Seminars in Cancer Biology,
Год журнала:
2024,
Номер
109, С. 10 - 24
Опубликована: Дек. 25, 2024
Pancreatic
ductal
adenocarcinoma
(PDAC)
has
one
of
the
worst
prognoses
all
common
solid
cancers.
For
large
majority
PDAC
patients,
only
systemic
therapies
with
very
limited
efficacy
are
indicated.
In
addition,
immunotherapies
have
not
brought
advances
seen
in
other
cancer
types.
Several
key
characteristics
contribute
to
poor
treatment
outcomes,
and
this
review,
we
will
discuss
how
these
best
captured
currently
available
ex
vivo
or
vitro
model
systems.
instance,
is
hallmarked
by
a
highly
desmoplastic
immune-suppressed
tumor
microenvironment
that
impacts
disease
progression
therapy
resistance.
Also,
differences
biology
exist
between
within
tumors,
complicating
decisions.
Furthermore,
high
propensity
for
locally
invasive
metastatic
growth.
The
use
animal
models
often
desirable
feasible
several
systems
been
developed,
such
as
organotypic
cocultures
tissue
slices,
among
others.
However,
absence
full
host
organism
ability
accurately
capture
outcomes
PDAC.
We
caveats
advantages
context
PDAC's
provide
recommendations
on
choice
possibilities
optimization.
These
considerations
should
be
researchers
aiming
study
setting.
Advanced Materials,
Год журнала:
2024,
Номер
36(28)
Опубликована: Май 15, 2024
Nerve
guidance
conduits
(NGCs)
are
considered
as
promising
treatment
strategy
and
frontier
trend
for
peripheral
nerve
regeneration,
while
their
therapeutic
outcomes
limited
by
the
lack
of
controllable
drug
delivery
available
physicochemical
cues.
Herein,
novel
aligned
piezoelectric
nanofibers
derived
hydrogel
NGCs
with
ultrasound
(US)-triggered
electrical
stimulation
(ES)
release
repairing
injury
proposed.
The
inner
layer
is
barium
titanate
nanoparticles
(BTNPs)-doped
polyvinylidene
fluoride-trifluoroethylene
[BTNPs/P(VDF-TrFE)]
electrospinning
improved
piezoelectricity
orientation.
outer
side
thermoresponsive
poly(N-isopropylacrylamide)
hybrid
bioactive
encapsulation.
Such
can
not
only
induce
neuronal-oriented
extension
promote
neurite
outgrowth
US-triggered
wireless
ES,
but
also
realize
growth
factor
shrinkage
under
heating.
Thus,
NGC
positively
accelerate
functional
recovery
axonal
regeneration
rat
models
long
sciatic
defects.
It
believed
that
proposed
US-responsive
will
find
important
applications
in
clinic
neural
tissue
engineering.
Fibrous
scaffolds
have
shown
their
advantages
in
tissue
engineering,
such
as
peripheral
nerve
regeneration,
while
most
of
the
existing
fiber-shaped
are
with
simple
structures,
and
vitro
performance
for
regeneration
lacks
systematic
analysis.
Here,
novel
nerve-on-a-chip
derived
biomimicking
microfibers
presented.
The
controllable
core-shell
structures
functionalities
generated
through
capillary
microfluidic
devices.
By
integrating
these
into
a
multitrack-architectured
chip,
coculturing
them
cells
well
gradient
bioactive
elements,
capabilities
systematically
assessing
performances
fiber
formation
hollow
at
level
is
constructed.
Based
on
rat
sciatic
injury
model,
rapid
promotion
ability
demonstrated
optimized
function
recovery
vivo,
which
implies
credibility
evaluation
regeneration.
Thus,
it
convinced
that
organ-on-a-chip
will
undoubtedly
open
up
new
chapter
evaluating
biological
vivo
engineering.
Macromolecular Bioscience,
Год журнала:
2024,
Номер
24(5)
Опубликована: Янв. 21, 2024
Peripheral
nerve
injuries
(PNI)
represent
a
prevalent
and
severe
category
of
damage
resulting
from
traumatic
incidents.
Predominantly,
the
deficiency
in
regeneration
can
be
ascribed
to
enduring
inflammatory
reactions,
hence
imposing
substantial
clinical
implications
for
patients.
Fisetin,
flavonoid
derived
plants,
is
naturally
present
an
array
vegetables
fruits,
including
strawberries,
apples,
onions,
cucumbers.
It
exhibits
immunomodulatory
properties
through
reduction
inflammation
oxidative
stress.
In
research,
defect
addressed
first
time
utilizing
scaffold
primed
controlled
fisetin
release.
this
regard,
fisetin-loaded
chitosan
hydrogels
are
incorporated
into
lumen
polycaprolactone
(PCL)
guide
conduits
(NGCs).
The
hydrogel
maintained
steady
release
appropriate
dosage.
study
outcomes
indicated
that
fisetin/chitosan/polycaprolactone
(FIS/CS/PCL)
NGCs
amplified
Schwann
cell
proliferation
neural
expression,
curtailed
stress,
alleviated
inflammation,
improved
functions,
electrophysiological
properties,
morphology.
This
pioneering
has
potential
contribute
significantly
field
neuroengineering.
Abstract
Spider
silk,
possessing
exceptional
combination
properties,
is
classified
as
a
bio‐gel
fiber.
Thereby,
it
serves
valuable
origin
of
inspiration
for
the
advancement
various
artificial
gel
fiber
materials
with
distinct
functionalities.
Gel
fibers
exhibit
promising
potential
utilization
in
diverse
fields,
including
smart
textiles,
muscle,
tissue
engineering,
and
strain
sensing.
However,
there
are
still
numerous
challenges
improving
performance
functionalizing
applications
spider
silk‐inspired
fibers.
Thus,
to
gain
penetrating
insight
into
bioinspired
fibers,
this
review
provided
comprehensive
overview
encompassing
three
key
aspects:
fundamental
design
concepts
implementing
strategies
properties
strengthening
functionalities
application
prospects
In
particular,
multiple
toughening
mechanisms
were
introduced
at
micro,
nano,
molecular‐level
structures
Additionally,
existing
summarized.
This
aims
offer
significant
guidance
development
inspire
further
research
field
high‐performance
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(3)
Опубликована: Ноя. 3, 2023
Hydrogels
are
considered
as
a
promising
medical
patch
for
wound
healing.
Researches
in
this
aspect
focused
on
improving
their
compositions
and
permeability
to
enhance
the
effectiveness
of
Here,
novel
prolamins-assembled
porous
hydrogel
microfibers
with
desired
merits
treating
diabetes
wounds
presented.
Such
continuously
generated
by
one-step
microfluidic
spinning
technology
acetic
acid
solution
prolamins
continuous
phase
deionized
water
dispersed
phase.
By
adjusting
prolamin
concentration
flow
rates
microfluidics,
structure
morphology
well
diameters
can
be
tailored.
Owing
porosity,
resultant
employed
flexible
delivery
systems
healing
actives,
such
bacitracin
vascular
endothelial
growth
factor
(VEGF).
It
is
demonstrated
that
good
cell-affinity
effective
drug
release
efficiency,
woven
patches
display
superior
vivo
capability
wounds.
Thus,
it
believed
proposed
will
show
important
values
clinic
treatments.
