Core‐Shell Gel Nanofiber Scaffolds Constructed by Microfluidic Spinning toward Wound Repair and Tissue Regeneration
Advanced Science,
Год журнала:
2024,
Номер
11(39)
Опубликована: Июль 15, 2024
Abstract
Growing
demand
for
wound
care
resulting
from
the
increasing
chronic
diseases
and
trauma
brings
intense
pressure
to
global
medical
health
service
system.
Artificial
skin
provides
mechanical
microenvironmental
support
wound,
which
is
crucial
in
healing
tissue
regeneration.
However,
challenges
still
remain
clinical
application
of
artificial
since
lack
synergy
effect
necessary
performance.
In
this
study,
a
multi‐functional
fabricated
through
microfluidic
spinning
technology
by
using
core‐shell
gel
nanofiber
scaffolds
(NFSs).
This
strategy
can
precisely
manipulate
microstructure
under
microscale.
The
as‐prepared
demonstrates
superior
characteristics
including
surface
wettability,
breathability,
high
strength,
strain
sensitivity,
biocompatibility
biodegradability.
Notably,
has
capability
deliver
medications
controlled
sustained
manner,
thereby
accelerating
process.
innovative
approach
paves
way
development
new
generation
introduces
novel
concept
structural
design
unique
NFSs.
Язык: Английский
Advances in medical devices using nanomaterials and nanotechnology: Innovation and regulatory science
Bioactive Materials,
Год журнала:
2025,
Номер
48, С. 353 - 369
Опубликована: Фев. 20, 2025
Язык: Английский
Functionalized gelatin/poly(l-lactide-co-ε-caprolactone) fibrous membrane promotes scarless wound healing by modulating inflammation and reducing fibrosis
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
306, С. 141785 - 141785
Опубликована: Март 5, 2025
Язык: Английский
Microfluidic Construction of Heterogeneous Micro–Nano-Structured Materials for Biomedical Applications
ACS Materials Letters,
Год журнала:
2025,
Номер
unknown, С. 1462 - 1487
Опубликована: Март 20, 2025
Язык: Английский
A Multifunctional Nanocomplex as miRNA/Antibiotic Co‐Delivery System Based on Tetrahedral Framework DNA: Application to Infected Wound Healing
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 16, 2024
Abstract
Infected
wounds
are
a
complex
disease
involving
bacterial
infections
and
dysregulated
inflammation.
However,
current
research
has
mostly
focused
on
inhibition
rather
than
Thus,
combined
therapeutic
strategies
with
anti‐bacterial
anti‐inflammation
efficacies
urgently
needed.
Antibiotics
the
main
treatment
strategy
for
infections.
excessive
use
of
antibiotics
throughout
body
can
cause
serious
side
effects.
In
addition,
miRNA‐based
therapeutics
superior
wounds,
but
their
rapid
degradation
poor
cellular
uptake
limit
clinical
application.
Tetrahedral
framework
DNA
(tFNA)
is
an
ideal
drug
delivery
system
owing
to
its
excellent
stability
remarkable
transport
ability.
Herein,
novel
multi‐functional
miRNA
antibiotic
co‐delivery
based
tFNA
presented
first
time,
called
B/L.
B/L
heightened
resistance
serum
codelivery
After
transdermal
administration,
specifically
target
TNF
receptor‐associated
factor
6(TRAF6)
IL‐1receptor‐associated
kinase
1(IRAK1),
thereby
regulating
nuclear
kappa‐B
(NF‐𝜿B)
thus
effectively
reducing
inflammation
promoting
healing
infected
wounds.
This
provides
versatile,
simple,
biocompatible,
powerful
platform
personalized
multiple
diseases.
Язык: Английский
Electrical Microneedles for Wound Treatment
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Electrical
stimulation
has
been
hotpot
research
and
provoked
extensive
interest
in
a
broad
application
such
as
wound
closure,
tissue
injury
repair,
nerve
engineering.
In
particular,
immense
efforts
have
dedicated
to
developing
electrical
microneedles,
which
demonstrate
unique
features
terms
of
controllable
drug
release,
real-time
monitoring,
therapy,
thus
greatly
accelerating
the
process
healing.
Here,
review
state-of-art
concerning
microneedles
applied
for
treatment
is
presented.
After
comprehensive
analysis
mechanisms
on
healing,
derived
three
types
are
clarified
summarized.
Further,
their
applications
healing
highlighted.
Finally,
current
perspectives
directions
development
future
improving
addressed.
Язык: Английский
Multifunctional Nanofiber Membranes Constructed by Microfluidic Blow-Spinning to Inhibit Scar Formation at Early Intervention Stage
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(39), С. 53042 - 53059
Опубликована: Сен. 19, 2024
Pathological
scarring
has
been
a
challenge
in
skin
injury
repair
since
ancient
times,
and
prophylactic
treatment
the
early
stages
of
wound
healing
usually
results
delayed
healing.
In
this
study,
poly(ethylene
oxide)
(PEO)
chitosan
(CTS)
were
used
as
carrier
materials
to
construct
multifunctional
pirfenidone
(PFD)/CTS/PEO
(PCP)
nanofiber
membranes
(NFMs)
loaded
with
PFD
by
microfluidic
blow-spinning
(MBS).
MBS
is
good
method
for
quickly,
safely,
greenly
constructing
large-area
manufacturing
inexpensive
NFMs.
PCP
NFMs
uniform
external
morphology,
diameters
ranging
from
200
500
nm.
The
encapsulation
efficiency
drug-loaded
was
above
80%,
which
had
slow
release,
visualization,
water
absorption,
biocompatibility.
inhibitory
effect
on
normal
human
dermal
fibroblasts
dose-dependent
inhibited
expression
transforming
growth
factor-β1/SMAD
family
member
3
(TGF-β1/SMAD3)
signaling
pathway.
showed
significant
antibacterial
effects
against
both
Язык: Английский