Microbiological Research, Год журнала: 2024, Номер 292, С. 127987 - 127987
Опубликована: Ноя. 30, 2024
Язык: Английский
Angewandte Chemie International Edition, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2024, Номер 11(22)
Опубликована: Март 15, 2024
In the treatment of refractory corneal ulcers caused by Pseudomonas aeruginosa, antibacterial drugs delivery faces drawbacks low permeability and short ocular surface retention time. Hence, novel positively-charged modular nanoparticles (NPs) are developed to load tobramycin (TOB) through a one-step self-assembly method based on metal-phenolic network Schiff base reaction using 3,4,5-trihydroxybenzaldehyde (THBA), ε-poly-ʟ-lysine (EPL), Cu
Язык: Английский
Процитировано
10
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Ocular injury and infection are significant causes of vision impairment blindness globally. Effective treatment is, however, challenging due to the physical barrier cornea, which restricts drug penetration in eye, as well presence eye that necessitates continuous delivery growth factors on ocular surface for cornea healing. Here, we introduce a transformative wearable corneal microneedle (MN) patch designed efficient therapy infection. The MN comprises water-soluble tips encapsulate antibacterial nanoparticles (NPs), along with backing layer contains epidermal factor (EGF). Upon insertion into dissolve swiftly within stroma, resulting release antimicrobial NPs efficiently eradicate bacteria. Meanwhile, residual undergoes rapid situ transformation upon contact mildly acidic fluid from infected edema, converting lens conforms eye's surface, facilitates sustained EGF over 8 h promote Benefiting these features, demonstrates superior efficacy treating injuries infections vivo, offering promising therapeutic strategy manage diseases.
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2024, Номер 11(39)
Опубликована: Июль 15, 2024
Abstract Growing demand for wound care resulting from the increasing chronic diseases and trauma brings intense pressure to global medical health service system. Artificial skin provides mechanical microenvironmental support wound, which is crucial in healing tissue regeneration. However, challenges still remain clinical application of artificial since lack synergy effect necessary performance. In this study, a multi‐functional fabricated through microfluidic spinning technology by using core‐shell gel nanofiber scaffolds (NFSs). This strategy can precisely manipulate microstructure under microscale. The as‐prepared demonstrates superior characteristics including surface wettability, breathability, high strength, strain sensitivity, biocompatibility biodegradability. Notably, has capability deliver medications controlled sustained manner, thereby accelerating process. innovative approach paves way development new generation introduces novel concept structural design unique NFSs.
Язык: Английский
Процитировано
7
Angewandte Chemie, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 309, С. 142893 - 142893
Опубликована: Апрель 9, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2024, Номер 30, С. 101400 - 101400
Опубликована: Дек. 12, 2024
Язык: Английский
Процитировано
2
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(44), С. 59880 - 59894
Опубликована: Окт. 22, 2024
Posterior capsular opacification (PCO) is a common complication following cataract surgery, which can lead to significant vision loss. This study introduces facile method for developing metformin-derived hydrogel (HCM6) stabilized by dynamic covalent bonds among natural polymers. demonstrates antifibrotic properties, on-demand drug release, pH responsiveness, injectability, and self-healing capabilities. Our in vitro experiments confirmed that the HCM6 exhibits excellent biocompatibility, inhibiting lens epithelial cell migration, transforming growth factor-2β (TGFβ2)-induced α-smooth muscle actin (α-SMA) expression cells. In vivo studies conducted rat extracapsular extraction (ECLE) model revealed significantly suppressed PCO after 21 days of implantation with no observed pathological effects on surrounding tissues or optic nerve. According our experimental results, inhibitory mechanism may be attributed metformin's suppressive effect epithelial–mesenchymal transition (EMT), fiber formation. summary, long-acting, controllable, release characteristics not only provide an effective strategy preventing but also offer new avenues treating undesirable proliferative conditions ophthalmology beyond.
Язык: Английский
Процитировано
1
Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Free radical therapy, based on the sulfate derived from peroxymonosulfate, has recently been explored as a potential cancer treatment. However, while it is promising, its successful application restricted by several limitations including uncontrollable generation of free radicals and instability in aqueous medium. Herein, we prepared LCP nanoparticles using PMS core, Co-coordination polymer (Co-CP) coating layer, lactobionic acid targeting ligand for hepatoma carcinoma cells. could be activated cobalt ions released Co-CP, successfully induced apoptosis ferroptosis
Язык: Английский
Процитировано
1
Microbiological Research, Год журнала: 2024, Номер 292, С. 127987 - 127987
Опубликована: Ноя. 30, 2024
Язык: Английский
Процитировано
0