Biomaterials, Journal Year: 2020, Volume and Issue: 255, P. 120197 - 120197
Published: June 12, 2020
Language: Английский
Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 9(12)
Published: May 7, 2020
Abstract The progressive development of zeolitic imidazolate frameworks (ZIFs), as a subfamily metal‐organic (MOFs), and their unique features, including tunable pore size, large surface area, high thermal stability, biodegradability/biocompatibility, have made them attractive in the field biomedicine, especially for drug delivery biomineralization applications. porosity ZIFs gives opportunity encapsulating amount therapeutic drugs, proteins, imaging cargos, or combination to construct advanced multifunctional systems (DDSs) with combined capabilities. This review summarizes recent strategies on design fabrication ZIF‐based nansystems exploration biomedical field. First, developments adjustment particle functionality, morphology are discussed, which important achieving optimized therapeutic/theranostic nanosystems. Second, trends application ZIF nanocarriers loading diverse anticancer medicines, antibiotic enzymes, photosensitizers, well photothermal agents, investigated order understand how DDSs can be designed based nanoparticles treat different diseases, such cancer infection. Finally, prospects future research direction applications nanomedicines discussed.
Language: Английский
Citations
150
Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 9
Published: Jan. 1, 2022
Nowadays, biomaterials have evolved from the inert supports or functional substitutes to bioactive materials able trigger promote regenerative potential of tissues. The interdisciplinary progress has broadened definition 'biomaterials', and a typical new insight is concept tissue induction biomaterials. term 'regenerative biomaterials' thus contents this article are relevant yet beyond This review summarizes recent medical including metals, ceramics, hydrogels, other polymers bio-derived materials. As application aspects concerned, introduces for bone cartilage regeneration, cardiovascular repair, 3D bioprinting, wound healing cosmetology. Cell-biomaterial interactions highlighted. Since global pandemic coronavirus disease 2019, particularly mentions public health emergency. In last section, perspectives suggested: (i) creation source innovation; (ii) modification existing an effective strategy performance improvement; (iii) biomaterial degradation regeneration required be harmonious with each other; (iv) host responses can significantly influence clinical outcomes; (v) long-term outcomes should paid more attention to; (vi) noninvasive approaches monitoring
Language: Английский
Citations
143
Small Methods, Journal Year: 2022, Volume and Issue: 6(8)
Published: June 29, 2022
Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.
Language: Английский
Citations
139
Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(10), P. 3060 - 3091
Published: May 7, 2021
Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation and destruction of lung air-blood barrier, leading to irreversible substantial function damage. Patients with coronavirus disease 2019 (COVID-19) have been encountered a high risk ARDS, underscoring urgency for exploiting effective therapy. However, proper medications ARDS are still lacking due poor pharmacokinetics, non-specific side effects, inability surmount pulmonary inadequate management heterogeneity. The increased permeability in pathological environment may contribute nanoparticle-mediated passive targeting delivery. Nanomedicine has demonstrated unique advantages solving dilemma drug therapy, which can address shortcomings limitations traditional anti-inflammatory or antioxidant treatment. Through passive, active, physicochemical targeting, nanocarriers interact epithelium/endothelium inflammatory cells reverse abnormal changes restore homeostasis environment, thereby showing good therapeutic activity reduced toxicity. This article reviews latest applications nanomedicine pre-clinical highlights strategies targeted treatment inflammation, presents innovative delivery systems, provides inspiration strengthening effect nanomedicine-based
Language: Английский
Citations
129
Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(5), P. 1158 - 1174
Published: March 12, 2021
Increasing understanding of the pathogenesis rheumatoid arthritis (RA) has remarkably promoted development effective therapeutic regimens RA. Nevertheless, inadequate response to current therapies in a proportion patients, systemic toxicity accompanied by long-term administration or distribution non-targeted sites and comprised efficacy caused undesirable bioavailability, are still unsettled problems lying across full remission So far, these existing limitations have inspired comprehensive academic researches on nanomedicines for RA treatment. A variety versatile nanocarriers with controllable physicochemical properties, tailorable drug release pattern active targeting ability were fabricated enhance delivery efficiency This review aims provide an up-to-date progress regarding treatment using last 5 years concisely discuss potential application several newly emerged strategies such as inducing antigen-specific tolerance, pro-resolving therapy regulating immunometabolism treatments.
Language: Английский
Citations
104
Small Methods, Journal Year: 2022, Volume and Issue: 6(3)
Published: Jan. 20, 2022
Abstract The tumor microenvironment (TME), including intracellular and extracellular microenvironment, contains many biochemical indicators (such as acidity/alkalinity, oxygen content, enzymatic activity) that are different from the normal physiological environment. These abnormal can accelerate heterogeneity of tumors, but on other hand, they also provide opportunities for design intelligent drug delivery systems (DDSs). TME‐responsive DDSs have shown great potential in reducing side effects chemotherapy improving curative effect tumors. In this review, TME introduced detail both aspects. view various barriers encountered during delivery, strategy constructing is discussed. By summarizing typical research progress, authors prospect development DDS future.
Language: Английский
Citations
98
Biomaterials Science, Journal Year: 2022, Volume and Issue: 10(5), P. 1193 - 1208
Published: Jan. 1, 2022
Macrophage membrane coated nanomaterials are used in various therapies, against infections and inflammation order to combat immune barriers without compromising the efficacy of “cargo” molecules.
Language: Английский
Citations
96
Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(2)
Published: Nov. 2, 2022
Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability sustained controlled release. To prolong NP circulation time, enable target‐specific overcome physiological barriers, NPs camouflaged in cell membranes have been developed evaluated to improve delivery. Here, we discuss recent advances membrane‐coated PLGA NPs, preparation methods, application cancer therapy, management inflammation, treatment cardiovascular disease control infection. We address the current challenges highlight future research directions needed effective use membrane‐camouflaged NPs.
Language: Английский
Citations
84
Advanced Materials, Journal Year: 2022, Volume and Issue: 34(30)
Published: June 7, 2022
Osteoarthritis (OA) is a low-grade inflammatory and progressive joint disease, its progression closely associated with an imbalance in M1/M2 synovial macrophages. Repolarizing pro-inflammatory M1 macrophages into the anti-inflammatory M2 phenotype emerging as strategy to alleviate OA but compromised by unsatisfactory efficiency. In this study, reprogramming of mitochondrial dysfunction pioneered camouflaged meta-Defensome, which can transform high efficiency 82.3%. The meta-Defensome recognizes activated via receptor-ligand interactions accumulates mitochondria through electrostatic attractions. These meta-Defensomes are macrophage-membrane-coated polymeric nanoparticles decorated dual ligands co-loaded S-methylisothiourea MnO2 . Meta-Defensomes demonstrated successfully reprogram metabolism scavenging reactive oxygen species inhibiting NO synthase, thereby increasing transcription factor A expression restoring aerobic respiration. Furthermore, intravenously injected collagenase-induced osteoarthritis mice effectively suppress inflammation early OA, evident from Research Society International score. Therefore, serve novel practical approach repolarize promising therapeutic agent for impeding tclinic.
Language: Английский
Citations
82
Advanced Materials, Journal Year: 2022, Volume and Issue: 34(12)
Published: Jan. 19, 2022
Overactivated T cells and overproduced pro-inflammatory cytokines form a self-amplified signaling loop to continuously exacerbate the dysregulated inflammatory response propel progression of autoimmune diseases (AIDs). Herein, immuno-engineered nanodecoys (NDs) based on poly(lactic-co-glycolic acid) nanoparticles coated with programmed death-ligand 1 (PD-L1)-expressing macrophage membrane (PRM) are developed mediate multi-target interruption self-promoted cascade in AIDs. The PRM collected from IFN-γ-treated RAW 264.7 possesses elevated surface levels adhesion molecule receptors cytokine receptors, and, thus, systemically administered NDs afford higher accumulation level inflamed tissues stronger scavenging efficiency toward multiple cytokines. More importantly, IFN-γ treatment induces remarkable PD-L1 expression PRM, thereby allowing bind membrane-bound death-1 (PD-1) CD4+ cell surfaces or neutralize free soluble PD-1, which reconstructs PD-1/PD-L1 inhibitory axis suppress activation restore immune tolerance. As such, provoke potent cooperative anti-inflammatory immune-suppressive efficacies alleviate damages Zymosan A-induced arthritis mice dextran sulfate sodium-induced ulcerative colitis mice. This study provides an enlightened example for immuno-engineering cell-membrane-based NDs, rendering promising implications into AIDs via immune-modulation.
Language: Английский
Citations
75