Comparison of Different Intermittent Fasting Patterns or Different Extents of Calorie Restriction for Weight Loss and Metabolic Improvement in Adults: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials DOI
Xianglin Wu, Yi Ding, Qiuyu Cao

et al.

Nutrition Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract Context Continuous energy restriction (CER) and intermittent fasting (IF) are both prevalent diet regimens recommended for weight loss metabolic improvement. Objective The objective of this study was to evaluate the efficacy CER IF on improvement in adults with overweight, obesity, or abnormalities. Data Sources PubMed, Embase, Cochrane Library (CENTRAL) were searched randomized controlled trials 3 degrees 4 categories regimens, from inception databases December 2022. Extraction Two reviewers independently extracted demographic information, intervention duration, details dietary interventions, data outcomes interest. Analysis Bayesian random-effect network meta-analyses used pool results Grading Recommendations, Assessment, Development, Evaluation framework assess certainty evidence present findings. Results included 167 eligible a total enrollment 11 998 participants. Most induced significant that comparable by similar absolute restriction, based low- high-certainty evidence. Severe proved be most effective regimen obtaining loss, moderate-certainty (mean difference change 11.50 kg [95% CI 10.07 12.93]), followed alternate-day fasting, (5.07 3.44 6.72]) moderate CER, (6.09 5.26 6.93]), when being compared consistent their extent. Similar noticed body measurements, blood pressure, lipids, glycemic profiles. In subgroup analysis, weight-loss effects but not experienced rebound after 12 weeks. Conclusion abnormalities, effectiveness mainly depends extent regardless mealtime patterns. Systematic Review Registration PROSPERO registration no. CRD42022379621.

Language: Английский

Fasting: From Physiology to Pathology DOI Creative Commons
Dongmei Tang,

Qiuyan Tang,

Wei Huang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(9)

Published: Feb. 3, 2023

Overnutrition is a risk factor for various human diseases, including neurodegenerative metabolic disorders, and cancers. Therefore, targeting overnutrition represents simple but attractive strategy the treatment of these increasing public health threats. Fasting as dietary intervention combating has been extensively studied. practiced millennia, only recently have its roles in molecular clock, gut microbiome, tissue homeostasis function emerged. can slow aging most species protect against These centuried unfading adventures explorations suggest that fasting potential to delay help prevent treat diseases while minimizing side effects caused by chronic interventions. In this review, recent animal studies concerning role underlying mechanism physiology pathology are summarized, therapeutic highlighted, combination pharmacological discussed new regimen diseases.

Language: Английский

Citations

44
Reflection on Ramadan Fasting Research Related to Sustainable Development Goal 3 (Good Health and Well-Being): A Bibliometric Analysis DOI

Katia H. AbuShihab,

Khaled Obaideen, Mohamad Alameddine

et al.

Journal of Religion and Health, Journal Year: 2023, Volume and Issue: 63(5), P. 3329 - 3359

Published: Dec. 18, 2023

Language: Английский

Citations

30
Molecular Mechanisms of Healthy Aging: The Role of Caloric Restriction, Intermittent Fasting, Mediterranean Diet, and Ketogenic Diet—A Scoping Review DOI Open Access
Roxana Surugiu, Mihaela Adela Iancu, Ștefănița Bianca Vintilescu

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2878 - 2878

Published: Aug. 28, 2024

As the population ages, promoting healthy aging through targeted interventions becomes increasingly crucial. Growing evidence suggests that dietary can significantly impact this process by modulating fundamental molecular pathways. This review focuses on potential of strategies in and mechanisms which specific nutrients patterns influence key pathways involved cellular repair, inflammation, metabolic regulation. Caloric restriction, intermittent fasting, Mediterranean diet, as well ketogenic diet showed promising effects aging, possibly mTORC1 AMPK, an insulin signaling pathway. By understanding intricate interplay between pathways, we develop personalized not only prevent age-related diseases, but also promote overall health well-being throughout process.

Language: Английский

Citations

11
Alternate‐day fasting enhanced weight loss and metabolic benefits over pair‐fed calorie restriction in obese mice DOI Open Access

Hadia Nawaz,

Haneul Lee, Sumin Kang

et al.

Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract Objective Both alternate‐day fasting (ADF) and calorie restriction (CR) are effective weight loss strategies. However, most individuals find it difficult to adhere CR. Furthermore, CR can induce an excessive of not only fat but also muscle mass. This study aimed compare the effects ADF pair‐feeding (PF) on metabolic pathways underlying obesity in mice with high‐fat diet (HFD)‐induced obesity. Methods Male C57BL/6N Tac ( n = 10 per group) were fed HFD for 8 weeks establish a diet‐induced model. Mice then continued either access food or PF next weeks. We measured body weight, adiposity, plasma biomarkers, molecular mechanisms involving lipolysis autophagy. Results resulted comparable loss. Compared PF, showed significant reduction liver hepatic triglyceride levels. significantly increased ketone levels white adipose tissue lipolysis. tended activate autophagy elongation autophagosome formation, which insignificant. Conclusions These findings indicated that is promising intervention diseases, potentially due its superior efficacy promoting ketogenesis compared PF.

Language: Английский

Citations

2
The effects of intermittent fasting for patients with multiple sclerosis (MS): a systematic review DOI Creative Commons
Xiaoxiao Lin, Shuai Wang, Yue Gao

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 17, 2024

Some studies have investigated the impact of intermittent fasting (IF) for patients with multiple sclerosis (MS). We aimed to conduct a comprehensive systematic review analyze and summarize all clinical concerning effects IF on MS. conducted an exhaustive information available in Embase, Cochrane, PubMed databases up until 1 September 2023. All research relating impacts MS were included. In total, this encompassed 5 studies, which included four RCTs one pilot study. Each study involved was assessed high quality. The results from these demonstrate that protocols could potentially serve as effective dietary strategy managing symptoms improving quality life individuals afflicted conclusion, might be potential beneficial intervention However, number trials field is relatively limited. large-scale investigate are urgently needed, may helpful manage intricate neuroimmune disorder. Systematic registration https://inplasy.com , identifier INPLASY2023100021.

Language: Английский

Citations

9
Effects of healthy low-carbohydrate diet and time-restricted eating on weight and gut microbiome in adults with overweight or obesity: Feeding RCT DOI Creative Commons
Lin Li, Yulin Deng,

Qingying Tian

et al.

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(11), P. 101801 - 101801

Published: Oct. 24, 2024

Language: Английский

Citations

7
Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity? DOI Creative Commons

Maria Eugenia Parrotta,

Luca Colangeli,

Valeria SCIPIONE

et al.

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 3, 2025

Language: Английский

Citations

1
A Hierarchical Mechanotransduction System: From Macro to Micro DOI Creative Commons
Rong Cao,

Huimin Tian,

Yan Tian

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(11)

Published: Dec. 25, 2023

Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including forces and properties, are sensed translated into biochemical signals. Increasing data demonstrate that mechanotransduction crucial for regulating macroscopic microscopic dynamics functionalities. However, the actions mechanisms of across multiple hierarchies, from molecules, subcellular structures, cells, tissues/organs, to whole-body level, have not been yet comprehensively documented. Herein, biological roles operational macro micro revisited, with focus on orchestrations diverse hierarchies. The implications, applications, challenges in human diseases also summarized discussed. Together, this knowledge hierarchical perspective has potential refresh insights regulation disease pathogenesis therapy, ultimately revolutionize prevention, diagnosis, treatment diseases.

Language: Английский

Citations

14
Circular RNAs in hepatocellular carcinoma: biogenesis, function, and pathology DOI Creative Commons
Guocheng Rao, Peng Xi,

Yan Tian

et al.

Frontiers in Genetics, Journal Year: 2023, Volume and Issue: 14

Published: July 7, 2023

Hepatocellular carcinoma (HCC) is one of the most common causes cancer-related death worldwide. Both genetic and environmental factors through a multitude underlying molecular mechanisms participate in pathogenesis HCC. Recently, numerous studies have shown that circular RNAs (circRNAs), an emerging class non-coding characterized by presence covalent bonds linking 3' 5' ends, play important role initiation progression cancers, including In this review, we outline current status field circRNAs, with emphasis on functions circRNAs HCC its microenvironment. We also summarize discuss recent advances as biomarkers therapeutic targets. These efforts are anticipated to throw new insights into future perspectives about basic, translational clinical research, eventually advancing diagnosis, prevention treatment

Language: Английский

Citations

9
Decanoylcarnitine Inhibits Triple-Negative Breast Cancer Progression via Mmp9 in an Intermittent Fasting Obesity Mouse DOI Creative Commons
Yifan Tang, Daiwen Chen,

Saijun Wang

et al.

Technology in Cancer Research & Treatment, Journal Year: 2024, Volume and Issue: 23

Published: Jan. 1, 2024

Treatment of triple-negative breast cancer (TNBC) remains challenging. Intermittent fasting (IF) has emerged as a promising approach to improve metabolic health various disorders. Clinical studies indicate IF is essential for TNBC progression. However, the molecular mechanisms underlying remodeling in regulating and progression are still unclear.

Language: Английский

Citations

3