язык: Английский
Autocatalytic Artesunate Coordinated ZIF-8 Nanoplatforms with Metal-Polyphenol Network Coating for Targeted Tumor Chemodynamic Therapy
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(7), С. 7731 - 7742
Опубликована: Март 27, 2024
Artesunate
(Art)
with
a
unique
peroxy-bridging
bond
can
react
ferrous
ion
and
produce
excess
carbon-centered
radicals,
which
cause
irreversible
damage
to
tumor
cells.
However,
the
antitumor
effect
of
artesunate
still
faces
challenges
due
its
poor
water
solubility
insufficient
amount
ions
in
Herein,
we
constructed
coordinated
zeolite
imidazole
framework
nanoplatforms
(Art/ZIF
NPs)
coated
ferric
ion-rutin
network
(Ru–Fe@Art/ZIF
for
synergy
therapy.
In
virtue
zinc-ion-mediated
coordination,
Art
was
efficiently
loaded
into
ZIF-8
NPs
(loading
capacity
rate
are
29.58
30.73%)
responsively
released
under
an
acidic
environment.
Meanwhile,
introduction
rutin
(a
type
plant
flavonoid)
not
only
enabled
targeting
via
GLUT
receptors
but
also
reduced
Fe3+
Fe2+
conditions.
Subsequently,
these
loading
enhance
killing
radical-dependent
cell
cycle
arrest.
This
"core–shell"
autocatalytic
nanoplatform
provides
novel
strategy
developing
Art-based
chemodynamic
Язык: Английский
Reactive oxygen species responsive dextran-thioketal conjugate nanocarriers for the delivery of hydrophilic payloads
Carbohydrate Polymers,
Год журнала:
2025,
Номер
356, С. 123375 - 123375
Опубликована: Фев. 13, 2025
Язык: Английский
Enhanced Anticancer Effects of Intratumorally Injected Electrostatic Doxorubicin‐Loaded Click‐Type Crosslinked Hyaluronic Acid Hydrogel
Advanced Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 2, 2024
Abstract
Injectable
depots
have
received
increasing
notoriety
as
local
drug
delivery
vehicles
for
tumor
treatment.
Here,
an
intratumoral
formulation
of
doxorubicin
(Dox)
is
proposed
that
relies
on
the
electrostatic
interaction
between
carboxylic
group
click‐type
crosslinked
hyaluronic
acid
(Cx‐HA)
and
cationic
Dox
to
achieve
effective
The
Dox‐loaded
HA
(Cx‐HA‐Dox)
exhibits
adequate
injectability
injection
rapidly
forms
a
depot
at
site,
remaining
inside
over
18
days.
This
enhances
bioavailability
therapeutic
efficacy
primarily
within
tumor,
minimizing
off‐target
side
effects.
Intratumoral
Cx‐HA‐Dox
in
animal
models
significantly
suppresses
growth,
evidenced
by
decrease
volume
time.
Histological
analysis
reveals
limited
angiogenesis
treated
tumors
increase
number
large
apoptotic
cells.
Overall,
findings
suggest
electrostatically
can
synergistically
enhance
anticancer
activity
Dox.
Язык: Английский