Microchemical Journal, Год журнала: 2025, Номер 213, С. 113683 - 113683
Опубликована: Апрель 17, 2025
Язык: Английский
Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(11)
Опубликована: Дек. 12, 2023
Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance
Язык: Английский
Процитировано
51
Coordination Chemistry Reviews, Год журнала: 2024, Номер 516, С. 215986 - 215986
Опубликована: Июнь 2, 2024
Язык: Английский
Процитировано
27
Advanced Materials, Год журнала: 2024, Номер 36(31)
Опубликована: Май 21, 2024
Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced
Язык: Английский
Процитировано
25
The Journal of Physical Chemistry B, Год журнала: 2024, Номер 128(5), С. 1121 - 1138
Опубликована: Янв. 24, 2024
Human serum albumin (HSA) acts as a repository and transporter of substances in the blood. An abnormal concentration may indicate occurrence liver- kidney-related diseases, which has attracted people to investigate precise quantification HSA body fluids. Fluorescent probes can combine with covalently or noncovalently quantify urine plasma. Moreover, combined improve its photophysical properties; probe-HSA been applied real-time monitoring photothermal photodynamic therapy
Язык: Английский
Процитировано
21
Advanced Science, Год журнала: 2022, Номер 10(3)
Опубликована: Ноя. 24, 2022
The signal-to-noise ratio (SNR) is one of the key features a fluorescent probe and that often defines its potential utility for in vivo labeling analyte detection applications. Here, it reported introducing pyridine group into traditional cyanine-7 dyes an asymmetric manner provides series tunable NIR (Cy-Mu-7) characterized by enhanced Stokes shifts (≈230 nm) compared to parent cyanine 7 dye (<25 nm). observed shift increase ascribed symmetry breaking Cy-Mu-7 core reduction extent conjugation. fluorescence signals are upon confinement within hydrophobic cavity albumin or via spontaneous encapsulation micelles aqueous media. Utilizing Cy-Mu-7, ultra-fast kidney mice realized, found liver injury will aggravate burden monitoring intensity liver. In addition, could be used as efficient chemiluminescence resonance energy transfer acceptor reaction between H
Язык: Английский
Процитировано
43
TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 167, С. 117272 - 117272
Опубликована: Сен. 7, 2023
Язык: Английский
Процитировано
36
Chemical Communications, Год журнала: 2023, Номер 60(7), С. 835 - 838
Опубликована: Дек. 7, 2023
An ICT-switched fluorescent probe has been developed for the visualization of lipid accumulation and hypochlorous acid in droplets during ferroptosis.
Язык: Английский
Процитировано
30
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(16)
Опубликована: Фев. 27, 2024
Abnormal physiological processes and diseases can lead to content or activity fluctuations of biocomponents in organelles whole blood. However, precise monitoring these abnormalities remains extremely challenging due the insufficient sensitivity accuracy available fluorescence probes, which be attributed background arising from two sources, 1) biocomponent autofluorescence (BCAF) 2) probe intrinsic (PIF). To overcome obstacles, we have re-engineered far-red NIR II rhodol derivatives that possess weak BCAF interference. And a series "zero" PIF sensing-platforms were created by systematically regulating open-loop/spirocyclic forms. Leveraging advancements, devised various ultra-sensitive indicators, achieving substantial boosts (190 1300-fold). Among 8-LAP demonstrated accurate tracking quantifying leucine aminopeptidase (LAP) blood at stages tumor metastasis. Furthermore, coupling with an endoplasmic reticulum-targeting element enabled detection ERAP1 HCT116 cells p53 abnormalities. This delicate design eliminating provides insights into enhancing existing probes toward imaging abnormal diseases.
Язык: Английский
Процитировано
10
Chemical Science, Год журнала: 2025, Номер 16(10), С. 4490 - 4500
Опубликована: Янв. 1, 2025
Bridging the disparity between traditional surgical resection imaging and ex vivo histopathology, fluorescence is considered a promising tool in disease diagnosis navigation. Nevertheless, its usefulness undermined by variability of single-wavelength signals limited penetration NIR-I (650-900 nm) bioimaging. In this work, we present novel NIR-II ratiometric fluorescent probe (CFC-GSH) with γ-glutamyl transpeptidase (GGT) sensitivity for multifunctional This leverages GSH-capped anionic cyanine, advantages high brightness, excellent photostability, specificity favourable biocompatibility. CFC-GSH exhibits an intrinsically stable signal prior to triggering, which can be utilized systemic circulation vessel outlining microvascular imaging. At tumour site GGT over expression, intramolecular S,N-rearrangement would initiate conversion sulphur-substituted cyanine amino-substituted resulting significant emission shift 270 nm. Using dual-channel changes, effectively differentiates subcutaneous hepatocellular carcinoma (HCC) normal tissue precisely localizes metastatic HCC tumours abdominal cavity. These results reveal that potential as multiprospective candidate screening diagnostic various biological scenarios.
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Abstract Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic imaging efficient therapeutic capabilities. In this work, a supramolecular strategy is employed construct molecular pair agent via the direct self‐assembly two cyanines, C5TNa (anionic) Cy‐Et (cationic). The Coulombic interactions between facilitate formation complementary cyanine (C5T‐ET) creation CT‐J‐type aggregates in water. This results completely quenched fluorescence significantly enhances nonradiative deactivation (≈22 ps), leading 3.3‐fold increase photothermal conversion efficiency 7.1‐fold enhancement response compared indocyanine green (ICG). As result, J‐type aggregate demonstrates high capability remarkable antitumor efficacy vivo, highlighting its potential clinical applications. work provides strong experimental evidence superior performance enhancing photosensitization response. It believed will propel advancement controllable dye J‐aggregates contribute practical implementation phototherapy vivo.
Язык: Английский
Процитировано
1