Advanced Materials,
Год журнала:
2023,
Номер
35(31)
Опубликована: Июнь 7, 2023
Abstract
Due
to
the
emergence
of
drug
resistance
in
bacteria
and
biofilm
protection,
achieving
a
satisfactory
therapeutic
effect
for
bacteria‐infected
open
wounds
with
conventional
measures
is
problematic.
Here,
photothermal
cascade
nano‐reactor
(CPNC@GOx‐Fe
2+
)
constructed
through
supramolecular
strategy
hydrogen
bonding
coordination
interactions
between
chitosan‐modified
palladium
nano‐cube
(CPNC),
glucose
oxidase
(GOx),
ferrous
iron
(Fe
).
CPNC@GOx‐Fe
exhibits
excellent
effects
powers
GOx‐assisted
reaction
generate
hydroxyl
radicals,
enabling
chemodynamic
combination
therapy
against
biofilms.
Further
proteomics,
metabolomics,
all‐atom
simulation
results
indicate
that
damage
radical
function
structure
cell
membrane
thermal
enhance
fluidity
inhomogeneity
bacterial
membrane,
resulting
synergistic
antibacterial
effect.
In
biofilm‐associated
tooth
extraction
wound
model,
generated
from
process
can
initiate
polymerization
form
hydrogel
situ
protection.
vivo
experiments
confirm
protection
accelerate
healing
infected
tooth‐extraction
without
affecting
oral
commensal
microbiota.
This
study
provides
way
propose
multifunctional
system
treatment
infection.
Chemical Reviews,
Год журнала:
2023,
Номер
123(11), С. 6891 - 6952
Опубликована: Май 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
ACS Nano,
Год журнала:
2021,
Номер
15(12), С. 18895 - 18930
Опубликована: Дек. 6, 2021
Light
is
an
attractive
tool
that
has
a
profound
impact
on
modern
medicine.
Particularly,
light-based
photothermal
therapy
(PTT)
and
photodynamic
(PDT)
show
great
application
prospects
in
the
prevention
of
wound
infection
promoting
healing.
In
addition,
hydrogels
have
shown
advantages
field
dressings
due
to
their
excellent
biochemical
effects.
Therefore,
multifunctional
photoresponsive
(MPRHs)
integrate
light
are
increasingly
used
biomedicine,
especially
repair.
However,
comprehensive
review
MPRHs
for
regeneration
still
lacking.
This
first
focuses
various
types
prepared
by
diverse
photosensitizers,
agents
(PHTAs)
including
transition
metal
sulfide/oxides
nanomaterials,
nanostructure-based
PHTAs,
carbon-based
conjugated
polymer
or
complex-based
and/or
(PHDAs)
such
as
ZnO-based,
black-phosphorus-based,
TiO2-based,
small
organic
molecule-based
PHDAs.
We
also
then
discuss
how
PTT,
PDT,
photothermal/photodynamic
synergistic
can
modulate
microenvironments
bacteria
inhibit
infection.
Overall,
with
both
therapeutic
tissue
capabilities
been
discussed
existing
challenges,
well
future
research
directions
management
argued.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(9), С. 3324 - 3340
Опубликована: Янв. 1, 2022
This
tutorial
review
highlights
the
concept
and
significance
of
antibacterial
phototherapy.
Recent
developments,
advantages,
challenges
organic
photosensitizers
in
this
area
are
also
discussed.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(12), С. 4996 - 5041
Опубликована: Янв. 1, 2022
This
review
systematically
summarizes
the
research
status,
challenges,
prospects,
and
potential
bench-to-bedside
translation
of
minimally
invasive
nanomedicines.
Carbon
dots
(CDs),
comprising
crystalline
graphitized
carbon
cores
and
polymer
surface
groups,
are
currently
attracting
a
lot
of
interest
in
biological
fields
owing
to
their
fluorescent
properties,
high
photostability,
biocompatibility
low
toxicity.
In
addition,
the
easy
preparation
functionalization
CDs
stimulate
development
CDs‐based
composite
materials
with
specific
functions.
Presently,
applications
growing
at
remarkable
speed,
justifying
need
for
up‐to‐date
review
articles
that
capture
recent
progress
this
blossoming
field.
review,
breakthroughs
synthesis,
modification,
optical
toxicology
biocatalytic
platforms
described.
Further,
research
related
bioimaging,
biosensing,
drug
delivery,
antibacterial,
anticancer
(photothermal
therapy,
photodynamic
therapy
synergistic
therapy)
antiviral
therapies
involving
discussed
detail.
Finally,
perspective
on
prospects
challenges
biomedicine
biotechnology
is
provided.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Abstract
The
treatment
of
diabetic
wounds
remains
challenging
due
to
the
excess
levels
oxidative
stress,
vulnerability
bacterial
infection,
and
persistent
inflammation
response
during
healing.
development
hydrogel
wound
dressings
with
ideal
anti‐inflammation,
antioxidant,
anti‐infective
properties
is
an
urgent
clinical
requirement.
In
present
study,
injectable
thermosensitive
niobium
carbide
(Nb
2
C)‐based
C@Gel)
antioxidative
antimicrobial
activity
developed
promote
Nb
C@Gel
system
composed
C
a
PLGA‐PEG‐PLGA
triblock
copolymer.
fabricated
nanosheets
(NSs)
show
good
biocompatibility
in
vitro
cytotoxicity
hemocompatibility
assays
vivo
toxicity
assays.
experiments
that
NSs
can
efficiently
eliminate
reactive
oxygen
species
(ROS),
thus
protecting
cells
from
stress
damage.
Meanwhile,
also
exhibit
near‐infrared
(NIR)
photothermal
against
both
Staphylococcus
aureus
Escherichia
coli
.
results
demonstrate
promotes
healing
by
attenuating
ROS
levels,
reducing
damage,
eradicating
infection
under
NIR
irradiation,
accelerating
angiogenesis.
To
summarize,
system,
its
ROS‐scavenging,
hemostatic
activities,
be
promising
effective
strategy
for
wounds.
Nano-Micro Letters,
Год журнала:
2022,
Номер
14(1)
Опубликована: Авг. 24, 2022
The
pernicious
bacterial
proliferation
and
emergence
of
super-resistant
bacteria
have
already
posed
a
great
threat
to
public
health,
which
drives
researchers
develop
antibiotic-free
strategies
eradicate
these
fierce
microbes.
Although
enormous
achievements
been
achieved,
it
remains
an
arduous
challenge
realize
efficient
sterilization
cut
off
the
drug
resistance
generation.
Recently,
photothermal
therapy
(PTT)
has
emerged
as
promising
solution
efficiently
damage
integrity
pathogenic
based
on
hyperthermia
beyond
their
tolerance.
Until
now,
numerous
agents
studied
for
antimicrobial
PTT.
Among
them,
MXenes
(a
type
two-dimensional
transition
metal
carbides
or
nitrides)
are
extensively
investigated
one
most
candidates
due
high
aspect
ratio,
atomic-thin
thickness,
excellent
performance,
low
cytotoxicity,
ultrahigh
dispersibility
in
aqueous
systems.
Besides,
application
scenarios
using
antibacterial
properties
can
be
tailored
via
elaborated
designs
MXenes-based
materials.
In
this
review,
synthetic
approaches
textural
systematically
presented
first,
then
mechanisms
materials
documented.
Subsequently,
recent
progress
diverse
fields
making
use
performances
well
summarized
reveal
potential
applications
various
purposes,
including
vitro
vivo
sterilization,
solar
water
evaporation
purification,
flexible
fabrics.
Last
but
not
least,
current
challenges
future
perspectives
discussed
provide
theoretical
guidance
fabrication
systems
MXenes.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
