Trends in Food Science & Technology, Год журнала: 2024, Номер 151, С. 104651 - 104651
Опубликована: Июль 27, 2024
Язык: Английский
Advanced Science, Год журнала: 2023, Номер 10(26)
Опубликована: Июль 5, 2023
Abstract Antimicrobial peptides (AMPs) are essential elements of thehost defense system. Characterized by heterogenous structures and broad‐spectrumaction, they promising candidates for combating multidrug resistance. Thecombined use AMPs with other antimicrobial agents provides a new arsenal ofdrugs synergistic action, thereby overcoming the drawback monotherapiesduring infections. kill microbes via pore formation, thus inhibitingintracellular functions. This mechanism action is an advantage overantibiotics as it hinders development drug The synergisticeffect will allow repurposing conventional antimicrobials andenhance their clinical outcomes, reduce toxicity, and, most significantly,prevent In this review, various synergies ofAMPs miscellaneous discussed. effect ofstructural diversity chemical modification on AMP properties firstaddressed then different combinations that can lead to action,whether combination between antimicrobials, or andmiscellaneous compounds, attended. review serve guidance whenredesigning in antimicrobialagents enhanced outcomes.
Язык: Английский
Процитировано
86
Trends in Microbiology, Год журнала: 2023, Номер 32(4), С. 365 - 378
Опубликована: Ноя. 25, 2023
Язык: Английский
Процитировано
68
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Июль 31, 2024
Antibiotic resistance is a growing global problem that requires innovative therapeutic approaches and strategies for administering antibiotics. One promising approach combination therapy, in which two or more drugs are combined to combat an infection. Along this line, the of antimicrobial peptides (AMPs) with conventional antibiotics has gained attention mainly due complementary mechanisms action AMPs In article, we review both
Язык: Английский
Процитировано
30
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
The emergence of multidrug-resistant (MDR) pathogens, coupled with the limited effectiveness existing antibiotics in eradicating biofilms, presents a significant threat to global health care. This critical situation underscores urgent need for discovery and development antimicrobial agents. Recently, peptide-derived nanomaterials have shown promise combating such infections. Amino acid noncovalent forces, notably π–π stacking electrostatic interactions, remain underutilized guiding coassembly peptides into bacteriostatic nanomaterials. Thus, we constructed dimeric nanopeptide system using disulfide bonds cysteine. self-assembly nanofibers was realized by interaction aromatic amino acids (Trp, Phe, Pyr) attraction between oppositely charged (Asp Arg). optimal peptide 2D2W exhibits potent antibacterial activity against resistant bacteria is nontoxic. Mechanistically, penetrated outer membrane after adsorption, resulting plasma depolarization, homeostatic disruption, ultimately bacterial death. In mouse model peritonitis, demonstrated efficacy vivo treatment conclusion, design nanopeptides co-driven intermolecular forces provides promising avenue high-performance These advances may also facilitate application advancement peptide-based agents clinical practice.
Язык: Английский
Процитировано
4
ACS Nano, Год журнала: 2025, Номер 19(5), С. 5253 - 5268
Опубликована: Янв. 31, 2025
Methicillin-resistant Staphylococcus aureus (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn2+ vancomycin (Van) codelivered nanotherapeutic (named Man-Zn2+/Van NPs) was fabricated characterized via mannose (Man) modification. NPs exhibit significant inhibitory activity against extra- MRSA obviously decrease minimum concentration Van. can be easily internalized by MRSA-infected macrophages significantly accumulated in infected bone Man-mediated targeting. In vivo experiments mouse OM model verified that reduce burden, improve gait patterns, mass, inflammatory cytokine expression. The antibacterial mechanism includes destruction membrane, degeneration proteins DNA, inhibition glycolysis, intervention energy metabolism bacteria. Overall, this metal-antibiotic nanotherapeutics strategy provides new insight for combating infections caused MRSA-induced OM.
Язык: Английский
Процитировано
3
Antibiotics, Год журнала: 2025, Номер 14(3), С. 221 - 221
Опубликована: Фев. 21, 2025
Background/Objectives: Antimicrobial resistance poses a major public health challenge. The World Health Organization has identified 15 priority pathogens that require prompt development of new antibiotics. This review systematically evaluates the antibacterial most significant bacterial pathogens, currently available treatment options, as well complementary approaches for management infections caused by challenging multidrug-resistant (MDR) bacteria. For carbapenem-resistant Gram-negative bacteria, options include combinations beta-lactam antibiotics and beta-lactamase inhibitors, novel siderophore cephalosporin, known cefiderocol, older like polymixins tigecycline. Treatment Gram-positive bacteria are vancomycin, daptomycin, linezolid, etc. Although stagnated, various agents with properties in clinical preclinical trials. Non-antibiotic strategies encompass antibiotic potentiators, bacteriophage therapy, antivirulence therapeutics, antimicrobial peptides, nanomaterials, host-directed vaccines, antibodies, plant-based products, repurposed drugs, their combinations, including those used alongside Significant challenges exist developing antimicrobials, particularly related to scientific technical issues, along policy economic factors. Currently, alternative not part routine protocols. Conclusions Future Directions: There is an urgent need expedite treating MDR requires multidisciplinary approach involves collaboration across research, healthcare, regulatory bodies. Suggested crucial addressing this challenge should be backed rational use, enhanced infection control practices, improved surveillance systems emerging pathogens.
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15493 - 15493
Опубликована: Окт. 23, 2023
Bacterial antibiotic resistance, especially the emergence of multidrug-resistant (MDR) strains, urgently requires development effective treatment strategies. It is always interest to delve into mechanisms resistance current antibiotics and target them promote efficacy existing antibiotics. In recent years, non-antibiotic compounds have played an important auxiliary role in improving promoting drug-resistant bacteria. The combination with considered a promising strategy against MDR this review, we first briefly summarize main addition, propose several strategies enhance action based on mechanisms. Then, research progress that can antibiotic-resistant bacteria through different years also summarized. Finally, prospects challenges these are discussed.
Язык: Английский
Процитировано
30
LWT, Год журнала: 2024, Номер 199, С. 116084 - 116084
Опубликована: Апрель 18, 2024
Listeria monocytogenes is a common foodborne pathogen causing severe listeriosis, with mortality rate of 20-30%. This spreads through biofilm formation in the food industry. Antimicrobial peptides are widely used preservation to combat harmful pathogens. Thanatin, 21-amino acid peptide from Podisus maculiventris, combats various pathogens effectively. study aimed evaluate antimicrobial efficacy thanatin against L. ATCC 19115. The minimum inhibitory concentration (MIC) was determined be 17 μg/mL. Analysis using scanning electron microscope (SEM) confirmed its antibacterial efficacy. Thanatin treatment inhibited swimming motility, formation, auto-aggregation, cytotoxicity, hemolysin activity, adhesion, and host cell invasion by monocytogenes. Concentrations ranging 1/16MIC (27%) MIC (92%) effectively prevented existing biofilms experienced significant reduction (9.41% 80.66%) after treatment. Moreover, exhibited cytotoxic effects on Caco-2 cancer cells (IC50=27.04 μg/mL) decreased hemolytic activity (2.66% 7.33%). Additionally, suppressed expression virulence genes monocytogenes, decreasing pathogenicity. In summary, exhibits beneficial effects, suggesting potential as natural bacteriostatic agent for further research practical implementation.
Язык: Английский
Процитировано
13
ACS Nano, Год журнала: 2024, Номер 18(28), С. 18379 - 18392
Опубликована: Июль 2, 2024
Chronic wound rescue is critical for diabetic patients but challenging to achieve with a specific and long-term strategy. The prolonged bacterial inflammation particularly prevalent in hyperglycemia-induced wounds, usually leading severe tissue damage. Such trend could further suffer from an environmental suitability provided by macrophages persisting Staphylococcus aureus (S. aureus) even deteriorate their mutual reinforcement. However, the strategy of both suppressing bacteria growth immunoreprogramming inflammatory type break vicious harm healing still lacking. Here, self-adapting biomass carboxymethyl chitosan (CMC) hydrogel comprising immunomodulatory nanoparticles reported Gram-negative/Gram-positive elimination anti-inflammatory cytokines induction ameliorate cutaneous microenvironment. Mechanistically, antibacterial peptides CMCs synergistically result inhibition against methicillin-resistant S. (MRSA) over period 7 days, miR-301a reprograms M2 macrophage via PTEN/PI3Kγ/mTOR signaling pathway, consequently mitigating promoting angiogenesis rats. In this vein, immunoregulatory promising all-biomass dressing ensuring biocompatibility, providing perspective regenerate damaged tissue, repairing chronic wounds on skin.
Язык: Английский
Процитировано
12
Materials Horizons, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Infection is the most prevalent complication of fractures, particularly in open and often leads to severe consequences.
Язык: Английский
Процитировано
11