Tailored Hydrogel Delivering Niobium Carbide Boosts ROS‐Scavenging and Antimicrobial Activities for Diabetic Wound Healing

Small, Год журнала: 2022, Номер 18(27)

Опубликована: Июнь 9, 2022

Abstract The treatment of diabetic wounds remains challenging due to the excess levels oxidative stress, vulnerability bacterial infection, and persistent inflammation response during healing. development hydrogel wound dressings with ideal anti‐inflammation, antioxidant, anti‐infective properties is an urgent clinical requirement. In present study, injectable thermosensitive niobium carbide (Nb 2 C)‐based C@Gel) antioxidative antimicrobial activity developed promote Nb C@Gel system composed C a PLGA‐PEG‐PLGA triblock copolymer. fabricated nanosheets (NSs) show good biocompatibility in vitro cytotoxicity hemocompatibility assays vivo toxicity assays. experiments that NSs can efficiently eliminate reactive oxygen species (ROS), thus protecting cells from stress damage. Meanwhile, also exhibit near‐infrared (NIR) photothermal against both Staphylococcus aureus Escherichia coli . results demonstrate promotes healing by attenuating ROS levels, reducing damage, eradicating infection under NIR irradiation, accelerating angiogenesis. To summarize, system, its ROS‐scavenging, hemostatic activities, be promising effective strategy for wounds.

Язык: Английский

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Recent Advancements on Photothermal Conversion and Antibacterial Applications over MXenes-Based Materials

Nano-Micro Letters, Год журнала: 2022, Номер 14(1)

Опубликована: Авг. 24, 2022

The pernicious bacterial proliferation and emergence of super-resistant bacteria have already posed a great threat to public health, which drives researchers develop antibiotic-free strategies eradicate these fierce microbes. Although enormous achievements been achieved, it remains an arduous challenge realize efficient sterilization cut off the drug resistance generation. Recently, photothermal therapy (PTT) has emerged as promising solution efficiently damage integrity pathogenic based on hyperthermia beyond their tolerance. Until now, numerous agents studied for antimicrobial PTT. Among them, MXenes (a type two-dimensional transition metal carbides or nitrides) are extensively investigated one most candidates due high aspect ratio, atomic-thin thickness, excellent performance, low cytotoxicity, ultrahigh dispersibility in aqueous systems. Besides, application scenarios using antibacterial properties can be tailored via elaborated designs MXenes-based materials. In this review, synthetic approaches textural systematically presented first, then mechanisms materials documented. Subsequently, recent progress diverse fields making use performances well summarized reveal potential applications various purposes, including vitro vivo sterilization, solar water evaporation purification, flexible fabrics. Last but not least, current challenges future perspectives discussed provide theoretical guidance fabrication systems MXenes.

Язык: Английский

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MXenes Antibacterial Properties and Applications: A Review and Perspective

Small, Год журнала: 2023, Номер 19(14)

Опубликована: Янв. 5, 2023

The mutations of bacteria due to the excessive use antibiotics, and generation antibiotic-resistant have made development new antibacterial compounds a necessity. MXenes emerged as biocompatible transition metal carbide structures with extensive biomedical applications. This is related MXenes' unique combination properties, including multifarious elemental compositions, 2D-layered structure, large surface area, abundant terminations, excellent photothermal photoelectronic properties. focus this review application MXenes, which has attracted attention researchers since 2016. A quick overview synthesis strategies provided then summarizes effect various factors (including structural optical charges, flake size, dispersibility) on biocidal activity MXenes. main mechanisms for deactivating by are discussed in detail rupturing bacterial membrane sharp edges nanoflakes, generating reactive oxygen species (ROS), bacteria. Hybridization other organic inorganic materials can result improved activities different applications such wound dressings water purification. Finally, challenges perspectives MXene nanomaterials agents presented.

Язык: Английский

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Biomedical Applications of MXene‐Integrated Composites: Regenerative Medicine, Infection Therapy, Cancer Treatment, and Biosensing

Advanced Functional Materials, Год журнала: 2022, Номер 32(34)

Опубликована: Июнь 24, 2022

Abstract MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical biological properties, gained much attention in the biomedical field recent years, including drug delivery systems, regenerative medicine, biosensing. Additionally, incorporation into hydrogels has garnered significant interest engineering an electroactive mechanical nanoreinforcer capable converting nonconductive scaffolds excellent conductors electricity with impressive effect on properties for organs tissues such cardiac, skeletal muscle, nerve. However, many questions problems remain unresolved that need be answered usher these materials toward true destiny. Thus, this review paper aims provide overview design applications MXene‐integrated composites applications, cardiac tissue engineering, wound healing, infection therapy, cancer biosensors. Moreover, current challenges limitations utilizing vivo are highlighted discussed, followed by its prospects guideline possible various futuristic applications. This article will inspire researchers, who search opportunities, using nanomaterial

Язык: Английский

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A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing

Advanced Science, Год журнала: 2022, Номер 9(14)

Опубликована: Март 10, 2022

Abstract Pathogenic bacteria infection is a serious threat to human public health due the high morbidity and mortality rates. Nano delivery system for delivering antibiotics provides an alternative option improve efficiency compared conventional therapeutic agents. In addition drug loading capacity of nanocarriers, which typically around 10%, further lowers dose that pathological are exposed to. Moreover, nanocarriers not eliminated from body may cause side effects. These limitations have motivated development self‐delivery systems formed by self‐assembly different this study, vehicle‐free antimicrobial polymer polyhexamethylene biguanide (PHMB, with bactericidal anti‐biofilm functions) hybrid gold nanoparticle (Au NPs, photothermal therapy (PTT)) platform (PHMB@Au NPs) developed. This exhibits excellent synergistic effect enhance Staphylococcus aureus under near‐infrared irradiation. Furthermore, results showed PHMB@Au NPs inhibit formation biofilms, quickly remove promote wound healing through PTT in model vivo, even mediate transition macrophages M1 M2 type, accelerate tissue angiogenesis. will promising value as highly effective agents patient management.

Язык: Английский

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Inorganic–organic hybrid nanomaterials for photothermal antibacterial therapy

Coordination Chemistry Reviews, Год журнала: 2023, Номер 496, С. 215426 - 215426

Опубликована: Сен. 6, 2023

Язык: Английский

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Biomedical engineering of two-dimensional MXenes

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 184, С. 114178 - 114178

Опубликована: Фев. 26, 2022

Язык: Английский

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Beyond Ti-based MXenes: A review of emerging non-Ti based metal-MXene structure, properties, and applications

Materials Today, Год журнала: 2023, Номер 63, С. 313 - 338

Опубликована: Фев. 18, 2023

Язык: Английский

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Recent advances in the photothermal applications of two-dimensional nanomaterials: photothermal therapy and beyond

Journal of Materials Chemistry A, Год журнала: 2021, Номер 9(33), С. 17569 - 17591

Опубликована: Янв. 1, 2021

The photothermal applications of 2D nanomaterials in therapy, water evaporation, thermochemical reactions, light-driven actuators, electrodes, energy storage, wearable heaters and bacterial inhibition.

Язык: Английский

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Infection Micromilieu‐Activated Nanocatalytic Membrane for Orchestrating Rapid Sterilization and Stalled Chronic Wound Regeneration

Advanced Functional Materials, Год журнала: 2021, Номер 32(7)

Опубликована: Ноя. 5, 2021

Abstract Pathogenic infection inevitably provokes chronic inflammation and stalls the normal orchestrated course of wound‐healing cascades. However, current antibacterial therapies focus on inherent bactericidal functions biomaterials. To take full advantage microenvironment (IME) peculiarities, an IME‐activated nanocatalytic membrane consisting electrospun poly (lactic‐co‐glycolic acid) (PLGA) scaffolds, MXene/Ag 2 S bio‐heterojunctions (MX/AS bio‐HJs), lactate oxidase (LOx) for cutaneous regeneration is devised developed. In this “intelligent” system, PLGA membranes gradually degrade to lactate, LOx consumes yield abundant hydrogen peroxide (H O ) in a microenvironment‐responsive manner. addition, MX/AS bio‐HJs not only exert benign photothermal effects generate reactive oxygen species upon NIR light, but also catalyze produced H overwhelming hydroxyl radicals (·OH) through Fenton‐like reactions, which all result rapid synergistic sterilization. Furthermore, vivo assays demonstrate that reshape stalled wound into regenerative by massacring bacteria, stopping bleeding, boosting epithelialization/collagen deposition beds, promoting angiogenesis. As envisaged, proposed tactic opens up promising opportunity arming with IME‐responsive activity remedy bacteria‐invaded full‐thickness wounds.

Язык: Английский

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