Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

ACS Nano, Год журнала: 2024, Номер 18(22), С. 14085 - 14122

Опубликована: Май 22, 2024

Infectious diseases pose a serious threat and substantial economic burden on global human public health security, especially with the frequent emergence of multidrug-resistant (MDR) bacteria in clinical settings. In response to this urgent need, various photobased anti-infectious therapies have been reported lately. This Review explores discusses several photochemical targeted antibacterial therapeutic strategies for addressing bacterial infections regardless their antibiotic susceptibility. contrast conventional therapies, these approaches facilitate precise targeting pathogenic and/or infectious microenvironments, effectively minimizing toxicity mammalian cells surrounding healthy tissues. The highlighted include photodynamic therapy, photocatalytic photothermal endogenous pigments-based photobleaching polyphenols-based photo-oxidation therapy. comprehensive exploration aims offer updated information development effective, convenient, safe, alternative counter growing MDR future.

Язык: Английский

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Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis

Theranostics, Год журнала: 2024, Номер 14(10), С. 4014 - 4057

Опубликована: Янв. 1, 2024

Background:The comprehensive management of diabetic bone defects remains a substantial clinical challenge due to the hostile regenerative microenvironment characterized by aggravated inflammation, excessive reactive oxygen species (ROS), bacterial infection, impaired angiogenesis, and unbalanced homeostasis.Thus, an advanced multifunctional therapeutic platform capable simultaneously achieving immune regulation, elimination, tissue regeneration is urgently designed for augmented under pathological milieu.Methods Results: Herein, photoactivated soft-hard combined scaffold system (PGCZ) was engineered introducing polydopamine-modified zeolitic imidazolate framework-8-loaded double-network hydrogel (soft matrix component) into 3D-printed poly(ε-caprolactone) (PCL) (hard component).The versatile PGCZ based on PCL thus prepared features highly extracellular matrix-mimicking microstructure, suitable biodegradability mechanical properties, excellent photothermal performance, allowing long-term structural stability support regeneration.Under periodic near-infrared (NIR) irradiation, localized effect triggers on-demand release Zn 2+ , which, together with repeated mild hyperthermia, collectively accelerates proliferation osteogenic differentiation preosteoblasts potently inhibits growth biofilm formation.Additionally, also presents outstanding immunomodulatory ROS scavenging capacities, which regulate M2 polarization macrophages drive functional cytokine secretion, leading pro-regenerative in situ enhanced vascularization.In vivo experiments further demonstrated that conjunction activity remarkably attenuated local inflammatory cascade, initiated endogenous stem cell recruitment neovascularization, orchestrated osteoblast/osteoclast balance, ultimately accelerating regeneration. Ivyspring

Язык: Английский

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Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing

Bioactive Materials, Год журнала: 2024, Номер 44, С. 131 - 151

Опубликована: Окт. 15, 2024

Язык: Английский

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Multifunctional polysaccharide/metal/polyphenol double-crosslinked hydrogel for infected wound

Carbohydrate Polymers, Год журнала: 2024, Номер 332, С. 121912 - 121912

Опубликована: Фев. 4, 2024

Язык: Английский

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Enhanced Mechanical Strength and Sustained Drug Release in Carrier‐Free Silver‐Coordinated Anthraquinone Natural Antibacterial Anti‐Inflammatory Hydrogel for Infectious Wound Healing

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Май 10, 2024

The persistent challenge of healing infectious wounds and the rise bacterial resistance represent significant hurdles in contemporary medicine. In this study, based on natural small molecule drug Rhein self-assembly to form hydrogels coordinate assembly with silver ions (Ag

Язык: Английский

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Hydrogel Wound Dressings Accelerating Healing Process of Wounds in Movable Parts

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6610 - 6610

Опубликована: Июнь 15, 2024

Skin is the largest organ in human body and requires proper dressing to facilitate healing after an injury. Wounds on movable parts, such as elbow, knee, wrist, neck, usually undergo delayed inefficient due frequent movements. To better accommodate wounds, a variety of functional hydrogels have been successfully developed used flexible wound dressings. On one hand, mechanical properties, adhesion, stretchability, self-healing, make these suitable for mobile wounds promote process; other bioactivities, antibacterial antioxidant performance, could further accelerate process. In this review, we focus recent advances hydrogel-based dressings propose challenges perspectives

Язык: Английский

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Antioxidant, hemostatic, and injectable hydrogels with photothermal antibacterial activity to accelerate full-thickness wound regeneration

New Journal of Chemistry, Год журнала: 2024, Номер 48(17), С. 7761 - 7778

Опубликована: Янв. 1, 2024

Developing injectable hydrogel dressings with multifunctional properties, including antibacterial and antioxidant ability, good mechanical properties to treat infected full-thickness skin wounds is of particular importance in clinical applications.

Язык: Английский

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Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing

Biomaterials, Год журнала: 2025, Номер unknown, С. 123134 - 123134

Опубликована: Янв. 1, 2025

Язык: Английский

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Bioinspired Adhesive Hydrogel Platform with Photothermal Antimicrobial, Antioxidant, and Angiogenic Properties for Whole-Process Management of Diabetic Wounds

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Diabetic wound healing remains a major challenge in modern medicine. The persistent inflammation and immune dysfunction hinder angiogenesis by producing excessive ROS increasing the susceptibility to bacterial infection. In this study, we developed an integrated strategy for whole-process management of diabetic wounds based on bioinspired adhesive hydrogel platform with hemostasis, photothermal antimicrobial, antioxidant, anti-inflammatory, angiogenic properties. A composite (termed AQTGF) using poly(acrylic acid) (PAA) quaternized chitosan (QCS) as backbone materials loaded TA-Gd/Fe-bimetallic-phenolic coordination polymer was prepared. AQTGF displayed favorable mechanical properties, self-healing capabilities, adhesion characteristics, response performance. vitro experiments demonstrated that exhibits excellent antimicrobial capacity angiogenic, M2 macrophage phenotype polarizing addition, rat tail amputation liver hemostasis had Moreover, vivo studies have indicated can facilitate accelerating epidermal growth, promoting collagen deposition, modulating polarization, inhibiting inflammation, angiogenesis. conclusion, study provides adaptable holds promise treatment chronic wounds.

Язык: Английский

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Manipulating gelatinization, retrogradation, and hydrogel properties of potato starch through calcium chloride-controlled crosslinking and crystallization behavior

Carbohydrate Polymers, Год журнала: 2025, Номер 357, С. 123371 - 123371

Опубликована: Фев. 18, 2025

Язык: Английский

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