Journal of Materials Chemistry B, Год журнала: 2023, Номер 12(2), С. 475 - 488
Опубликована: Дек. 1, 2023
Pluronic F127 modified silk fibroin film could load different types of antibacterial agents to accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria and facilitating angiogenesis re-epithelialization.
Язык: Английский
Advanced Science, Год журнала: 2023, Номер 10(16)
Опубликована: Апрель 14, 2023
Polyacrylic acid (PAA) and its derivatives are commonly used as essential matrices in wound dressings, but their weak wet adhesion restricts the clinical application. To address this issue, a PAA-based coacervate hydrogel with strong capability is fabricated through facile mixture of PAA copolymers isoprenyl oxy poly(ethylene glycol) ether tannic (TA). The segments on prevent electrostatic repulsion among ionized carboxyl groups absorbed TA to form coacervates. provides solid dry substrates via multifarious interactions, which endows an adhesive strength skin 23.4 kPa 70% underwater. This achieves desirable self-healing extensible properties suitable for frequently moving joints. These investigations prove that has antibacterial activity, facilitates fibroblast migration, modulates M1/M2 polarization macrophages. In vivo hemorrhage experiments further confirm dramatically shortens hemostatic time from hundreds tens seconds. addition, full-thickness defect demonstrate best therapeutic effect by significantly promoting collagen deposition, angiogenesis, epithelialization. results promising dressing medical translation.
Язык: Английский
Процитировано
96
Biomedical Materials, Год журнала: 2024, Номер 19(3), С. 035004 - 035004
Опубликована: Фев. 16, 2024
The block copolymer micelles and natural biopolymers were utilized to form layer-by-layer (LbL) films via electrostatic interaction, which able effectively load controllably release favipiravir, a potential drug for the treatment of coronavirus epidemic. LbL demonstrated reversible swelling/shrinking behavior along with manipulation temperature, could also maintain integrity in structure morphology. Due dehydration environmentally responsive building blocks, rate from was decelerated by elevating environmental temperature ionic strength. In addition, pulsed favipiravir observed multilayer under trigger ensured precise control content therapeutic reagents at desired time point. nanoparticle-based be used on-demand
Язык: Английский
Процитировано
53
Aggregate, Год журнала: 2023, Номер 5(1)
Опубликована: Окт. 25, 2023
Abstract For more than a decade, the discovery of liquid–liquid phase separation within living organisms has prompted colloid scientists to understand connection between coacervate functionality, behavior, and dynamics at multidisciplinary level. Although protein–polysaccharide was first system in which coacervation phenomenon discovered is widely used food systems, state relaxation complex coacervates (PPCC) have rarely been discussed previously. Consequently, this review aims unravel relationship PPCC dynamics, thermodynamics, molecular architecture, applications, states past studies. Looking ahead, solving way architecture spreads macro‐functionality, that is, establishing architecture–dynamics–application, will catalyze novel advancements research field foods biomaterials.
Язык: Английский
Процитировано
47
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 11, 2024
Abstract The continuously growing utilization of wound healing materials and skin bioelectronics urges the development flexible hydrogels for personal therapy health management. Versatile conductive prepared from natural biomass are ideal candidates as one promising solutions chronic Here, study proposes a kind robust (strain: 1560.8%), adhesive, self‐healing, injectable, antibacterial (sterilization rate: 99%), near‐infrared (NIR) photothermal responsive, biocompatible, hydrogel (CPPFe@TA) composed carboxymethyl cellulose tannic acid/iron ion complex (TA@Fe 3+ ), featuring rapid self‐assembly tunable crosslinking time. TA@Fe facilitated self‐catalysis polymerization reaction, time could be controlled by adjusting Fe concentration. Under NIR irradiation, exhibited remarkable performance. In full‐thickness defect repair experiment on mice, dressing significantly enhanced healing. After 14 days, rate (95.49%) CPPFe@TA3 + treatment greatly exceeded that commercial dressings. Meanwhile, has good electrical conductivity thermo‐responsiveness, making them in physiological signal monitoring rehabilitation exercise This work therefore offers strategy developing versatile biomass‐based hydrogels, which is expected to applicable integrated regenerative bioelectronics.
Язык: Английский
Процитировано
22
Small, Год журнала: 2024, Номер 20(23)
Опубликована: Март 10, 2024
Abstract Wounds in harsh environments can face long‐term inflammation and persistent infection, which slow healing. Wound spray is a product that be rapidly applied to large irregularly dynamic wounds, quickly form protective film situ inhibit external environmental infection. In this study, biodegradable A B combined multi‐functional hydrogel developed with methacrylate‐modified chitosan (CSMA 1st ) ferulic acid (FA) as type raw materials oxidized Bletilla striata polysaccharide (OBSP) materials. The precursor CSMA ‐FA/OBSP (CSOB‐FA formed by the self‐cross‐linking of Schiff base bonds, CSMA‐FA/OBSP (CSOB‐FA) after UV–vis light, so fits wound. Rapid spraying curing provide sufficient flexibility rapidity for wounds has good injectability, adhesive, mechanical strength. rats miniature pigs, shrink promote healing infected enrichment fibrocyte populations. Therefore, multifunctional protect irregular prevent wound infection secondary injury, used safe effective treatment, prospect development.
Язык: Английский
Процитировано
18
Advanced Functional Materials, Год журнала: 2024, Номер 34(29)
Опубликована: Фев. 29, 2024
Abstract Surgical adhesives are crucial for achieving rapid hemostasis and immediate wound management during clinical interventions. However, developing a tissue adhesive that combines instant strength with biodegradability in dynamic, wet, or hemorrhagic biological environments remains persistent challenge. Here, biodegradable supramolecular robust adhesion to wet surfaces within 5 s is presented. The distinctive synergy of surface‐rich groups the hydrophobic main chain enables surmount hydration layer on surface, ensuring adhesion. Importantly, internal structure this significantly contributes its exceptional holding strength. Additionally, vivo experiments using rat liver incision model skin injury conducted. These demonstrate effectiveness emergency management. Consequently, exhibits significant potential surgical applications, addressing critical needs urgent scenarios potentially making valuable contributions medical field.
Язык: Английский
Процитировано
17
Advances in Colloid and Interface Science, Год журнала: 2025, Номер 339, С. 103425 - 103425
Опубликована: Фев. 15, 2025
Язык: Английский
Процитировано
3
Carbohydrate Polymers, Год журнала: 2023, Номер 327, С. 121677 - 121677
Опубликована: Дек. 12, 2023
Язык: Английский
Процитировано
32
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(39), С. 45676 - 45688
Опубликована: Сен. 21, 2023
Adhesives with robust but readily detachable wet tissue adhesion are of great significance for wound closure. Polyelectrolyte complex adhesive (PECA) is an important adhesive. However, its relatively weak cohesive and strength cannot satisfy clinical applications. Herein, modified tannic acid (mTA) a catechol group, long alkyl hydrophobic chain, phenyl group was prepared first, then, it mixed acrylic (AA) polyethylenimine (PEI), followed by UV photopolymerization to make hydrogel tough cohesion strength. The has strong interfacial toughness ∼1552 J/m2, good mechanical properties (∼7220 kPa strength, ∼873% strain, ∼33,370 kJ/m3 toughness), bursting pressure ∼1575 mmHg on porcine skin. can realize quick effective various biological tissues including skin, liver, kidney, heart be changed easily triggering urea solution avoid damage or uncomfortable pain the patient. This biosafe very promising closure may provide new ideas design adhesives.
Язык: Английский
Процитировано
26
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 268, С. 131643 - 131643
Опубликована: Апрель 21, 2024
Язык: Английский
Процитировано
15