Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100597 - 100597
Опубликована: Фев. 26, 2023
Osteoarthritis
(OA)
and
rheumatoid
arthritis
(RA)
are
chronic
progressive
inflammatory
joint
diseases
that
affect
a
large
population
worldwide.
Intra-articular
administration
of
various
therapeutics
is
applied
to
alleviate
pain,
prevent
further
progression,
promote
cartilage
regeneration
bone
remodeling
in
both
OA
RA.
However,
the
effectiveness
intra-articular
injection
with
traditional
drugs
uncertain
controversial
due
issues
such
as
rapid
drug
clearance
barrier
afforded
by
dense
structure
cartilage.
Nanoparticles
can
improve
efficacy
facilitating
controlled
release,
prolonged
retention
time,
enhanced
penetration
into
tissue.
This
review
systematically
summarizes
nanoparticle-based
therapies
for
RA
management.
Firstly,
we
explore
interaction
between
nanoparticles
joints,
including
articular
fluids
cells.
followed
comprehensive
analysis
current
designed
OA/RA,
divided
two
categories
based
on
therapeutic
mechanisms:
direct
nanoparticles-based
delivery
systems.
We
highlight
nanoparticle
design
tissue/cell
targeting
release
before
discussing
challenges
efficient
treatment
their
future
clinical
translation.
anticipate
rationally
local
will
be
more
effective,
convenient,
safer
than
approach.
Nano Letters,
Год журнала:
2023,
Номер
23(9), С. 3929 - 3938
Опубликована: Апрель 27, 2023
Manufacturing
heteronanostructures
with
specific
physicochemical
characteristics
and
tightly
controllable
designs
is
very
appealing.
Herein,
we
reported
NIR-II
light-driven
dual
plasmonic
(AuNR-SiO2-Cu7S4)
antimicrobial
nanomotors
an
intended
Janus
configuration
through
the
overgrowth
of
copper-rich
Cu7S4
nanocrystals
at
only
one
high-curvature
site
Au
nanorods
(Au
NRs).
These
were
applied
for
photoacoustic
imaging
(PAI)-guided
synergistic
photothermal
photocatalytic
treatment
bacterial
infections.
Both
performance
activity
are
dramatically
improved
owing
to
strong
plasmon
coupling
between
NRs
component
enhanced
energy
transfer.
The
motion
behavior
promotes
transdermal
penetration
enhances
matter–bacteria
interaction.
More
importantly,
directional
navigation
could
be
synchronously
driven
by
light.
marriage
active
antibacterial
resulted
in
expected
good
effects
abscess
infection
mouse
model.
Oral
medication
for
ulcerative
colitis
(UC)
is
often
hindered
by
challenges
such
as
inadequate
accumulation,
limited
penetration
of
mucus
barriers,
and
the
intricate
task
mitigating
excessive
ROS
inflammatory
cytokines.
Here,
we
present
a
strategy
involving
sodium
alginate
microspheres
(SAMs)
incorporating
M2
macrophage
membrane
(M2M)-coated
Janus
nanomotors
(denominated
Motor@M2M)
targeted
treatment
UC.
SAM
provides
protective
barrier,
ensuring
that
Motor@M2M
withstands
harsh
gastric
milieu
exhibits
controlled
release.
M2M
enhances
targeting
precision
to
tissues
acts
decoy
neutralization
Catalytic
decomposition
H
ACS Nano,
Год журнала:
2024,
Номер
18(15), С. 10625 - 10641
Опубликована: Апрель 2, 2024
Development
of
nanomedicines
that
can
collaboratively
scavenge
reactive
oxygen
species
(ROS)
and
inhibit
inflammatory
cytokines,
along
with
osteogenesis
promotion,
is
essential
for
efficient
osteoarthritis
(OA)
treatment.
Herein,
we
report
the
design
a
ROS-responsive
nanomedicine
formulation
based
on
fibronectin
(FN)-coated
polymer
nanoparticles
(NPs)
loaded
azabisdimethylphoaphonate-terminated
phosphorus
dendrimers
(G4-TBP).
The
constructed
G4-TBP
NPs-FN
size
268
nm
are
stable
under
physiological
conditions,
be
specifically
taken
up
by
macrophages
through
FN-mediated
targeting,
dissociated
in
oxidative
microenvironment.
dendrimer
having
intrinsic
anti-inflammatory
property
FN
both
antioxidative
properties
display
integrated
functions
ROS
scavenging,
hypoxia
attenuation,
macrophage
M2
polarization,
thus
protecting
from
apoptosis
creating
designed
bone
immune
microenvironment
stem
cell
osteogenic
differentiation.
These
characteristics
lead
to
their
effective
treatment
an
OA
model
vivo
reduce
pathological
changes
joints
including
synovitis
inhibition
cartilage
matrix
degradation
simultaneously
promote
differentiation
repair.
developed
combining
advantages
bioactive
treat
may
immunomodulatory
therapy
different
diseases.
Abstract
Rheumatoid
arthritis
(RA)
is
a
systemic
autoimmune
disease
characterized
by
chronic
inflammation
of
the
joints
and
bone
destruction.
Because
administration
poor
targeting,
traditional
anti‐rheumatic
drugs
have
unsatisfactory
treatment
efficacy
strong
side
effects,
including
myelosuppression,
liver
or
kidney
function
damage,
malignant
tumors.
Consequently,
mesenchymal
stem
cells
(MSCs)‐involved
therapy
proposed
for
RA
as
benefit
their
immunosuppressive
tissue‐repairing
effects.
This
review
summarizes
progress
MSCs‐involved
through
suppressing
promoting
tissue
regeneration
predicts
potential
clinical
application.
Advanced Materials,
Год журнала:
2024,
Номер
36(48)
Опубликована: Окт. 6, 2024
Rheumatoid
arthritis
(RA)
represents
an
insidious
autoimmune
inflammatory
disorder
that
severely
lowers
the
life
quality
by
progressively
destructing
joint
functions
and
eventually
causing
permanent
disability,
posing
a
serious
public
health
problem.
Here,
advanced
theranostic
probe
is
introduced
integrates
activatable
second
near-infrared
(NIR-II)
fluorescence
imaging
for
precise
RA
diagnosis
with
multi-pronged
treatments.
A
novel
molecular
comprising
long-wavelength
aggregation-induced
emission
unit
manganese
carbonyl
cage
motif
synthesized,
which
enables
NIR-II
activation
concurrently
releasing
therapeutic
carbon
monoxide
(CO)
gas
in
inflamed
microenvironment.
This
self-assembles
into
biocompatible
nanoprobe,
subsequently
conjugated
anti-IL-6R
antibody
to
afford
active-targeting
ability
of
RA.
The
nanoprobe
exhibits
significant
turn-on
signal
at
lesion,
enabling
highly
sensitive
real-time
monitoring.
combination
ROS
scavenging,
on-demand
CO
release,
IL-6
signaling
blockade
results
potent
effect
synergistic
immunomodulation
impact,
significantly
alleviating
symptoms
preventing
destruction.
research
introduces
paradigm
development
high-performance,
strategies
facilitate
detection
enhanced
treatment
RA-related
diseases.
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
commonly
associated
with
the
accumulation
of
hyperactive
immune
cells
(HICs),
particularly
macrophages
pro-inflammatory
(M1)
phenotype,
accompanied
by
elevated
level
reactive
oxygen
species
(ROS),
decreased
pH
and
O2
content
in
joint
synovium.
In
this
work,
an
immunomodulatory
nanosystem
(IMN)
developed
for
RA
therapy
modulating
restoring
function
HICs
inflamed
tissues.
Manganese
tetraoxide
nanoparticles
(Mn3
O4
)
anchored
on
UiO-66-NH2
are
designed,
then
hybrid
coated
Mn-EGCG
film,
further
wrapped
HA
to
obtain
final
nanocomposite
@Mn3
/Mn-EGCG@HA
(termed
as
UMnEH).
When
UMnEH
diffuses
inflammatory
site
synovium,
stimulation
microwave
(MW)
irradiation
low
trigger
slow
dissociation
film.
Then
endogenously
overexpressed
hydrogen
peroxide
(H2
disintegrates
exposed
Mn3
NPs
promote
ROS
scavenging
generation.
Assisted
MW
irradiation,
microenvironment
down-regulates
expression
hypoxia-inducible
factor-1α
(HIF-1α).
Coupled
clearance
ROS,
it
promotes
re-polarization
M1
phenotype
into
anti-inflammatory
(M2)
macrophages.
Therefore,
multifunctional
nanoplatform,
IMN,
exhibits
promising
potential
modulate
restore
has
exciting
prospect
treatment
RA.
Periodontology 2000,
Год журнала:
2023,
Номер
94(1), С. 213 - 230
Опубликована: Окт. 12, 2023
The
use
of
biomaterials
in
regenerative
medicine
has
expanded
to
treat
various
disorders
caused
by
trauma
or
disease
orthopedics
and
dentistry.
However,
the
treatment
large
complex
bone
defects
presents
a
challenge,
leading
pressing
need
for
optimized
repair.
Recent
advances
chemical
sciences
have
enabled
incorporation
therapeutic
ions
into
grafts
enhance
their
performance.
These
ions,
such
as
strontium
(for
regeneration/osteoporosis),
copper
angiogenesis),
boron
growth),
iron
chemotaxis),
cobalt
B12
synthesis),
lithium
osteogenesis/cementogenesis),
silver
antibacterial
resistance),
magnesium
cartilage
regeneration),
among
others
(e.g.,
zinc,
sodium,
silica),
been
studied
extensively.
This
review
aims
provide
comprehensive
overview
current
knowledge
recent
developments
ion
periodontal
tissue
It
also
discusses
recently
developed
from
basic
design
clinical
application
perspective.
Additionally,
highlights
importance
precise
introduction
address
existing
limitations
challenges
combination
therapies.
Future
prospects
opportunities
development
optimization
engineering
are
emphasized.
