Dalton Transactions,
Год журнала:
2023,
Номер
53(8), С. 3434 - 3444
Опубликована: Дек. 29, 2023
Bacterial
infections
can
lead
to
the
development
of
large-scale
outbreaks
diseases
that
pose
a
serious
threat
human
life
and
health.
Also,
conventional
antibiotics
are
prone
producing
resistance
allergic
reactions,
their
therapeutic
effect
is
dramatically
diminished
when
bacterial
communities
form
biofilms.
Fortunately,
well-designed
supramolecular
coordination
complexes
(SCCs)
have
been
used
as
antibacterials
or
anti-biofilms
in
recent
years.
SCCs
kill
bacteria
by
directly
engaging
with
surface
through
electrostatic
interactions
penetrating
membrane
auxiliary
cell-penetrating
peptides.
Furthermore,
scientists
engineered
fluorescent
produce
reactive
oxygen
species
(ROS)
eliminate
exposed
laser
irradiation,
they
also
demonstrate
outstanding
performance
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(3), С. 1167 - 1315
Опубликована: Янв. 1, 2024
Silicon-based
biomaterials
have
been
extensively
developed
in
the
past
decades.
The
classification,
characteristics,
multi-dimensional
design,
and
biomedical
applications
of
silicon-containing
are
comprehensively
elaborated.
Abstract
Advanced
functional
two‐dimensional
(2D)
nanomaterials
offer
unique
advantages
in
drug
delivery
systems
for
disease
treatment.
Kaolinite
(Kaol),
a
nanoclay
mineral,
is
natural
2D
nanomaterial
because
of
its
layered
silicate
structure
with
nanoscale
layer
spacing.
Recently,
Kaol
used
as
carrier
controlled
release
and
improved
dissolution
owing
to
advantageous
properties
such
surface
charge,
strong
biocompatibility,
naturally
structure,
making
it
an
essential
development
direction
nanoclay‐based
carriers.
This
review
outlines
the
main
physicochemical
characteristics
modification
methods
application
biomedicine.
The
safety
biocompatibility
are
addressed,
details
antibacterial,
anti‐inflammatory,
anticancer
treatment
discussed.
Furthermore,
challenges
prospects
Kaol‐based
biomedicine
recommends
directions
further
nanocarriers
by
improving
their
expanding
bioapplication
range
Kaol.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(45)
Опубликована: Май 28, 2024
Abstract
Reactive
oxygen
species
(ROS)
releasing
materials
are
increasingly
used
in
nanomedicines
due
to
their
effectiveness
against
a
broad
spectrum
of
microbes.
However,
most
ROS‐releasing
rely
on
external
stimuli
such
as
photoirradiation,
either
through
photodynamic
or
photocatalytic
processes,
which
limits
practical
applications.
Herein,
this
work
presents
novel
nanoclay
mediated
self‐promoted
ROS
material
called
vacancies‐rich
ZnO/kaolinite
(O
v
‐rich
ZnO/Kaol).
Both
experiments
and
density
functional
theory
(DFT)
calculations
reveal
that
the
introduction
kaolinite
increases
content
O
ZnO,
change
electronic
structure
promotes
process
adsorption
activation,
resulting
generation
·
2
−
reduction
without
photoirradiation.
Molecular
dynamics
simulations
confirm
enhances
interaction
between
bacterial
membrane,
promoting
bacterial‐killing
effect
.
More
importantly,
ZnO/Kaol
is
successfully
prepared
pilot
scale
manufacture
antibacterial
gauze,
showed
at
least
99%
activity
both
Escherichia
coli
(
E.
)
Staphylococcus
aureus
S.
absence
light.
The
as‐prepared
also
exhibited
satisfactory
biocompatibility
biosafety.
This
method
can
offer
more
benign
approach
address
limitations
traditional
photoirradiation‐dependent
photosensitizers
for
antimicrobial
gauze.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(3)
Опубликована: Май 1, 2024
Abstract
Natural
bioactive
compounds
from
plants
exhibit
substantial
pharmacological
potency
and
therapeutic
value.
However,
the
development
of
most
plant
is
hindered
by
low
solubility
instability.
Conventional
pharmaceutical
forms,
such
as
tablets
capsules,
only
partially
overcome
these
limitations,
restricting
their
efficacy.
With
recent
nanotechnology,
nanocarriers
can
enhance
bioavailability,
stability,
precise
intracellular
transport
compounds.
Researchers
are
increasingly
integrating
nanocarrier‐based
drug
delivery
systems
(NDDS)
into
natural
with
significant
success.
Moreover,
products
benefit
nanotechnological
enhancement
contribute
to
innovation
optimization
via
self‐assembly,
grafting
modifications,
biomimetic
designs.
This
review
aims
elucidate
collaborative
reciprocal
advancement
achieved
botanical
products,
compounds,
polysaccharides,
proteins,
extracellular
vesicles.
underscores
salient
challenges
in
nanomedicine,
encompassing
long‐term
safety
evaluations
nanomedicine
formulations,
targeting
mechanisms,
biodistribution
complexities,
hurdles
clinical
translation.
Further,
this
study
provides
new
perspectives
leverage
nanotechnology
promoting
for
nanomedical
applications
guiding
progression
NDDS
toward
enhanced
efficiency,
precision,
safety.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanotechnology
Biology
Nanoscale
Systems
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10377 - 10377
Опубликована: Сен. 26, 2024
Polymers
of
natural
origin,
such
as
representatives
various
polysaccharides
(e.g.,
cellulose,
dextran,
hyaluronic
acid,
gellan
gum,
etc.),
and
their
derivatives,
have
a
long
tradition
in
biomedical
applications.
Among
them,
the
use
chitosan
safe,
biocompatible,
environmentally
friendly
heteropolysaccharide
has
been
particularly
intensively
researched
over
last
two
decades.
The
potential
using
for
medical
purposes
is
reflected
its
unique
cationic
nature,
viscosity-increasing
gel-forming
ability,
non-toxicity
living
cells,
antimicrobial
activity,
mucoadhesiveness,
biodegradability,
well
possibility
chemical
modification.
intuitive
clay
minerals
treatment
superficial
wounds
known
traditional
medicine
thousands
years.
To
improve
efficacy
overcome
ubiquitous
bacterial
resistance,
beneficial
properties
utilized
preparation
chitosan–clay
mineral
bionanocomposites.
focus
this
review
on
composites
containing
with
montmorillonite
halloysite
minerals.
This
highlights
antibacterial
bionanocomposites
drug
delivery
topical
skin
infections
wound
healing.
Finally,
an
overview
preparation,
characterization,
possible
future
perspectives
related
to
these
advancing
applications
presented.
Ceramics International,
Год журнала:
2023,
Номер
50(1), С. 1329 - 1340
Опубликована: Окт. 29, 2023
The
specific
behaviour
of
kaolinites
heated
between
600
and
800
°C
(metakaolinite)
makes
this
material
very
appropriate
to
be
used
as:
i)
ecological
pozzolanic
additive
ordinary
Portland
cement
(OPC),
ii)
precursor
geopolymers,
iii)
carrier/supplier
metal
nanoparticles
with
bactericidal/virucidal
activity,
iv)
catalytic
reactions.
strong
reactivity
the
metakaolinite
(mixed
2SiO2.Al2O3
oxide)
is
mainly
associated
presence
a
large
fraction
(>50
%)
five-coordinated
aluminum
in
its
disordered
structure.
thermal
treatment
favours
formation
stable
mullite
below
1250
°C.
alkaline
activation
produces
geopolymers
remarkable
mechanical
properties,
which
reduce
CO2
emission
OPC
manufacture.
This
metakaolinite-derived
also
permit
homogeneous
safe
stockage
contaminants
radioactive
Cs
Sr
cations.
Finally,
retention
Ag
Cu
at
metakaolin
surface
has
been
successfully
as
support
well
dispenser
antimicrobial/virucidal
agents.
fact
opens
possibility
use
for
another
kind
nanoparticle
(i.e.
Pt,
Rd,
Au,
Pd,
etc)
applications
health.
critical
review
provides
an
overview
importance
structure
main
applications.
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 27, 2024
In
construction
engineering,
there
is
currently
a
strong
emphasis
on
finding
materials,
mainly
the
binder
which
plays
crucial
role,
that
meet
multiple
criteria,
including
sustainability,
cost-effectiveness,
durability,
and
reduced
environmental
impact.
However,
growing
interest
in
exploring
alternatives
to
traditional
binders
address
limitations
associated
with
their
production
use.
One
such
alternative
use
of
naturally
occurring
materials
like
clay.
Clay
deposits
are
abundant
widely
available,
making
them
sustainable
resource
for
applications.
Moreover,
clay
contains
significant
amounts
silica
alumina,
key
components
inducing
pozzolanic
reactions
contribute
strength
durability
concrete.
recent
studies,
nanoclays
(NCs)
have
emerged
as
promising
addition
supplementary
cementitious
materials.
These
nanoparticles
possess
unique
properties
can
enhance
performance
Nanoclays
significantly
improve
compressive
strength,
concrete
structures.
The
high
surface
area
reactivity
facilitate
better
bonding
between
cement
particles,
resulting
enhanced
mechanical
properties.
This
chapter
aims
discuss
state
art
enhancements
building
employ
different
types
place
conventional
future
trends.
