Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

Advanced Materials, Год журнала: 2024, Номер 36(27)

Опубликована: Март 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Язык: Английский

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A Renal Clearable Nano‐Assembly with Förster Resonance Energy Transfer Amplified Superoxide Radical and Heat Generation to Overcome Hypoxia Resistance in Phototherapeutics

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(44)

Опубликована: Июнь 28, 2024

Abstract Given that type I photosensitizers (PSs) possess a good hypoxic tolerance, developing an innovative tactic to construct PSs is crucially important, but remains challenge. Herein, we present smart molecular design strategy based on the Förster resonance energy transfer (FRET) mechanism develop photodynamic therapy (PDT) agent with encouraging amplification effect for accurate tumor therapy. Of note, benefiting from FRET effect, obtained nanostructured PDT (NanoPcSZ) boosted light‐harvesting ability not only amplifies superoxide radical (O 2 •‐ ) production also promotes heat generation upon near‐infrared light irradiation. These features facilitate NanoPcSZ realize excellent phototherapeutic response under both normal and environments. As result, in vitro vivo experiments achieved remarkable improvement therapeutic efficacy via combined of photothermal action photoreaction. Notably, can be eliminated organs (including liver, lung, spleen, kidney) apart site excreted through urine within 24 h its systemic administration. In this way, potential biotoxicity drug accumulation avoided biosafety further enhanced.

Язык: Английский

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Effective One‐for‐All Phototheranostic Agent for Hypoxia‐Tolerant NIR‐II Fluorescent/PA Image‐Guided Phototherapy

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Near-infrared (NIR)-triggered type-I photosensitizers are crucial to address the constraints of hypoxic tumor microenvironments in phototherapy; however, significant challenges remain. By selecting an electron-deficient unit, a matched energy gap upper-level state is instrumental boosting efficiency intersystem crossing for electron transfer process. 2-Cyanothiazole, acceptor, covalently linked with N, N-diphenyl-4-(thiophen-2-yl)aniline yield multifunctional photosensitizer (TTNH) that exhibits intrinsic NIR absorbance and compatible T2 levels, facilitating both radiative nonradiative transitions. The prepared nanoparticles (TTNH NPs) assembled from TTNH activated by 808 nm laser generated O2•- hypoxia-tolerant photodynamic therapy under normoxia conditions. NPs emitted NIR-II fluorescence impressive quantum 2.08%. With high photothermal conversion 51.8% stimulation, exhibit performance, accompanied enhanced photoacoustic imaging capability owing their strong absorption. These characteristics make effective NIR-wavelength-triggered phototheranostic agent outperforms fluorescence/photoacoustic dual-model imaging-guided therapy/photothermal against tumors. This results provide valuable insight developing high-performance NIR-II-emissive superoxide radical agents.

Язык: Английский

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Integrin‐Targeted, Activatable Nanophototherapeutics for Immune Modulation: Enhancing Photoimmunotherapy Efficacy in Prostate Cancer Through Macrophage Reprogramming

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

ABSTRACT Prostate cancer is an epithelial malignancy with a high incidence among elderly men. Photochemistry‐based dye photodrugs (known as photosensitizers) offer promising clinical approach for treating tumors. These agents work by inducing immunogenic cell death (ICD), which activates antitumor immune response. This favored owing to its minimal invasiveness, low toxicity, and efficiency. However, the immunosuppressive microenvironment of characteristics “cold” tumors significantly restricts efficacy photodrugs. Developing advanced nanocarrier system deliver agonists efficient drug delivery tumor lesion sites reshape crucial in practice. Therefore, this study, we designed integrin‐targeted, activatable nano photodrug co‐assembly agonist (RPST@IMQ) enhancing photoimmunotherapy prostate via reprogramming tumor‐associated macrophages. The active‐targeted nanosystem enhanced dosage at site through systemic administration. High doses glutathione cleaved disulfide bonds RPST@IMQ, releasing imiquimod (IMQ). Under photoirradiation, generated significant singlet oxygen eliminate cells, thereby ICD activate responses. Simultaneously, released IMQ reprograms M2‐type macrophages (TAMs) into M1‐type TAMs tumor‐killing capabilities, converting “hot” conversion enhances therapeutic against primary distant vivo. study offers new insights development innovative, smart, enhance anticancer outcomes.

Язык: Английский

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A Smart Visualized Phototherapy Switch: From NIR‐I Imaging‐Guided Photodynamic Therapy to NIR‐II‐Guided Photothermal Therapy for Enhanced Cascade Tumor Photoablation

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

ABSTRACT Imaging‐guided phototherapy holds promise for precision cancer treatment. However, most photosensitizers have only a singular modality of photodynamic therapy (PDT) or photothermal (PTT), which make their therapeutic efficacy severely limited by the hypoxic and complex tumor microenvironment (TME). In this article, we provide smart platform design (BOD‐D) based on visualized light‐triggered phototherapeutic switch transforming from near‐infrared (NIR)‐I imaging‐guided PDT to activatable NIR‐II‐guided PTT while releasing nitric oxide (NO) gas (GT). BOD‐D releases native NIR one‐region fluorescence signals in tumors, is used direct robust killing. As administered, decreasing oxygen content TME becomes progressively insufficient maintain its excellent cell‐killing effect. Subsequently, light triggers dissociation NO BOD‐D, activating agent BOD‐T that emits NIR‐II fluorescence, subsequent PTT. Notably, not light‐mediated mechanism can be switched NIR‐I‐guided PTT, but also released during process will GT sensitize above Our study contributes intelligent cascade photoablation.

Язык: Английский

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Supramolecular Synthesis of Dithienylethene‐Albumin Complexes for Enhanced Photoswitching In Photoacoustic Imaging‐Guided Near‐Infrared Photothermal Therapy

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Abstract Photoswitchable molecules can transit between two distinct isomers, enabling them to perform highly controllable imaging and therapeutic functions under certain laser irradiation. Dithienylethenes (DTEs), a class of photoswitchable molecules, exhibit strong thermal stability high fluorescence quantum yield. However, the short excitation wavelength poses significant challenge for application DTEs in photocontrolled therapy. Therefore, development DTE‐based derivatives or hybrid materials with near‐infrared (NIR) is great importance. In this study, novel DTE are synthesized, whose closed‐ring isomers absorption NIR region. Compared derivative previously reported commercially available ones, these show higher photoswitching efficiency extended wavelength. Notably, supramolecular assembly albumin confers NIR‐activated photothermal switching ability on aqueous solution. addition, DTE‐albumin nanoparticles further developed enable photoacoustic (PAI) therapy (PTT) vivo antitumor applications. Finally, by integrating thermo‐responsive free radical initiator into nanoparticles, PTT chemodynamic (CDT) achieved, effectively inhibiting tumor growth preventing metastasis.

Язык: Английский

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Win–Win Integration of Genetically Engineered Cellular Nanovesicles with High‐Absorbing Multimodal Phototheranostic Molecules for Boosted Cancer Photo‐Immunotherapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Photo-immunotherapy is one of the most promising cancer treatment strategies. As immunotherapeutic agents, immune checkpoint blockade antibodies against programmed cell death protein 1 (PD-1) or ligand (PD-L1) exhibit substantial potential, but have to face non-specific distribution and subsequent immune-related adverse events. Meanwhile, high-performance phototheranostic agents concurrently possessing multiple modalities high light-harvesting capacity are really attractive highly desired as touching modules. Herein, a win-win strategy that integrates molecule design targeted module preparation developed construct high-powered photo-immunotherapy systems. Specifically, agent (AOTTIT) displaying typical aggregation-induced fluorescence extending second near-infrared II window, well outstanding reactive oxygen species heat production first obtained via ingenious design. Notably, AOTTIT exhibits record molar extinction coefficient among reported organic multimodal molecules. PD-1 genetically engineered membrane-derived nanovesicles (PD-1/CMNVs) prepared both nanocarriers camouflage nanoparticles, yielding multifunctional photo-immunotherapeutic (CMNPs/PD-1) with tumor-specific active homologous targeting ability. The distinct suppression primary metastatic lung tumors after only once tumor substantiated synergistically strengthened efficiency this strategy.

Язык: Английский

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Responsive Theranostic Nanoprobe for Ratiometric Photoacoustic Monitoring of Hypochlorous Acid‐Mediated Inflammation in Cancer Photothermal Therapy

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

Abstract Cancer detection and inflammation monitoring during photothermal therapy (PTT) enable timely cancer intervention precise control, advancing to address inflammation‐related tumor recurrence metastasis associated with PTT. This can be achieved through real‐time biomarker for inflammation, like hypochlorous acid (HOCl), a highly reactive oxygen species (hROS) in body elevated levels inflammation. Here, HOCl‐responsive theranostic nanoprobe is introduced, AuNRs@SiO 2 ‐CAA ratiometric photoacoustic (PA) emits PA signals at 680 820 nm, only PA680 undergoing changes the presence of HOCl, enabling HOCl imaging via recording (PA680/PA820). exhibits high selectivity sensitivity, limit 0.34 µM HOCl. In vivo, it effectively detects tumor, drives PTT, monitors PTT by sensing The successful development offers novel system diagnosis, poised enhance control.

Язык: Английский

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Microtubule polymerization induced by iridium‐fullerene photosensitizers for cancer immunotherapy via dual‐reactive oxygen species regulation strategy

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Июнь 25, 2024

Abstract Microtubules (MTs) are key players in cell division, migration, and signaling, they regarded as important targets for cancer treatment. In this work, two fullerene (C 60 )‐functionalized Ir(III) complexes ( Ir‐C 1 2 ) rationally designed dual reactive oxygen species (ROS) regulators MT‐targeted Type I/II photosensitizers. the dark, Ir ‐C serve ROS scavengers to eliminate O • − •OH, consequently reducing dark cytotoxicity reversing dysfunctional T cells. Due efficiently populated C ‐localized intraligand triplet state, I r can be excited by green light (525 nm) produce •OONO (Type I) II) overcome tumor hypoxia. Moreover, is also able photooxidize tubulin, interfering with cellular cytoskeleton structures, inducing immunogenic death inhibiting proliferation migration. Finally, exhibits promising photo‐immunotherapeutic effects both vitro vivo. all, we report here first MT stabilizing photosensitizer performing through photodynamic therapy pathways, which provides insights into rational design of new agents targeting specific biomolecules.

Язык: Английский

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Copper‐infused zinc porphyrin supramolecular polymersomes for triple synergistic combat against wound bacterial biofilm infections

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Окт. 15, 2024

Abstract Bacterial biofilm infections (BBI) on wound surfaces and implants pose a significant clinical challenge due to the impermeable nature of biofilms obstacles in tissue repair. Traditional photothermal therapy (PTT) or chemodynamic (CDT), whether used alone combination, often causes damage surrounding normal tissues from high operating temperatures elevated levels reactive oxygen species, leading unsatisfactory anti‐biofilm effects. This study introduces novel copper ions loaded zinc porphyrin polymer vesicle (Cu‐PPS) that employs triple synergistic approach involving PTT, CDT, bacterial cuproptosis‐like death (BCD). Cu‐PPS exhibits exceptional efficiency 51.06%, promoting release under stimulation, enhancing CDT BCD effectiveness, facilitating mature clearance achieves bactericidal rate exceeding 99% an 93.32% vitro also excellent efficacy treating BBI vivo. presents innovative therapeutic strategy for combating infections, addressing challenges encountered management BBI.

Язык: Английский

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