Enhanced Anticancer Effects of Intratumorally Injected Electrostatic Doxorubicin‐Loaded Click‐Type Crosslinked Hyaluronic Acid Hydrogel DOI
Hyeon Jin Ju, Min Ju Kim, Shina Kim

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Injectable depots have received increasing notoriety as local drug delivery vehicles for tumor treatment. Here, an intratumoral formulation of doxorubicin (Dox) is proposed that relies on the electrostatic interaction between carboxylic group click‐type crosslinked hyaluronic acid (Cx‐HA) and cationic Dox to achieve effective The Dox‐loaded HA (Cx‐HA‐Dox) exhibits adequate injectability injection rapidly forms a depot at site, remaining inside over 18 days. This enhances bioavailability therapeutic efficacy primarily within tumor, minimizing off‐target side effects. Intratumoral Cx‐HA‐Dox in animal models significantly suppresses growth, evidenced by decrease volume time. Histological analysis reveals limited angiogenesis treated tumors increase number large apoptotic cells. Overall, findings suggest electrostatically can synergistically enhance anticancer activity Dox.

Language: Английский

Macromolecular Poly(N‐isopropylacrylamide) (PNIPAM) in Cancer Treatment and Beyond DOI Creative Commons

Siddhi Throat,

Sankha Bhattacharya

Advances in Polymer Technology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Poly(N‐isopropylacrylamide) (PNIPAM) is a versatile polymer known for its phase transition properties, exhibiting lower critical solution temperature (LCST) of approximately 32°C. Below this temperature, PNIPAM hydrophilic, while above it, the becomes hydrophobic, making it ideal thermosensitive drug delivery systems (DDSs). In tissue engineering, provides biocompatible, nontoxic and stimuli‐responsive surface cell culture. Its nature ensures safety in medical applications. enhances biosensing diagnostics through affinity biomolecules, improving accuracy. Widely used hydrogels, smart textiles, soft robotics various applications, adapts to environmental changes. straightforward synthesis allows creation diverse copolymers composites, applicable selective reactions conjugations with fluorescent tags or chemical modifications. PNIPAM’s versatility extends pH‐responsive alternatives, broadening application spectrum. Practical examples include separation water treatment cleaning processes. This discussion explores biomedical particularly cancer treatment, photothermal therapy (PTT) photodynamic (PDT), gene imaging. Additionally, highlights noncancerous such as small interfering RNA (siRNA) targeting oncogenes detailed imaging deep tumour tissues.

Language: Английский

Citations

11
Reactive oxygen species responsive dextran-thioketal conjugate nanocarriers for the delivery of hydrophilic payloads DOI

Sourav Nayak,

Nuran Caz,

Elien Derveaux

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 356, P. 123375 - 123375

Published: Feb. 13, 2025

Language: Английский

Citations

0
Autocatalytic Artesunate Coordinated ZIF-8 Nanoplatforms with Metal-Polyphenol Network Coating for Targeted Tumor Chemodynamic Therapy DOI
Lirong Zhang, Beibei Yu, Zijian Zhuang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 7731 - 7742

Published: March 27, 2024

Artesunate (Art) with a unique peroxy-bridging bond can react ferrous ion and produce excess carbon-centered radicals, which cause irreversible damage to tumor cells. However, the antitumor effect of artesunate still faces challenges due its poor water solubility insufficient amount ions in Herein, we constructed coordinated zeolite imidazole framework nanoplatforms (Art/ZIF NPs) coated ferric ion-rutin network (Ru–Fe@Art/ZIF for synergy therapy. In virtue zinc-ion-mediated coordination, Art was efficiently loaded into ZIF-8 NPs (loading capacity rate are 29.58 30.73%) responsively released under an acidic environment. Meanwhile, introduction rutin (a type plant flavonoid) not only enabled targeting via GLUT receptors but also reduced Fe3+ Fe2+ conditions. Subsequently, these loading enhance killing radical-dependent cell cycle arrest. This "core–shell" autocatalytic nanoplatform provides novel strategy developing Art-based chemodynamic

Language: Английский

Citations

3
Enhanced Anticancer Effects of Intratumorally Injected Electrostatic Doxorubicin‐Loaded Click‐Type Crosslinked Hyaluronic Acid Hydrogel DOI
Hyeon Jin Ju, Min Ju Kim, Shina Kim

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Injectable depots have received increasing notoriety as local drug delivery vehicles for tumor treatment. Here, an intratumoral formulation of doxorubicin (Dox) is proposed that relies on the electrostatic interaction between carboxylic group click‐type crosslinked hyaluronic acid (Cx‐HA) and cationic Dox to achieve effective The Dox‐loaded HA (Cx‐HA‐Dox) exhibits adequate injectability injection rapidly forms a depot at site, remaining inside over 18 days. This enhances bioavailability therapeutic efficacy primarily within tumor, minimizing off‐target side effects. Intratumoral Cx‐HA‐Dox in animal models significantly suppresses growth, evidenced by decrease volume time. Histological analysis reveals limited angiogenesis treated tumors increase number large apoptotic cells. Overall, findings suggest electrostatically can synergistically enhance anticancer activity Dox.

Language: Английский

Citations

0