Advanced Functional Materials,
Год журнала:
2024,
Номер
34(28)
Опубликована: Фев. 7, 2024
Abstract
The
integration
of
real‐time
monitoring
and
on‐demand
treatment
has
substantial
potential
to
accelerate
wound
healing
processes.
In
this
context,
versatile
bilayer
microneedles
(MNs)
a
triboelectric
nanogenerator
(TENG)
are
developed
as
theranostic
platform
for
efficient
management.
This
provides
benefits
including
controlling
infection,
promoting
cell
migration
proliferation,
the
capability
biochemical
sensing.
MNs
comprise
solvable
polyvinylpyrrolidone
MN
(pMN)
affixed
atop
conductive
stainless‐steel
(sMN).
robust
sMN
penetrates
requisite
skin
depth,
while
pMN,
infused
with
antibiotics,
ensures
sustained
drug
release
upon
dissolution
in
interstitial
fluids.
Concurrently,
TENG
generates
electrical
stimulation
transmitted
site
through
sMN,
contributing
accelerated
closure.
Furthermore,
coated
silver
carbon
nanotubes
(CNT/Ag/sMN),
functions
transdermal
electrochemical
sensor
assess
state
by
detecting
hydrogen
peroxide
uric
acid.
Notably,
vivo
animal
studies
have
demonstrated
that
MN‐TENG
device
not
only
effectively
inhibits
bacterial
growth
expedites
but
also
monitors
biomarkers,
thereby
validating
its
utility
improving
infected
recovery.
Consequently,
based
strategy
fosters
advancements
diagnostic
therapeutic
technologies
within
management
related
biomedical
domains.
Communications Materials,
Год журнала:
2024,
Номер
5(1)
Опубликована: Март 13, 2024
Abstract
Interstitial
fluid
(ISF),
a
biological
rich
in
diverse
biomarkers
and
analytes
similar
to
blood
composition,
has
garnered
significant
attention
as
valuable
source
of
clinically
relevant
information.
Consequently,
ISF-based
wearable
biosensors
are
emerging
powerful
tools
for
non-invasive
minimally
invasive
disease
diagnosis,
personalized
medicine,
other
healthcare
biomedical
applications.
This
review
provides
comprehensive
overview
recent
advancements
biosensors,
with
particular
focus
on
ISF
sensors.
We
first
offer
insights
into
sampling
techniques
discuss
sensing
strategies
that
encompass
materials,
fabrication
methods,
mechanisms.
Then,
we
present
their
Finally,
address
the
challenges
faced
this
field
forward-looking
perspective
promising
future
directions.
ACS Nano,
Год журнала:
2024,
Номер
18(3), С. 2335 - 2345
Опубликована: Янв. 8, 2024
Stretchable
sweat
sensors
have
become
a
personalized
wearable
platform
for
continuous,
noninvasive
health
monitoring
through
conformal
integration
with
the
human
body.
Typically,
these
devices
are
coupled
soft
microfluidic
systems
to
control
flow
during
advanced
analysis
processes.
However,
implementation
of
is
limited
by
their
high
fabrication
costs
and
need
skin
adhesives
block
natural
perspiration.
To
overcome
limitations,
stretchable
smart
wettable
patch
has
been
proposed
multiplexed
in
situ
perspiration
analysis.
The
includes
porous
membrane
form
patterned
microfoam
nanofiber
layer
laminate,
which
extracts
selectively
from
directs
its
continuous
across
device.
integrated
electrochemical
sensor
array
measures
multiple
biomarkers
simultaneously
such
as
pH,
K+,
Na+.
sensing
comprises
compliant
materials
structures
that
allow
deformability
up
50%
strain,
enables
stable
seamless
interface
curvilinear
During
physical
exercise,
device
demonstrated
special
operating
mode
actively
accumulating
multiplex
biomarker
profiles.
provides
an
affordable
solution
address
sampling
challenges
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(17), С. 8632 - 8712
Опубликована: Янв. 1, 2024
Bioelectronics
is
a
hot
research
topic,
yet
an
important
tool,
as
it
facilitates
the
creation
of
advanced
medical
devices
that
interact
with
biological
systems
to
effectively
diagnose,
monitor
and
treat
broad
spectrum
health
conditions.
Electrical
stimulation
(ES)
pivotal
technique
in
bioelectronics,
offering
precise,
non-pharmacological
means
modulate
control
processes
across
molecular,
cellular,
tissue,
organ
levels.
This
method
holds
potential
restore
or
enhance
physiological
functions
compromised
by
diseases
injuries
integrating
sophisticated
electrical
signals,
device
interfaces,
designs
tailored
specific
mechanisms.
review
explains
mechanisms
which
ES
influences
cellular
behaviors,
introduces
essential
principles,
discusses
performance
requirements
for
optimal
systems,
highlights
representative
applications.
From
this
review,
we
can
realize
based
bioelectronics
therapy,
regenerative
medicine
rehabilitation
engineering
technologies,
ranging
from
tissue
neurological
modulation
cardiovascular
cognitive
functions.
underscores
versatility
various
biomedical
contexts
emphasizes
need
adapt
complex
clinical
landscapes
addresses.
