Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections

Chemical Society Reviews, Год журнала: 2021, Номер 50(15), С. 8762 - 8789

Опубликована: Янв. 1, 2021

Photothermal therapy (PTT)-derived multimodal synergistic treatments exhibit a super-additive effect in fighting bacterial infections.

Язык: Английский

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Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination

ACS Nano, Год журнала: 2020, Номер 14(3), С. 3546 - 3562

Опубликована: Фев. 18, 2020

Photothermal treatment (PTT) involving a combination of therapeutic modalities recently emerged as an efficient alternative for combating biofilm. However, PTT-related local high temperature may destroy the surrounding healthy tissues. Herein, we present all-in-one phototherapeutic nanoplatform consisting l-arginine (l-Arg), indocyanine green (ICG), and mesoporous polydopamine (MPDA), namely, AI-MPDA, to eliminate already-formed The fabrication process included surface modification MPDA with l-Arg further adsorption ICG via π–π stacking. Under near-infrared (NIR) exposure, AI-MPDA not only generated heat but also produced reactive oxygen species, causing cascade catalysis release nitric oxide (NO). NIR irradiation, biofilm elimination was attributed NO-enhanced photodynamic therapy low-temperature PTT (≤45 °C). Notably, NIR-triggered strategy resulted in severe destruction bacterial membranes. displayed good cytocompatibility. NIR-irradiated nanoparticles prevented colonization realized rapid recovery infected wounds. More importantly, platform effective efficiency around 100% abscess formation model. Overall, this provides reliable tool biofilms clinical applications.

Язык: Английский

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Interfacial engineering of Bi2S3/Ti3C2Tx MXene based on work function for rapid photo-excited bacteria-killing

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Фев. 22, 2021

Abstract In view of increasing drug resistance, ecofriendly photoelectrical materials are promising alternatives to antibiotics. Here we design an interfacial Schottky junction Bi 2 S 3 /Ti C T x resulting from the contact potential difference between Ti and . The different work functions induce formation a local electrophilic/nucleophilic region. self-driven charge transfer across interface increases electron density on formed barrier inhibits backflow electrons boosts separation. photocatalytic activity intensively improved amount reactive oxygen species under 808 nm near-infrared radiation. They kill 99.86% Staphylococcus aureus 99.92% Escherichia coli with assistance hyperthermia within 10 min. We propose theory engineering based function accordingly photoresponsive using two kinds components effectively eradicate bacterial infection.

Язык: Английский

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Defect‐Rich Adhesive Molybdenum Disulfide/rGO Vertical Heterostructures with Enhanced Nanozyme Activity for Smart Bacterial Killing Application

Advanced Materials, Год журнала: 2020, Номер 32(48)

Опубликована: Окт. 28, 2020

Abstract Nanomaterials with intrinsic enzyme‐like activities, namely “nanozymes,” are showing increasing potential as a new type of broad‐spectrum antibiotics. However, their feasibility is still far from satisfactory, due to low catalytic activity, poor bacterial capturing capacity, and complicated material design. Herein, facile synthesis defect‐rich adhesive molybdenum disulfide (MoS 2 )/rGO vertical heterostructure (VHS) through one‐step microwave‐assisted hydrothermal method reported. This simple, convenient but effective for rapid enables extremely uniform well‐dispersed MoS /rGO VHS abundant S Mo vacancies rough surface, performance approaching the requirements practical application. It demonstrated experimentally theoretically that as‐prepared possesses defect irradiation dual‐enhanced triple activities (oxidase, peroxidase, catalase) promoting free‐radical generation, owing much more active edge sites exposure. Meanwhile, VHS‐achieved surface exhibits excellent capacity capture, elevated reactive oxygen species (ROS) destruction local topological interactions. As result, optimized efficacy against drug‐resistant Gram‐negative Gram‐positive bacteria can be explored by such nanozymes, demonstrating simple powerful way engineered nanozymes alternative

Язык: Английский

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Highly Effective and Noninvasive Near‐Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

Advanced Science, Год журнала: 2019, Номер 6(17)

Опубликована: Июль 19, 2019

Abstract Biofilms have been related to the persistence of infections on medical implants, and these cannot be eradicated because resistance biofilm structures. Therefore, a biocompatible phototherapeutic system is developed composed MoS 2 , IR780 photosensitizer, arginine–glycine–aspartic acid–cysteine (RGDC) safely eradicate biofilms titanium implants within 20 min. The magnetron‐sputtered film possesses excellent photothermal properties, can produce reactive oxygen species (ROS) with irradiation near‐infrared (NIR, λ = 700–1100 nm) light. Consequently, combination therapy (PTT) photodynamic (PDT), assisted by glutathione oxidation accelerated NIR light, provide synergistic rapid killing bacteria, i.e., 98.99 ± 0.42% eradication ratio against Staphylococcus aureus in vivo min, which much greater than that PTT or PDT alone. With assistance ROS, permeability damaged bacterial membranes increases, become more sensitive heat, thus accelerating leakage proteins from bacteria. In addition, RGDC biosafety osteoconductivity, confirmed animal experiments.

Язык: Английский

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Well-Defined Gold Nanorod/Polymer Hybrid Coating with Inherent Antifouling and Photothermal Bactericidal Properties for Treating an Infected Hernia

ACS Nano, Год журнала: 2020, Номер 14(2), С. 2265 - 2275

Опубликована: Фев. 4, 2020

Biomedical device-associated infection (BAI) is a great challenge in modern clinical medicine. Therefore, developing efficient antibacterial materials significantly important and meaningful for the improvement of medical treatment people's health. In present work, we developed strategy surface functionalization multifunctional applications. A functionalized polyurethane (PU, widely used biomedical material hernia repairing) (PU-Au-PEG) with inherent antifouling photothermal bactericidal properties was readily prepared based on near-infrared (NIR)-responsive organic/inorganic hybrid coating which consists gold nanorods (Au NRs) polyethylene glycol (PEG). The PU-Au-PEG showed high efficiency to resist adhesion bacteria exhibited effective under 808 nm NIR irradiation, especially against multidrug-resistant bacteria. Furthermore, could inhibit biofilm formation long term. biocompatibility also proved by cytotoxicity hemolysis tests. vivo were first verified subcutaneous implantation animal model. Then, anti-infection performance scenario studied an infected results experiment studies demonstrated excellent performances PU-Au-PEG. work provides facile promising approach develop devices.

Язык: Английский

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Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives

Theranostics, Год журнала: 2019, Номер 10(2), С. 757 - 781

Опубликована: Дек. 6, 2019

The marked augment of drug-resistance to traditional antibiotics underlines the crying need for novel replaceable antibacterials.Research advances have revealed considerable sterilization potential two-dimension graphene-based nanomaterials.Subsequently, two-dimensional nanomaterials beyond graphene (2D NBG) as antibacterials also demonstrated their power disinfection due unique physicochemical properties and good biocompatibility.Therefore, exploration antibacterial mechanisms 2D NBG is vital manipulate future applications.Herein, we summarize recent research progress NBG-based agents, starting with a detailed introduction relevant mechanisms, including direct contact destruction, oxidative stress, photo-induced antibacterial, control drug/metallic ions releasing, multi-mode synergistic antibacterial.Then, effect on activities discussed.Additionally, summary different kinds given, such transition-metal dichalcogenides/oxides, metal-based compounds, nitride-based nanomaterials, black phosphorus, transition metal carbides, nitrides.Finally, rationally analyze current challenges new perspectives study more effective agents.This review not only can help researchers grasp status antibacterials, but may catalyze breakthroughs in this fast-growing field.

Язык: Английский

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Niobium Carbide MXene Augmented Medical Implant Elicits Bacterial Infection Elimination and Tissue Regeneration

ACS Nano, Год журнала: 2020, Номер 15(1), С. 1086 - 1099

Опубликована: Дек. 29, 2020

Incurable bacterial infections, impenetrable microbial biofilm, and irreversible antibiotic resistance are among the most dangerous threats for humans. With few effective strategies available in antimicrobial antibiofilm development, innovative methodologies inspired by advances other fields such as nanomedicine becoming more attractive to realize antibacterial agents. Herein, a 2D niobium carbide (Nb2C) MXene titanium plate (Nb2C@TP)-based clinical implant with practical multimodal anti-infection functions was developed. Such emerging modes capable of destroying biofilms direct bacteria elimination through down-regulating energy metabolism pathways, suppressing biofilm formation, enhancing as-formed detachment via an activating accessory gene regulator. Another intriguing feature this is sensitization ability toward photothermal transduction, which reduces temperature necessary eradication mitigates possible normal tissue damage. Moreover, Nb2C@TP medical able alleviate proinflammatory responses scavenging excessive reactive oxygen species infectious microenvironments, benefiting angiogenesis remodeling.

Язык: Английский

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Recent Progress in Photocatalytic Antibacterial

ACS Applied Bio Materials, Год журнала: 2021, Номер 4(5), С. 3909 - 3936

Опубликована: Янв. 7, 2021

Pathogens on wounds and infected tissues or pathogens in drinking water public facilities have been doing great harm human life. Because of booming drug resistance superbacteria, the abuse excessive use antibiotics during systemic treatment has caused a global antibiotic crisis. However, it usually takes long time to develop antibiotics. In recent years, photocatalytic antibacterial agents no side-effects due their rapid efficient bactericidal efficacy. They are becoming one most hopeful substitutions for dealing with bacterial diseases pollution by certain pathogens. Photocatalysis unique advantages field antibacterials, its controllability plays an irreplaceable role. This review focuses mechanism photocatalysis, which involves representative semiconductors (metal oxides, metal sulfides, carbon nitride, heterojunction composite materials) organics (organic polymers organic small molecules-aggregation induced emission) as well mechanism. this paper, we summarize mechanisms numbers current developing antimicrobial materials applications. Current difficulties expectations future these fields presented stimulate material manufacturing technologies industrialization combat infections. addition, potential application limitations research highlighted.

Язык: Английский

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Innovative Strategies Toward the Disassembly of the EPS Matrix in Bacterial Biofilms

Frontiers in Microbiology, Год журнала: 2020, Номер 11

Опубликована: Май 26, 2020

Bacterial biofilms represent a major concern at worldwide level due to the high demand for implantable medical devices and rising numbers of bacterial resistance. The complex structure extracellular polymeric substances (EPS) matrix plays role in this phenomenon, since it protects bacteria from antibiotics, avoiding drug penetration bactericidal concentrations. Besides, promotes cells adopt dormant lifestyle, becoming less susceptible antibacterial agents. Currently, available treatment biofilm-related infections consists administration conventional antibiotics doses long-term period. However, lacks efficiency against mature implant-associated may be necessary remove device. Thus, an economical burden healthcare systems. New strategies focusing on are being highlighted as alternative therapies eradicate biofilms. Here, we outline reported disruptive agents, nanocarriers, technologies, such application magnetic fields, photodynamic therapy, ultrasounds, that have been under investigation disrupt EPS clinically relevant In ideal synergistic effect between explored innovated is aimed completely avoid antimicrobial resistance phenomena.

Язык: Английский

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