Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 6891 - 6952

Опубликована: Май 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Язык: Английский

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Self-supported electrocatalysts for the hydrogen evolution reaction

Materials Chemistry Frontiers, Год журнала: 2022, Номер 7(4), С. 567 - 606

Опубликована: Дек. 15, 2022

The high-performance self-supported electrocatalysts for the hydrogen evolution reaction are systematically summarized.

Язык: Английский

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Facile synthesis of 2D Al-TCPP MOF nanosheets for efficient sonodynamic cancer therapy

Materials Chemistry Frontiers, Год журнала: 2023, Номер 7(8), С. 1684 - 1693

Опубликована: Янв. 1, 2023

2D Al-TCPP MOF nanosheets were prepared via a simple solvothermal synthesis method without the need for any surfactants and found to be an effective sonosensitizer sonodynamic cancer therapy.

Язык: Английский

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Size engineering of 2D MOF nanosheets for enhanced photodynamic antimicrobial therapy

Chinese Chemical Letters, Год журнала: 2023, Номер 34(9), С. 108140 - 108140

Опубликована: Янв. 14, 2023

Язык: Английский

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Progress in nanomaterial-based synergistic photothermal-enhanced chemodynamic therapy in combating bacterial infections

Progress in Materials Science, Год журнала: 2024, Номер 144, С. 101292 - 101292

Опубликована: Апрель 6, 2024

The prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a serious threat to clinical treatment and global human health, become one the most important challenges in therapy. Hence, there is an urgent need develop safe, effective, new antibacterial strategies based on multifunctional nanomaterials for accurate detection MDR infections. Chemodynamic therapy (CDT) emerging therapeutic strategy that uses Fenton/Fenton-like metal-based nanocatalysts convert hydrogen peroxide (H2O2) into hydroxyl radicals (OH) destroy Despite enormous potential CDT, single CDT limitations such low catalytic efficacy insufficient production H2O2. In this regard, can be combined with other strategies, photothermal (PTT), which effectively enhanced by PTT heating effect. Thus, rational combination nanoplatform been demonstrated highly efficient achieving better This review summarizes discusses latest advances photothermal-enhanced (PT/CDT) infection theranostics well advantages, challenges, future research directions applications, will inspire development PT/CDT

Язык: Английский

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Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO_2−x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(31)

Опубликована: Сен. 14, 2023

Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover effect, but also stabilize generated vacancies. Meanwhile, provide anchoring sites forming strong metal‐support interactions thus preventing their agglomerations. Importantly, reduced at 350 °C (Pt/CeO ‐350R) exhibits excellent enzyme‐mimicking activity reactive species (e.g., ·OH) compared other control samples, including temperatures, achieving performance tumor‐specific therapy efficiently eliminate cells in vitro ablate tumors vivo. ‐350R originates good activities vacancy‐rich nanoclusters.

Язык: Английский

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All-in-One Engineering Multifunctional Nanoplatforms for Sensitizing Tumor Low-Temperature Photothermal Therapy In Vivo

ACS Nano, Год журнала: 2023, Номер 17(20), С. 20218 - 20236

Опубликована: Окт. 15, 2023

Low-temperature photothermal therapy (PTT) is a noninvasive method that harnesses the effect at low temperatures to selectively eliminate tumor cells, while safeguarding normal tissues, minimizing thermal damage, and enhancing treatment safety. First we evaluated transcriptome of cells gene level following low-temperature observed significant enrichment genes involved in cell cycle heat response-related signaling pathways. To address this challenge, have developed an engineering multifunctional nanoplatform offered all-in-one strategy for efficient sensitization PTT. Specifically, utilized MoS2 nanoparticles as core generate temperature (40–48 °C). The was coated with DPA load CPT-11 Fe2+ further modified PEG iRGD enhance specificity (MoS2/Fe@CPT-11-PEG-iRGD). Laser- acid-triggered release can significantly increase intracellular H2O2 content, cooperate ions lipid ROS activate ferroptosis. Furthermore, induced arrest temperature-sensitive S-phase, increased levels contributed degradation HSPs protein expression. This synergistic approach could effectively induce death by sensitized PTT combination ferroptosis chemotherapy. Our also maximize eradication prolong survival time tumor-bearing mice vivo. will provide more possibilities clinical applications potential avenues development multiple treatments.

Язык: Английский

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Peptide‐Appended Nanosonosensitizers Targeting Tumor Glycolysis for Synergistic Sonodynamic–Immunometabolic Therapy of Spinal‐Metastasized Tumors

Advanced Materials, Год журнала: 2023, Номер 35(42)

Опубликована: Июль 18, 2023

Despite recent advancements in cancer immunotherapy, challenges have yet to be surmounted achieve two major goals of magnifying antitumor immunity and remodeling the immunosuppressive tumor microenvironment. Here, a nanosystem (ODM-R) that integrates oxygen-deficient molybdenum oxide (ODM) nanosonosensitizers R7 peptides with metabolism regulation effects is designed fabricated for synergistic sonodynamic-immunometabolic therapy spinal-metastasized tumors. The ODM generates reactive oxygen species upon ultrasound irradiation implement sonodynamic (SDT), inducing cell apoptosis immunogenic death. attached on markedly inhibits uptake glucose excretion lactic acid cells by perturbing glycolysis process. combination SDT obstruction ODM-R guarantees satisfactory efficacy synergizing PD-L1 antibody eradicate tumors, achieving concurrent sonodynamic-triggered immune activation microenvironment remodeling. This work provides proof-of-concept boosting immunotherapy metabolic regulation.

Язык: Английский

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Activating MoO₃ nanobelts via aqueous intercalation as a near‐infrared type I photosensitizer for photodynamic periodontitis treatment

SmartMat, Год журнала: 2023, Номер 4(6)

Опубликована: Сен. 13, 2023

Abstract Although molybdenum trioxide nanomaterials have been widely explored as nanoagents for biomedical applications against bacteria through photothermal therapy, chemodynamic and catalytic their utilization photosensitizers photodynamic therapy (PDT) rarely reported so far. Herein, we report the activation of MoO 3 nanobelts via aqueous co‐intercalation Na + H 2 O into van der Waals gaps a near‐infrared Type I photosensitizer periodontitis treatment. The /H intercalation can shorten its length, generate rich oxygen vacancies, enlarge interlayer gaps. Such structural changes thus induce color change from white to dark blue with strong (NIR) absorption. When used photosensitizer, I‐MoO 3− x exhibit much higher activities generation superoxide radical (·O − ) under an 808 nm laser irradiation than that pristine nanobelts. Therefore, prepared show spectral antibacterial activity Escherichia coli Saccharomyces aureus , yielding good clinical therapeutic effect on periodontitis. Our study proves be simple but powerful strategy activate layered high‐performance PDT.

Язык: Английский

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Preparation of 2D Polyaniline/MoO_3−x Superlattice Nanosheets via Intercalation‐Induced Morphological Transformation for Efficient Chemodynamic Therapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(11)

Опубликована: Янв. 5, 2023

Abstract Organic intercalation of layered nanomaterials is an attractive strategy to fabricate organic/inorganic superlattices for a wide range promising applications. However, the synthesis 2D superlattice nanosheets remains big challenge. Herein, preparation polyaniline/MoO 3− x (PANI/MoO ) via intercalation‐induced morphological transformation from MoO 3 nanobelts, as efficient Fenton‐like reagents chemodynamic therapy (CDT), reported. Micrometer‐long nanobelts are co‐intercalated with Na + /H 2 O followed by guest exchange aniline monomer in situ polymerization obtain PANI/MoO nanosheets. Intriguingly, PANI can induce long along partial reduction Mo 6+ 5+ , and generation rich oxygen vacancies. More importantly, thanks activation, exhibit excellent catalytic activity hydroxyl radical (·OH) decomposing H compared nanobelts. It speculated that good conductivity facilitate electron transport during reaction, thereby enhancing efficiency CDT. Thus, polyvinylpyrrolidone‐modified function highly CDT kill cancer cells eradicate tumors.

Язык: Английский

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