Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(35), С. 14789 - 14804

Опубликована: Авг. 7, 2020

Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital capacity in the conventional wavelength range (400–950 nm) been restricted by extremely limited tissue penetration. To tackle this challenge, novel approach using fluorescence second near-infrared window (NIR-II, 1000–1700 developed past decade to achieve deep penetration and high-fidelity imaging, thus significant applications have begun emerge. In Perspective, we first examine recent discoveries challenges development of NIR-II fluorophores compatible apparatuses. Subsequently, advances bioimaging, biosensing, therapy such cutting-edge technique are highlighted. Finally, based on achievement representative studies, elucidate main concerns regarding give some advice prospects future applications.

Язык: Английский

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Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications

Advanced Functional Materials, Год журнала: 2020, Номер 31(8)

Опубликована: Ноя. 18, 2020

Abstract The complex tissue‐specific physiology that is orchestrated from the nano‐ to macroscale, in conjugation with dynamic biophysical/biochemical stimuli underlying biological processes, has inspired design of sophisticated hydrogels and nanoparticle systems exhibiting stimuli‐responsive features. Recently, nanoparticles have been combined advanced nanocomposite hybrid platforms expanding their range biomedical applications. ease flexibility attaining modular hydrogel constructs by selecting different classes nanomaterials/hydrogels, or tuning nanoparticle‐hydrogel physicochemical interactions widely expands attainable properties levels beyond those traditional platforms. This review showcases intrinsic ability react external internal/physiological scope developing intelligent application‐oriented Moreover, are overviewed context encoding cascades recapitulate signaling interplays present native biosystems. Collectively, recent breakthroughs improve potential for operating as applications benefit tailored single multi‐responsiveness.

Язык: Английский

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Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

Materials Today Bio, Год журнала: 2021, Номер 13, С. 100186 - 100186

Опубликована: Дек. 9, 2021

Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left door open for further improvement their applications to revitalize impaired tissues. Hence, restoring functions. The implementation therapeutic protocols merge biomimetic scaffolds, bioactive molecules, cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended engineering other biomedical purposes. They can simulate physicochemical, mechanical, biological characters innate Also, they provide aqueous conditions cell growth, support 3D conformation, mechanical stability cells, serve potent delivery matrices molecules. Many natural artificial polymers were broadly utilized design these intelligent platforms with novel advanced characteristics tailored functionalities fit such applications. In present review, we highlighted different types smart/stimuli-responsive emphasis on synthesis scheme. Besides, mechanisms responsiveness stimuli elaborated. Their potential was discussed. Furthermore, exploitation targeted drug delivery, smart biosensors, actuators, 4D printing, culture outlined. addition, threw light self-healing biomedicine. Eventually, presented future perceptions Conclusively, current progress enhances prospective function intelligent, sophisticated systems

Язык: Английский

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Light: A Magical Tool for Controlled Drug Delivery

Advanced Functional Materials, Год журнала: 2020, Номер 30(49)

Опубликована: Сен. 9, 2020

Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application and exquisite temporal spatial control. Great progress has been achieved in the development novel light-driven strategies with both breadth depth. Light-controlled platforms can be generally categorized into three groups: photochemical, photothermal, photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, sulfides oxides, metal-organic frameworks, carbon nanomaterials, upconversion semiconductor stimuli-responsive micelles, polymer- liposome-based nanoparticles have applied light-stimulated delivery. In view increasing interest targeted delivery, we review light-responsive systems focus on recent advances, key limitations, future directions.

Язык: Английский

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Materials with Tunable Optical Properties for Wearable Epidermal Sensing in Health Monitoring

Advanced Materials, Год журнала: 2022, Номер 34(26)

Опубликована: Март 8, 2022

Advances in wearable epidermal sensors have revolutionized the way that physiological signals are captured and measured for health monitoring. One major challenge is to convert easily readable a convenient way. possibility based on visible readouts. There range of materials whose optical properties can be tuned by parameters such as temperature, pH, light, electric fields. Herein, this review covers highlights set with tunable their integration into Specifically, recent progress, fabrication, applications these summarized discussed. Finally, challenges perspectives next generation devices proposed.

Язык: Английский

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Recent advances in the development of near-infrared organic photothermal agents

Chemical Engineering Journal, Год журнала: 2021, Номер 417, С. 128844 - 128844

Опубликована: Фев. 7, 2021

Язык: Английский

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Large π-Conjugated Metal–Organic Frameworks for Infrared-Light-Driven CO₂ Reduction

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(3), С. 1218 - 1231

Опубликована: Янв. 14, 2022

It remains challenging to excite traditional photocatalysts through near-infrared (NIR) light. Attempts use NIR-light-response materials for photochemical reduction usually suffer from inapposite band position due extremely narrow gaps. Here, we report that large π-conjugated organic semiconductor engineered metal-organic framework (MOF) can result in NIR-light-driven CO2 catalyst with high photocatalytic activity. A series of mesoporous MOFs, progressively increased macrocyclic units, were synthesized tuning the light adsorption range and catalytic performance. Attainment these MOFs single-crystal form revealed identical topology precise spatial arrangements constituent units metal clusters. Furthermore, ultrafast spectroscopic studies confirmed formation charge separation state mechanism underlying photoexcited dynamics. This combined X-ray photoelectron spectroscopy situ electron paramagnetic resonance verified photoinduced transfer pathway within reduction. Specifically, tetrakis(4-carboxybiphenyl)naphthoporphyrin) MOF (TNP-MOF) photocatalyst displayed an unprecedentedly rate over 6630 μmol h-1 g-1 under NIR irradiation, apparent quantum efficiencies (AQE) at 760 808 nm 2.03% 1.11%, respectively. The performance outperformed all other MOF-based photocatalysts, even visible-light-driven catalysts.

Язык: Английский

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Friends against the Foe: Synergistic Photothermal and Photodynamic Therapy against Bacterial Infections

Pharmaceutics, Год журнала: 2023, Номер 15(4), С. 1116 - 1116

Опубликована: Март 31, 2023

Multidrug-resistant (MDR) bacteria are rapidly emerging, coupled with the failure of current antibiotic therapy; thus, new alternatives for effectively treating infections caused by MDR required. Hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic (PDT) have attracted extensive attention as antibacterial therapies owing to advantages such low invasiveness, toxicity, likelihood causing bacterial resistance. However, both strategies notable drawbacks, including high temperature requirements PTT weak ability PDT-derived ROS penetrate target cells. To overcome these limitations, a combination PDT has been used against bacteria. In this review, we discuss unique benefits limitations The mechanisms underlying synergistic effects PTT–PDT also discussed. Furthermore, introduced advancements in methods using nano-based agents treat Finally, highlight existing challenges future perspectives We believe that review will encourage PTT- PDT-based research can be referenced clinical applications.

Язык: Английский

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Pore-engineered nanoarchitectonics for cancer therapy

NPG Asia Materials, Год журнала: 2023, Номер 15(1)

Опубликована: Март 31, 2023

Abstract Nanoarchitectonics describes the integration of nanotechnology with other fields as a postnanotechnology concept that elevates it to material science. Based on this fundamental principle, we address pore-engineered nanoarchitectonics application targets for cancer therapy by combining basic descriptions and exemplifying applications in review. The initial two sections briefly summarize basics according classification based (i) porosity (ii) composition. Afterward, main application-oriented section—designing mesoporous therapy—is presented. Various types drug delivery systems, including nanoparticles nanocarriers, endogenous stimuli-responsive delivery, exogenous targeted are described. Importantly, clinical translation materials is further discussed. Mesoporous unique offer network cavities vehicles nanocarriers. Regarding developments allow be broadly used settings, there several challenges should solved their application. From perspective, tremendous processes development materials.

Язык: Английский

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Lanthanide-based nanoparticles for cancer phototherapy

Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215773 - 215773

Опубликована: Март 14, 2024

Phototherapy, using light as a therapeutic modality, has been widely applied in treating various diseases, especially cancer. This approach is valued for its non-invasive nature and minimal risk of drug resistance. However, phototherapy faces challenges such the undesired delivery phototherapeutic agents, potential phototoxicity, limited penetration into tissues. Lanthanide-doped nanoparticles offer attractive opportunities to improve efficacy photodynamic therapy. These are distinguished by their unique optical properties, excellent photostability against blinking bleaching effects, large Stokes or anti-Stokes shifts, sharp emission peaks, long luminescence lifetimes. In addition, lanthanide-doped can be excited near-infrared (NIR) X-rays, enabling deep-tissue penetration. Beyond use photosensitizers, nanoparticle surfaces easily modified with targeting ligands, chemical drugs, functional molecules enhance effectiveness enable combination this review, we organize lanthanide-based tumor six main domains: therapy, photothermal X-ray-based light-controlled photoimmunotherapy, other innovative treatments that regulated light. We introduce basic principles characteristics lanthanide nanoparticles. Following this, summarize latest advances utilizing phototherapy, focusing on design principles, mechanisms action, cancer treatment. To conclude, address existing explore future within area research.

Язык: Английский

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