Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 155075 - 155075
Опубликована: Авг. 23, 2024
Язык: Английский
EBioMedicine, Год журнала: 2024, Номер 107, С. 105301 - 105301
Опубликована: Авг. 23, 2024
Increasing evidence indicates that immunotherapy is hindered by a hostile tumor microenvironment (TME) featured with deprivation of critical nutrients and pooling immunosuppressive metabolites. Tumor cells outcompete immune effector for essential nutrients. Meanwhile, wide range cell-derived toxic metabolites exerts negative impacts on anti-tumor response, diminishing the efficacy immunotherapy. Nanomedicine excellent targetability offers novel approach to improving cancer via metabolically reprogramming TME. Herein, we review recent strategies enhancing immunotherapeutic effects through rewiring metabolism nanomedicine. Attention drawn immunometabolic tactics stromal in TME Additionally, discuss future directions developing metabolism-regulating nanomedicine precise efficacious
Язык: Английский
Процитировано
75
ACS Nano, Год журнала: 2024, Номер 18(15), С. 10495 - 10508
Опубликована: Апрель 1, 2024
Sonodynamic therapy (SDT) has promising application prospects in tumor therapy. However, SDT does not eradicate metastatic tumors. Herein, Cu-substituted ZnAl ternary layered double hydroxide nanosheets (ZCA NSs) were developed as both sonosensitizers and copper nanocarriers for synergistic SDT/cuproptosis cancer An optimized electronic structure more conducive to the sonodynamic process was obtained from ZCA NSs via Jahn–Teller effect induced by introduction of Cu2+, synthesized regulated intricate microenvironment (TME) depleting endogenous glutathione (GSH) amplify oxidative stress further enhanced performance. Furthermore, cuproptosis evoked intracellular overload Cu2+ amplified SDT, leading irreversible proteotoxicity. In vitro results showed that such synergetic triggered immunogenic cell death (ICD) promoted maturation dendritic cells (DCs). as-synthesized NS-mediated thoroughly eradicated vivo solid tumors simultaneously elicited antitumor immunity suppress lung liver metastasis. Overall, this work established a nanoplatform with satisfactory immunity.
Язык: Английский
Процитировано
38
Advanced Materials, Год журнала: 2024, Номер 36(27)
Опубликована: Март 23, 2024
Abstract Triple negative breast cancer (TNBCs), known as an immunologically cold tumor, is difficult to completely eliminate with existing monotherapies, let alone metastasis and recurrence. It urgent design a rational combination of multiple therapies programmatically reconstitute tumor microenvironment (TME) reverse the immune “cold” into “hot” inflammatory tumors improve therapeutic effect. Hence, in this work, multifunctional nanosystem (FeSH NPs) that integrates metal‐polyphenol coordination complex photothermal agent polyphenol, salvianolic acid B (SAB) immunomodulator designed fabricated for synergistic photothermal‐immunotherapy TNBCs combined anti‐PD‐L1 antibody. Guided by photothermal/photoacoustic dual‐mode imaging, therapy (PTT) caused FeSH NPs induces immunogenic cell death (ICD) under 808 nm laser irradiation. Subsequently, loaded SAB released addition deferoxamine mesylate (DFO) remodel TME, specifically TGF‐β inhibition PD‐L1 upregulation, primary tumors. The PTT TME reprogramming further synergizes antibody eradicate recurrence inhibit concurrently. Given biosafety throughout lifecycle, work provides protocol high clinical translational promise comprehensive programmed therapeutics TNBCs.
Язык: Английский
Процитировано
16
Small, Год журнала: 2024, Номер 20(44)
Опубликована: Июль 6, 2024
Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.
Язык: Английский
Процитировано
11
Advanced Materials, Год журнала: 2024, Номер 36(37)
Опубликована: Фев. 9, 2024
Abstract The diagnosis and treatment of solid tumors have undergone significant advancements marked by a trend toward increased specificity integration imaging therapeutic functions. multifaceted nature inorganic oxide nanomaterials (IONs), which boast optical, magnetic, ultrasonic, biochemical modulatory properties, makes them ideal building blocks for developing multifunctional nanoplatforms. A promising class materials that emerged in this context are peptide‐functionalized (PFIONs), demonstrated excellent performance therapy, making potential candidates advancing tumor treatment. Owing to the functionalities peptides targeting, penetration, responsiveness, well‐designed PFIONs can specifically accumulate release or agents at sites, enabling precise effective This review provides an overview recent advances use tumors, highlighting superiority as well synergistic Moreover, discusses challenges prospects depth, aiming promote intersection interdisciplinary facilitate their clinical translation development personalized diagnostic systems optimizing material systems.
Язык: Английский
Процитировано
10
ACS Nano, Год журнала: 2024, Номер unknown
Опубликована: Фев. 8, 2024
Sono-immunotherapy faces challenges from poor immunogenicity and low response rate due to complex biological barriers. Herein, we prepared MCTH nanocomposites (NCs) consisting of disulfide bonds (S-S) doped mesoporous organosilica (MONs), Cu-modified protoporphyrin (CuPpIX), mitochondria-targeting triphenylphosphine (TPP), CD44-targeting hyaluronic acid (HA). NCs efficiently accumulate at the tumor site overexpressed CD44 receptors on membrane cancer cells. Under function HAase glutathione (GSH), degrades exposes TPP deliver CuPpIX mitochondrial induce a reactive oxygen species (ROS) burst in situ under ultrasound irradiations, thereby causing severe mitochondria dysfunction. This cascade-targeting ability not only reinforces oxidative stress cells but also amplifies immunogenic cell death (ICD) stimulate body's immune alleviate immunosuppressive microenvironment. These significantly enhance infiltration into tumor, particularly CD8+ T cells, for powerful antitumor sono-immunotherapy. The proposed strategy holds promise strengthening sono-immunotherapy prostate treatment overcoming limitations traditional immunotherapy.
Язык: Английский
Процитировано
10
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 7, 2024
Immune checkpoint blockade (ICB) immunotherapy remains hampered by insufficient immunogenicity and a high-lactate immunosuppressive tumor microenvironment (TME). Herein, nanobody-engineered NIR-II nanoadjuvant with targeting metabolic reprogramming capability is constructed for potentiating photothermal-ferroptosis immunotherapy. Specifically, the (2DG@FS-Nb) prepared metallic iron ion-mediated coordination self-assembly of D-A-D type molecules loading glycolysis inhibitor, 2-deoxy-D-glucose (2DG), followed modification aPD-L1 nanobody (Nb), which can effectively target TME trigger in situ immune blockade. The nanoadjuvants responsively release therapeutic components acidic TME, enabling precise location fluorescence/photoacoustic imaging while initiating therapy. remarkable photothermal efficiency elevated glutathione (GSH) depletion further sensitize ferroptosis to induce severe lipid peroxidation, provoking robust immunogenic cell death (ICD) anti-tumor response. Importantly, released 2DG markedly inhibits lactate generation through obstruction. Decreased efflux remodels suppressing M2 macrophage proliferation downregulating regulatory T levels. This work provides new paradigm integration phototheranostics metabolism regulation into single nanoplatform amplified combined ICB
Язык: Английский
Процитировано
9
Chemistry of Materials, Год журнала: 2024, Номер 36(3), С. 1088 - 1112
Опубликована: Янв. 29, 2024
Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting anticancer response, has emerged as promising approach for counteracting evasive tactics of cancer cells. This study delves into innovative realm stimuli-responsive polymeric nanomedicines in context immunotherapy. By capitalizing on intricate landscape tumor microenvironment (TME), which orchestrates suppression and progression, offer tailored strategy enhance therapeutic interventions. The aberrant features TME, include factors such low pH, inflammation, oxidative stress, enzyme overexpression, serve triggers intelligent delivery systems facilitated by functional polymers. dynamic potential overcome challenges faced traditional nanoparticle-based immunotherapy techniques, presenting platform precisely optimize drug within locale. As synergistic interaction between TME unfolds, novel horizon emerges advance efficacy while mitigating its associated limitations.
Язык: Английский
Процитировано
8
Chemical Engineering Journal, Год журнала: 2024, Номер 483, С. 149248 - 149248
Опубликована: Фев. 2, 2024
Язык: Английский
Процитировано
8
Trends in Immunology, Год журнала: 2024, Номер 45(7), С. 549 - 563
Опубликована: Июнь 23, 2024
Язык: Английский
Процитировано
8