Engineered Macrophage Membrane-Camouflaged Nanodecoys Reshape the Infectious Microenvironment for Efficient Periodontitis Treatment DOI
Sihan Lin, Zeqian Xu, Yulan Liu

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

A vicious cycle between microbiota dysbiosis and hyperactivated inflammation, hardly disrupted by conventional therapies, remains a significant clinical challenge for periodontitis treatment. Herein, cloaking cascade catalysis system in an engineered macrophage membrane, nanodecoy-based strategy, with targeted bacteria-killing immunomodulatory abilities, is proposed reshaping the hostile microenvironment. Specifically, recombinant human antimicrobial peptide, LL-37, anchored to Toll-like receptor-enriched membrane via genetic engineering, which facilitates specific bacteria elimination efficient tissue retention of nanodecoys. Moreover, integrates L-amino acid oxidase (LAAO) hollowed manganese dioxide (hMnO2) reciprocal elevation catalytic efficiency hMnO2 LAAO, leading accelerated O2 generation under hypoxic microenvironment metabolism periodontopathogenic bacteria. Notably, nanodecoys trigger nuclear translocation NF-E2-related factor-2 (NRF2) reduce oxidative stress response rewire polarization macrophages, thereby boosting osteogenic differentiation osteoblasts. Furthermore, alveolar bone regeneration therapeutically benefits from vivo. Altogether, these results highlight attractive functions membrane-cloaked effective

Язык: Английский

Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management DOI Creative Commons
Juan Wen, Huimin Li,

Huan Dai

и другие.

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100597 - 100597

Опубликована: Фев. 26, 2023

Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic progressive inflammatory joint diseases that affect a large population worldwide. Intra-articular administration of various therapeutics is applied to alleviate pain, prevent further progression, promote cartilage regeneration bone remodeling in both OA RA. However, the effectiveness intra-articular injection with traditional drugs uncertain controversial due issues such as rapid drug clearance barrier afforded by dense structure cartilage. Nanoparticles can improve efficacy facilitating controlled release, prolonged retention time, enhanced penetration into tissue. This review systematically summarizes nanoparticle-based therapies for RA management. Firstly, we explore interaction between nanoparticles joints, including articular fluids cells. followed comprehensive analysis current designed OA/RA, divided two categories based on therapeutic mechanisms: direct nanoparticles-based delivery systems. We highlight nanoparticle design tissue/cell targeting release before discussing challenges efficient treatment their future clinical translation. anticipate rationally local will be more effective, convenient, safer than approach.

Язык: Английский

Процитировано

68

A Photo‐Therapeutic Nanocomposite with Bio‐Responsive Oxygen Self‐Supplying Combats Biofilm Infections and Inflammation from Drug‐Resistant Bacteria DOI
Yuan Zhang, Jianshuang Wu, Yao Xiao

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 33(37)

Опубликована: Май 25, 2023

Abstract The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections, especially biofilms and accompanying inflammation, has recently aroused widespread interest. Herein, a photo‐therapeutic nanocomposite with bio‐responsive oxygen (O 2 ) self‐supplying is introduced by integrating manganese dioxide (MnO nanozymes onto photosensitizer (indocyanine green, ICG)‐loaded mesoporous polydopamine nanoparticles (MPDA), namely MI‐MPDA NPs. can activate O generation in the infection microenvironment, thereby effectively alleviating biofilm hypoxia. Under near‐infrared light (NIR) irradiation, continuous supplying further boosts level singlet ( 1 ), enabling robust elimination through ‐potentiated photodynamic/photothermal therapy. Interestingly, down‐regulates factor expression inflammatory signaling pathways MnO ‐mediated reactive species scavenging, which ameliorates condition. Meanwhile, prevents M1‐phenotype switch macrophages from overexpression hypoxia‐inducible factor‐1 α (HIF‐1 prompting macrophage reprogramming toward pro‐regenerative M2‐phenotype. In mouse models subcutaneous implant‐associated caused methicillin‐resistant Staphylococcus aureus (MRSA) burn Pseudomonas aeruginosa biofilms, NIR‐irradiated not only eliminates formed but also alleviates oxidative stress drives cascade reaction immunomodulation‐wound healing. Overall, this strategy provides reliable tool for combating infections inflammation bacteria.

Язык: Английский

Процитировано

53

Drug-Free Antimicrobial Nanomotor for Precise Treatment of Multidrug-Resistant Bacterial Infections DOI

Luntao Liu,

Shuqin Li,

Kaiqiong Yang

и другие.

Nano Letters, Год журнала: 2023, Номер 23(9), С. 3929 - 3938

Опубликована: Апрель 27, 2023

Manufacturing heteronanostructures with specific physicochemical characteristics and tightly controllable designs is very appealing. Herein, we reported NIR-II light-driven dual plasmonic (AuNR-SiO2-Cu7S4) antimicrobial nanomotors an intended Janus configuration through the overgrowth of copper-rich Cu7S4 nanocrystals at only one high-curvature site Au nanorods (Au NRs). These were applied for photoacoustic imaging (PAI)-guided synergistic photothermal photocatalytic treatment bacterial infections. Both performance activity are dramatically improved owing to strong plasmon coupling between NRs component enhanced energy transfer. The motion behavior promotes transdermal penetration enhances matter–bacteria interaction. More importantly, directional navigation could be synchronously driven by light. marriage active antibacterial resulted in expected good effects abscess infection mouse model.

Язык: Английский

Процитировано

48

Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis DOI Creative Commons
Ruifeng Luo, J. Liu, Qian Cheng

и другие.

Science Advances, Год журнала: 2024, Номер 10(26)

Опубликована: Июнь 28, 2024

Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task mitigating excessive ROS inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)-coated Janus nanomotors (denominated Motor@M2M) targeted treatment UC. SAM provides protective barrier, ensuring that Motor@M2M withstands harsh gastric milieu exhibits controlled release. M2M enhances targeting precision to tissues acts decoy neutralization Catalytic decomposition H

Язык: Английский

Процитировано

28

Nanoparticle-Mediated Multiple Modulation of Bone Microenvironment To Tackle Osteoarthritis DOI
Mengsi Zhan, Huxiao Sun, Zhiqiang Wang

и другие.

ACS Nano, Год журнала: 2024, Номер 18(15), С. 10625 - 10641

Опубликована: Апрель 2, 2024

Development of nanomedicines that can collaboratively scavenge reactive oxygen species (ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential for efficient osteoarthritis (OA) treatment. Herein, we report the design a ROS-responsive nanomedicine formulation based on fibronectin (FN)-coated polymer nanoparticles (NPs) loaded azabisdimethylphoaphonate-terminated phosphorus dendrimers (G4-TBP). The constructed G4-TBP NPs-FN size 268 nm are stable under physiological conditions, be specifically taken up by macrophages through FN-mediated targeting, dissociated in oxidative microenvironment. dendrimer having intrinsic anti-inflammatory property FN both antioxidative properties display integrated functions ROS scavenging, hypoxia attenuation, macrophage M2 polarization, thus protecting from apoptosis creating designed bone immune microenvironment stem cell osteogenic differentiation. These characteristics lead to their effective treatment an OA model vivo reduce pathological changes joints including synovitis inhibition cartilage matrix degradation simultaneously promote differentiation repair. developed combining advantages bioactive treat may immunomodulatory therapy different diseases.

Язык: Английский

Процитировано

20

Arthritic Microenvironment Actuated Nanomotors for Active Rheumatoid Arthritis Therapy DOI Creative Commons
Cong Xu,

Yuejun Jiang,

Hong Wang

и другие.

Advanced Science, Год журнала: 2022, Номер 10(4)

Опубликована: Ноя. 14, 2022

Increasing O

Язык: Английский

Процитировано

64

Manganese‐Based Immunomodulatory Nanocomposite with Catalase‐Like Activity and Microwave‐Enhanced ROS Elimination Ability for Efficient Rheumatoid Arthritis Therapy DOI Open Access
Xiaotong Chen, Lianying Zhang,

Haifeng Zeng

и другие.

Small, Год журнала: 2023, Номер 19(50)

Опубликована: Авг. 26, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease commonly associated with the accumulation of hyperactive immune cells (HICs), particularly macrophages pro-inflammatory (M1) phenotype, accompanied by elevated level reactive oxygen species (ROS), decreased pH and O2 content in joint synovium. In this work, an immunomodulatory nanosystem (IMN) developed for RA therapy modulating restoring function HICs inflamed tissues. Manganese tetraoxide nanoparticles (Mn3 O4 ) anchored on UiO-66-NH2 are designed, then hybrid coated Mn-EGCG film, further wrapped HA to obtain final nanocomposite @Mn3 /Mn-EGCG@HA (termed as UMnEH). When UMnEH diffuses inflammatory site synovium, stimulation microwave (MW) irradiation low trigger slow dissociation film. Then endogenously overexpressed hydrogen peroxide (H2 disintegrates exposed Mn3 NPs promote ROS scavenging generation. Assisted MW irradiation, microenvironment down-regulates expression hypoxia-inducible factor-1α (HIF-1α). Coupled clearance ROS, it promotes re-polarization M1 phenotype into anti-inflammatory (M2) macrophages. Therefore, multifunctional nanoplatform, IMN, exhibits promising potential modulate restore has exciting prospect treatment RA.

Язык: Английский

Процитировано

27

Ion incorporation into bone grafting materials DOI Open Access
Qin Zhao, Yueqi Ni,

Hongjiang Wei

и другие.

Periodontology 2000, Год журнала: 2023, Номер 94(1), С. 213 - 230

Опубликована: Окт. 12, 2023

The use of biomaterials in regenerative medicine has expanded to treat various disorders caused by trauma or disease orthopedics and dentistry. However, the treatment large complex bone defects presents a challenge, leading pressing need for optimized repair. Recent advances chemical sciences have enabled incorporation therapeutic ions into grafts enhance their performance. These ions, such as strontium (for regeneration/osteoporosis), copper angiogenesis), boron growth), iron chemotaxis), cobalt B12 synthesis), lithium osteogenesis/cementogenesis), silver antibacterial resistance), magnesium cartilage regeneration), among others (e.g., zinc, sodium, silica), been studied extensively. This review aims provide comprehensive overview current knowledge recent developments ion periodontal tissue It also discusses recently developed from basic design clinical application perspective. Additionally, highlights importance precise introduction address existing limitations challenges combination therapies. Future prospects opportunities development optimization engineering are emphasized.

Язык: Английский

Процитировано

27

Mesenchymal Stem Cells‐Involved Strategies for Rheumatoid Arthritis Therapy DOI Creative Commons
Chaoyang Li, Yifu Sun, Weiguo Xu

и другие.

Advanced Science, Год журнала: 2024, Номер 11(24)

Опубликована: Март 13, 2024

Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the joints and bone destruction. Because administration poor targeting, traditional anti‐rheumatic drugs have unsatisfactory treatment efficacy strong side effects, including myelosuppression, liver or kidney function damage, malignant tumors. Consequently, mesenchymal stem cells (MSCs)‐involved therapy proposed for RA as benefit their immunosuppressive tissue‐repairing effects. This review summarizes progress MSCs‐involved through suppressing promoting tissue regeneration predicts potential clinical application.

Язык: Английский

Процитировано

18

Microenvironment‐Activatable Probe for Precise NIR‐II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis DOI Open Access
Yuan Zhang, Dongfang Liu, Wenwen Chen

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(48)

Опубликована: Окт. 6, 2024

Rheumatoid arthritis (RA) represents an insidious autoimmune inflammatory disorder that severely lowers the life quality by progressively destructing joint functions and eventually causing permanent disability, posing a serious public health problem. Here, advanced theranostic probe is introduced integrates activatable second near-infrared (NIR-II) fluorescence imaging for precise RA diagnosis with multi-pronged treatments. A novel molecular comprising long-wavelength aggregation-induced emission unit manganese carbonyl cage motif synthesized, which enables NIR-II activation concurrently releasing therapeutic carbon monoxide (CO) gas in inflamed microenvironment. This self-assembles into biocompatible nanoprobe, subsequently conjugated anti-IL-6R antibody to afford active-targeting ability of RA. The nanoprobe exhibits significant turn-on signal at lesion, enabling highly sensitive real-time monitoring. combination ROS scavenging, on-demand CO release, IL-6 signaling blockade results potent effect synergistic immunomodulation impact, significantly alleviating symptoms preventing destruction. research introduces paradigm development high-performance, strategies facilitate detection enhanced treatment RA-related diseases.

Язык: Английский

Процитировано

16