Advanced Healthcare Materials,
Год журнала:
2020,
Номер
9(12)
Опубликована: Май 7, 2020
Abstract
The
progressive
development
of
zeolitic
imidazolate
frameworks
(ZIFs),
as
a
subfamily
metal‐organic
(MOFs),
and
their
unique
features,
including
tunable
pore
size,
large
surface
area,
high
thermal
stability,
biodegradability/biocompatibility,
have
made
them
attractive
in
the
field
biomedicine,
especially
for
drug
delivery
biomineralization
applications.
porosity
ZIFs
gives
opportunity
encapsulating
amount
therapeutic
drugs,
proteins,
imaging
cargos,
or
combination
to
construct
advanced
multifunctional
systems
(DDSs)
with
combined
capabilities.
This
review
summarizes
recent
strategies
on
design
fabrication
ZIF‐based
nansystems
exploration
biomedical
field.
First,
developments
adjustment
particle
functionality,
morphology
are
discussed,
which
important
achieving
optimized
therapeutic/theranostic
nanosystems.
Second,
trends
application
ZIF
nanocarriers
loading
diverse
anticancer
medicines,
antibiotic
enzymes,
photosensitizers,
well
photothermal
agents,
investigated
order
understand
how
DDSs
can
be
designed
based
nanoparticles
treat
different
diseases,
such
cancer
infection.
Finally,
prospects
future
research
direction
applications
nanomedicines
discussed.
Regenerative Biomaterials,
Год журнала:
2022,
Номер
9
Опубликована: Янв. 1, 2022
Nowadays,
biomaterials
have
evolved
from
the
inert
supports
or
functional
substitutes
to
bioactive
materials
able
trigger
promote
regenerative
potential
of
tissues.
The
interdisciplinary
progress
has
broadened
definition
'biomaterials',
and
a
typical
new
insight
is
concept
tissue
induction
biomaterials.
term
'regenerative
biomaterials'
thus
contents
this
article
are
relevant
yet
beyond
This
review
summarizes
recent
medical
including
metals,
ceramics,
hydrogels,
other
polymers
bio-derived
materials.
As
application
aspects
concerned,
introduces
for
bone
cartilage
regeneration,
cardiovascular
repair,
3D
bioprinting,
wound
healing
cosmetology.
Cell-biomaterial
interactions
highlighted.
Since
global
pandemic
coronavirus
disease
2019,
particularly
mentions
public
health
emergency.
In
last
section,
perspectives
suggested:
(i)
creation
source
innovation;
(ii)
modification
existing
an
effective
strategy
performance
improvement;
(iii)
biomaterial
degradation
regeneration
required
be
harmonious
with
each
other;
(iv)
host
responses
can
significantly
influence
clinical
outcomes;
(v)
long-term
outcomes
should
paid
more
attention
to;
(vi)
noninvasive
approaches
monitoring
Acta Pharmaceutica Sinica B,
Год журнала:
2021,
Номер
11(10), С. 3060 - 3091
Опубликована: Май 7, 2021
Acute
respiratory
distress
syndrome
(ARDS)
is
characterized
by
the
severe
inflammation
and
destruction
of
lung
air-blood
barrier,
leading
to
irreversible
substantial
function
damage.
Patients
with
coronavirus
disease
2019
(COVID-19)
have
been
encountered
a
high
risk
ARDS,
underscoring
urgency
for
exploiting
effective
therapy.
However,
proper
medications
ARDS
are
still
lacking
due
poor
pharmacokinetics,
non-specific
side
effects,
inability
surmount
pulmonary
inadequate
management
heterogeneity.
The
increased
permeability
in
pathological
environment
may
contribute
nanoparticle-mediated
passive
targeting
delivery.
Nanomedicine
has
demonstrated
unique
advantages
solving
dilemma
drug
therapy,
which
can
address
shortcomings
limitations
traditional
anti-inflammatory
or
antioxidant
treatment.
Through
passive,
active,
physicochemical
targeting,
nanocarriers
interact
epithelium/endothelium
inflammatory
cells
reverse
abnormal
changes
restore
homeostasis
environment,
thereby
showing
good
therapeutic
activity
reduced
toxicity.
This
article
reviews
latest
applications
nanomedicine
pre-clinical
highlights
strategies
targeted
treatment
inflammation,
presents
innovative
delivery
systems,
provides
inspiration
strengthening
effect
nanomedicine-based
Acta Pharmaceutica Sinica B,
Год журнала:
2021,
Номер
11(5), С. 1158 - 1174
Опубликована: Март 12, 2021
Increasing
understanding
of
the
pathogenesis
rheumatoid
arthritis
(RA)
has
remarkably
promoted
development
effective
therapeutic
regimens
RA.
Nevertheless,
inadequate
response
to
current
therapies
in
a
proportion
patients,
systemic
toxicity
accompanied
by
long-term
administration
or
distribution
non-targeted
sites
and
comprised
efficacy
caused
undesirable
bioavailability,
are
still
unsettled
problems
lying
across
full
remission
So
far,
these
existing
limitations
have
inspired
comprehensive
academic
researches
on
nanomedicines
for
RA
treatment.
A
variety
versatile
nanocarriers
with
controllable
physicochemical
properties,
tailorable
drug
release
pattern
active
targeting
ability
were
fabricated
enhance
delivery
efficiency
This
review
aims
provide
an
up-to-date
progress
regarding
treatment
using
last
5
years
concisely
discuss
potential
application
several
newly
emerged
strategies
such
as
inducing
antigen-specific
tolerance,
pro-resolving
therapy
regulating
immunometabolism
treatments.
Abstract
The
tumor
microenvironment
(TME),
including
intracellular
and
extracellular
microenvironment,
contains
many
biochemical
indicators
(such
as
acidity/alkalinity,
oxygen
content,
enzymatic
activity)
that
are
different
from
the
normal
physiological
environment.
These
abnormal
can
accelerate
heterogeneity
of
tumors,
but
on
other
hand,
they
also
provide
opportunities
for
design
intelligent
drug
delivery
systems
(DDSs).
TME‐responsive
DDSs
have
shown
great
potential
in
reducing
side
effects
chemotherapy
improving
curative
effect
tumors.
In
this
review,
TME
introduced
detail
both
aspects.
view
various
barriers
encountered
during
delivery,
strategy
constructing
is
discussed.
By
summarizing
typical
research
progress,
authors
prospect
development
DDS
future.
Biomaterials Science,
Год журнала:
2022,
Номер
10(5), С. 1193 - 1208
Опубликована: Янв. 1, 2022
Macrophage
membrane
coated
nanomaterials
are
used
in
various
therapies,
against
infections
and
inflammation
order
to
combat
immune
barriers
without
compromising
the
efficacy
of
“cargo”
molecules.
Bioengineering & Translational Medicine,
Год журнала:
2022,
Номер
8(2)
Опубликована: Ноя. 2, 2022
Abstract
Poly(lactic‐
co
‐glycolic
acid)
(PLGA)
nanoparticles
(NPs)
are
commonly
used
for
drug
delivery
because
of
their
favored
biocompatibility
and
suitability
sustained
controlled
release.
To
prolong
NP
circulation
time,
enable
target‐specific
overcome
physiological
barriers,
NPs
camouflaged
in
cell
membranes
have
been
developed
evaluated
to
improve
delivery.
Here,
we
discuss
recent
advances
membrane‐coated
PLGA
NPs,
preparation
methods,
application
cancer
therapy,
management
inflammation,
treatment
cardiovascular
disease
control
infection.
We
address
the
current
challenges
highlight
future
research
directions
needed
effective
use
membrane‐camouflaged
NPs.
Advanced Materials,
Год журнала:
2022,
Номер
34(30)
Опубликована: Июнь 7, 2022
Osteoarthritis
(OA)
is
a
low-grade
inflammatory
and
progressive
joint
disease,
its
progression
closely
associated
with
an
imbalance
in
M1/M2
synovial
macrophages.
Repolarizing
pro-inflammatory
M1
macrophages
into
the
anti-inflammatory
M2
phenotype
emerging
as
strategy
to
alleviate
OA
but
compromised
by
unsatisfactory
efficiency.
In
this
study,
reprogramming
of
mitochondrial
dysfunction
pioneered
camouflaged
meta-Defensome,
which
can
transform
high
efficiency
82.3%.
The
meta-Defensome
recognizes
activated
via
receptor-ligand
interactions
accumulates
mitochondria
through
electrostatic
attractions.
These
meta-Defensomes
are
macrophage-membrane-coated
polymeric
nanoparticles
decorated
dual
ligands
co-loaded
S-methylisothiourea
MnO2
.
Meta-Defensomes
demonstrated
successfully
reprogram
metabolism
scavenging
reactive
oxygen
species
inhibiting
NO
synthase,
thereby
increasing
transcription
factor
A
expression
restoring
aerobic
respiration.
Furthermore,
intravenously
injected
collagenase-induced
osteoarthritis
mice
effectively
suppress
inflammation
early
OA,
evident
from
Research
Society
International
score.
Therefore,
serve
novel
practical
approach
repolarize
promising
therapeutic
agent
for
impeding
tclinic.
