Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing

Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(11)

Опубликована: Дек. 12, 2023

Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance

Язык: Английский

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Small molecular cyanine dyes for phototheranostics

Coordination Chemistry Reviews, Год журнала: 2024, Номер 516, С. 215986 - 215986

Опубликована: Июнь 2, 2024

Язык: Английский

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Neutral Cyanine: Ultra‐Stable NIR‐II Merocyanines for Highly Efficient Bioimaging and Tumor‐Targeted Phototheranostics

Advanced Materials, Год журнала: 2024, Номер 36(31)

Опубликована: Май 21, 2024

Fluorescence imaging (FLI)-guided phototheranostics using emission from the second near-infrared (NIR-II) window show significant potential for cancer diagnosis and treatment. Clinical imaging-used polymethine ionic indocyanine green (ICG) dye is widely adopted NIR fluorescence imaging-guided photothermal therapy (PTT) research due to its exceptional photophysical properties. However, ICG has limitations such as poor photostability, low conversion efficiency (PCE), short-wavelength peak, liver-targeting issues, which restrict wider use. In this study, two derivatives are transformed into neutral merocyanines (mCy) achieve much-enhanced performance NIR-II phototheranostics. Initial designs of dyes similar drawbacks in terms photostability performance. One modified molecules, mCy890, shows significantly improved stability, an peak over 1000 nm, a high PCE 51%, all considerably outperform ICG. vivo studies demonstrate that nanoparticles mCy890 can effectively accumulate at tumor sites guided by imaging. This provides valuable insights development enhanced

Язык: Английский

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Development of Human Serum Albumin Fluorescent Probes in Detection, Imaging, and Disease Therapy

The Journal of Physical Chemistry B, Год журнала: 2024, Номер 128(5), С. 1121 - 1138

Опубликована: Янв. 24, 2024

Human serum albumin (HSA) acts as a repository and transporter of substances in the blood. An abnormal concentration may indicate occurrence liver- kidney-related diseases, which has attracted people to investigate precise quantification HSA body fluids. Fluorescent probes can combine with covalently or noncovalently quantify urine plasma. Moreover, combined improve its photophysical properties; probe-HSA been applied real-time monitoring photothermal photodynamic therapy

Язык: Английский

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Enlarging the Stokes Shift by Weakening the π‐Conjugation of Cyanines for High Signal‐to‐Noise Ratiometric Imaging

Advanced Science, Год журнала: 2022, Номер 10(3)

Опубликована: Ноя. 24, 2022

The signal-to-noise ratio (SNR) is one of the key features a fluorescent probe and that often defines its potential utility for in vivo labeling analyte detection applications. Here, it reported introducing pyridine group into traditional cyanine-7 dyes an asymmetric manner provides series tunable NIR (Cy-Mu-7) characterized by enhanced Stokes shifts (≈230 nm) compared to parent cyanine 7 dye (<25 nm). observed shift increase ascribed symmetry breaking Cy-Mu-7 core reduction extent conjugation. fluorescence signals are upon confinement within hydrophobic cavity albumin or via spontaneous encapsulation micelles aqueous media. Utilizing Cy-Mu-7, ultra-fast kidney mice realized, found liver injury will aggravate burden monitoring intensity liver. In addition, could be used as efficient chemiluminescence resonance energy transfer acceptor reaction between H

Язык: Английский

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Coumarin-hemicyanine-based far-red to near-infrared fluorescent probes: A new generation of fluorescent probe design platform

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 167, С. 117272 - 117272

Опубликована: Сен. 7, 2023

Язык: Английский

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An ICT-switched fluorescent probe for visualizing lipid and HClO in lipid droplets during ferroptosis

Chemical Communications, Год журнала: 2023, Номер 60(7), С. 835 - 838

Опубликована: Дек. 7, 2023

An ICT-switched fluorescent probe has been developed for the visualization of lipid accumulation and hypochlorous acid in droplets during ferroptosis.

Язык: Английский

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“Zero” Intrinsic Fluorescence Sensing‐Platforms Enable Ultrasensitive Whole Blood Diagnosis and In Vivo Imaging

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(16)

Опубликована: Фев. 27, 2024

Abnormal physiological processes and diseases can lead to content or activity fluctuations of biocomponents in organelles whole blood. However, precise monitoring these abnormalities remains extremely challenging due the insufficient sensitivity accuracy available fluorescence probes, which be attributed background arising from two sources, 1) biocomponent autofluorescence (BCAF) 2) probe intrinsic (PIF). To overcome obstacles, we have re-engineered far-red NIR II rhodol derivatives that possess weak BCAF interference. And a series "zero" PIF sensing-platforms were created by systematically regulating open-loop/spirocyclic forms. Leveraging advancements, devised various ultra-sensitive indicators, achieving substantial boosts (190 1300-fold). Among 8-LAP demonstrated accurate tracking quantifying leucine aminopeptidase (LAP) blood at stages tumor metastasis. Furthermore, coupling with an endoplasmic reticulum-targeting element enabled detection ERAP1 HCT116 cells p53 abnormalities. This delicate design eliminating provides insights into enhancing existing probes toward imaging abnormal diseases.

Язык: Английский

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Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing

Angewandte Chemie, Год журнала: 2023, Номер 136(11)

Опубликована: Дек. 12, 2023

Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance

Язык: Английский

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In-situ gastritis diagnosis by an oral-administration NIR fluorescent probe with a large Stokes shift and high signal-to-noise ratio

Chemical Engineering Journal, Год журнала: 2023, Номер 464, С. 142767 - 142767

Опубликована: Апрель 3, 2023

Язык: Английский

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