Gerontology,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Ноя. 6, 2024
Introduction:
Physical
function
and
cognition
seem
to
be
interrelated,
especially
in
the
oldest-old.
However,
temporal
order
which
they
are
related
role
of
brain
health
remain
uncertain.
Methods:
We
included
338
participants
(mean
age
93.1
years)
from
two
longitudinal
cohorts:
UCI
90+
Study
EMIF-AD
Study.
tested
association
between
physical
(Short
Performance
Battery,
gait
speed,
handgrip
strength)
at
baseline
with
cognitive
decline
(MMSE,
memory
tests,
animal
fluency,
Trail
Making
Test
(TMT-)
A,
digit
span
backward)
follow-up
3.3
years).
also
whether
measures
for
(hippocampal,
white
matter
lesion,
gray
volume)
were
was
a
common
driver
by
adding
it
as
confounder
(if
applicable).
Results:
Better
performance
on
all
tests
associated
less
MMSE,
memory,
TMT-A.
Conversely,
fewer
associations
significant,
but
better
scores
TMT-A,
backward
decline.
When
confounder,
stayed
significant
except
speed
Conclusion:
In
oldest-old,
strongly
related,
independently
health.
Also,
is
more
pronounced
than
other
way
around,
suggesting
potential
slowing
optimizing
function.
GeroScience,
Год журнала:
2024,
Номер
46(5), С. 4883 - 4894
Опубликована: Июнь 3, 2024
Experiencing
decline
in
both
cognition
and
mobility
is
associated
with
a
substantially
higher
dementia
risk
than
cognitive
only.
Metabolites
declines
may
be
early
predictors
of
reveal
specific
pathways
to
dementia.
We
analyzed
data
from
2450
participants
initially
free
who
had
613
metabolites
measured
plasma
1998-1999
(mean
age
=
75.2
±
2.9
years
old,
37.8%
Black,
50%
women)
the
Health,
Aging
Body
Composition
study.
Dementia
diagnosis
was
determined
by
race-specific
3MS
scores,
medication
use,
hospital
records
through
2014.
Cognition
were
repeatedly
using
20-m
walking
test
up
10
years,
respectively.
examined
metabolite
associations
changes
(n
2046)
gait
speed
2019)
multivariable
linear
regression
adjusted
for
age,
sex,
race,
baseline
performance
Cox
regression.
During
mean
follow-up
9.3
534
(21.8%)
developed
On
average,
declined
0.47/year
0.04
m/sec/year.
After
covariate
adjustment,
75
decline,
111
(FDR-adjusted
p
<
0.05).
Twenty-six
declines.
Eighteen
26
(p
0.05),
notably
amino
acids,
glycerophospholipids
(lysoPCs,
PCs,
PEs),
sphingolipids.
Results
remained
similar
after
adjusting
cardiovascular
disease
or
apolipoprotein
E
ɛ4
carrier
status.
aging,
metabolomic
profiles
show
distinct
shared
signatures.
Shared
suggest
that
inflammation
deficits
mitochondria
urea
cycle
addition
central
nervous
system
play
key
roles
predict
Future
studies
are
warranted
investigate
longitudinal
markers
pathologies.
Abstract
Background
While
assessment
tools
can
increase
the
detection
of
cognitive
impairment,
there
is
currently
insufficient
evidence
regarding
clinical
outcomes
based
on
screening
for
impairment
in
older
adults.
Methods
The
study
purpose
was
to
investigate
whether
Timed
Up
and
Go
dual-task
test
(TUGdt)
results,
TUG
combined
with
two
different
verbal
tasks
(name
animals,
TUGdt-NA,
recite
months
reverse
order,
TUGdt-MB),
predicted
dementia
incidence
over
a
period
five
years
among
patients
(
N
=
186,
mean
70.7
years;
45.7%
female)
diagnosed
Subjective
Cognitive
Impairment
(SCI)
Mild
(MCI)
following
at
memory
clinics.
Associations
between
parameters
were
examined
Cox
regression
models.
Results
During
follow-up
time
(median
(range)
3.7
(0.1–6.1)
years)
98
participants
converted
dementia.
Novel
findings
indicated
that
TUGdt
parameter
words/time,
after
adjustment
age,
gender,
education,
be
used
prediction
conversion
SCI
or
MCI
years.
Among
TUG-related
investigated,
words/time
showed
best
predictive
capacity,
while
scores
as
well
cost
did
not
produce
significant
results.
further
step
length
during
predicts
before
education.
Optimal
cutoffs
predicting
2-
4-year
calculated.
sensitivity
high
2-year
follow-up:
TUGdt-NA
0.79;
TUGdt-MB
0.71;
reducing
respectively
0.64
0.65
follow-up.
Conclusions
have
potential
cost-efficient
conversion-to-dementia
risk
assessment,
useful
research
purposes.
These
may
able
bridge
gap
such
outcomes.
Trial
registration
ClinicalTrials.gov
Identifier:
NCT05893524:
https://www.clinicaltrials.gov/study/NCT05893524?id=NCT05893524&rank=1
.
The journal of nutrition health & aging,
Год журнала:
2024,
Номер
28(9), С. 100334 - 100334
Опубликована: Авг. 24, 2024
The
aim
of
this
study
was
to
examine
the
longitudinal
relationships
between
trajectories
distinct
subtypes
various
domains
social
supports
and
risk
subjective
motoric
cognitive
(MCR)
syndrome.
Journal of the American Geriatrics Society,
Год журнала:
2024,
Номер
72(11), С. 3437 - 3447
Опубликована: Авг. 29, 2024
Abstract
Background
Gait
performance
can
provide
valuable
insights
into
cognitive
functioning
in
older
adult
and
may
be
used
to
screen
for
impairment.
However,
the
optimal
test
condition
spatiotemporal
parameter
accuracy
have
not
yet
been
determined.
This
study
aims
determine
gait
measure
with
highest
identifying
decline.
Methods
A
total
of
711
participants
were
recruited,
including
332
cognitively
healthy
individuals,
264
mild
impairment
(MCI),
115
dementia,
a
mean
age
72
years
(interquartile
range
69–76),
43%
(
n
=
307)
women.
The
underwent
assessment
three
different
conditions,
single
task
dual
tasks
counting
backward
by
ones
naming
animals.
Results
was
deteriorated
as
progressed.
performed
during
animals
most
accurate
differentiating
between
groups.
Specifically,
speed
more
discriminating
control
from
those
(area
under
curve
[AUC]
76.9%
MCI
99.7%
people
dementia
group
reference).
coefficient
stride
length
variability
while
effective
groups
(AUC
96.7%).
Conclusions
dual‐task
screening
adults,
regardless
their
abilities.
is
useful
clinical
settings
subjects
profiles.
