Printed Electronic Devices and Systems for Interfacing with Single Cells up to Organoids DOI Creative Commons
M. Saghafi, Srivatsan K. Vasantham, Navid Hussain

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 34(20)

Опубликована: Дек. 13, 2023

Abstract The field of bioelectronics with the aim to contact cells, cell clusters, biological tissues and organoids has become a vast enterprise. Currently, it is mainly relying on classical micro‐ nanofabrication methods build devices systems. Very recently highly pushed by development novel printable organic, inorganic biomaterials as well advanced digital printing technologies such laser inkjet employed in this endeavor. Recent advantages alternative additive manufacturing 3D enable interesting new routes, particular for applications requiring incorporation delicate or creation scaffold structures that show high potential building hybrid bio‐/inorganic devices. Here current state printed 2D electronic related lithography techniques interfacing systems are reviewed. focus lies vitro single cell, organoids. Challenges future prospects discussed all‐printed bio/electronic targeting biomedical research, diagnostics, health monitoring.

Язык: Английский

Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation in Vitro, in Both a Normal and Inflammatory Milieu DOI Creative Commons
Leonardo Ricotti, Andrea Cafarelli, Cristina Manferdini

и другие.

ACS Nano, Год журнала: 2024, Номер 18(3), С. 2047 - 2065

Опубликована: Янв. 2, 2024

The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration different tissue types. However, it has never been explored boosting chondrogenesis. Furthermore, parameters used are often not adequately controlled. In this study, we show that adipose-tissue-derived mesenchymal stromal cells embedded in nanocomposite hydrogel containing barium titanate nanoparticles and graphene oxide nanoflakes stimulated waves precisely controlled (1 MHz 250 mW/cm2, 5 min once every 2 days 10 days) dramatically boost chondrogenic cell commitment vitro. Moreover, fibrotic catabolic factors strongly down-modulated: proteomic analyses reveal such influences biological processes involved cytoskeleton extracellular matrix organization, collagen fibril metabolic processes. optimal regimen also considerable anti-inflammatory effect keeps its ability to chondrogenesis vitro, even an inflammatory milieu. An analytical model predict voltage generated by invested proposed, together computational tool takes into consideration nanoparticle clustering within vacuoles predicts electric field streamline distribution cytoplasm. proposed shows good injectability adhesion cartilage ex vivo, well excellent biocompatibility according ISO 10993. Future perspectives will involve preclinical testing paradigm regeneration.

Язык: Английский

Процитировано

30
A Biodegradable Piezoelectric Sensor for Real‐Time Evaluation of the Motor Function Recovery After Nerve Injury DOI

Yizhu Shan,

Engui Wang,

Xi Cui

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Март 22, 2024

Abstract Nerve injury can lead to defects in related motor functions. It is critical achieve long‐term and convenient real‐time evaluation of function recovery status during nerve repair. In this study, an implantable PLLA/BTO piezoelectric sensor (PBPS) with good biodegradability biocompatibility for real time the after developed. PLLA fibers doped BTO are employed as material PBPS, which convert biomechanical signals generated by motion into electrical signals. PBPS be implant simultaneously commonly used tissue scaffolds treatment rats sciatic injury. The linearity pressure output voltage ≈0.9445. For effectiveness, process progresses, exhibited consistency EMG signals, indicating effectively function. Moreover, integration wireless module break limitations space sensing realize rat. based on may bring new ideas development bioelectronics.

Язык: Английский

Процитировано

30
Degradable piezoelectric biomaterials for medical applications DOI Creative Commons
Yuan Bai, Hongyu Meng, Zhou Li

и другие.

MedMat., Год журнала: 2024, Номер 1(1), С. 40 - 49

Опубликована: Май 13, 2024

The energy harvesting technology based on piezoelectricity promises to achieve a self-powered mode for portable medical electronic devices. Piezoelectric materials, as crucial components in electromechanical applications, have extensively been utilized Especially, degradable piezoelectric biomaterials received much attention the field due their excellent biocompatibility and biosafety. This mini-review mainly summarizes types structural characteristics of from small-molecule crystals polymers. Afterward, applications are briefly introduced, including harvester sensor, actuator transducer, tissue engineering scaffold. Finally, material perspective, some challenges currently faced by proposed.

Язык: Английский

Процитировано

19
Advancements in Metal and Metal Oxide Nanoparticles for Targeted Cancer Therapy and Imaging: Mechanisms, Applications, and Safety Concerns DOI Creative Commons
Jameema Sidhic, Aswathi Moothakoottil Kuttithodi, Aparna Prasad

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106622 - 106622

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

5
Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives DOI Creative Commons
Yubin Yao, Xi Cui, Shenglong Ding

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Abstract Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for regeneration, making electrical materials a promising therapy. This review provides comprehensive overview of the role bioelectric signals cells, alongside recent advancements biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, zwitterionic hydrogels. It further investigates impact these biomaterials as well applications both exogenous stimulation (ES) mechanisms underlying ES‐induced cellular molecular responses. Finally, underscores future directions ES systems tissue engineering, emphasizing critical importance integrating structural integrity, mechanical properties, signal delivery into intelligent implantable scaffolds.

Язык: Английский

Процитировано

4
Piezoelectric PVDF Nanoparticles for Enhanced Antimicrobial Activity via Mechanical Stimulation: A Proof-of-Concept Study DOI
Mariana Fernandes, Joana Moreira, Marta Fernandes

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

The alarming rise of antimicrobial resistance is a public health issue, driven by the excessive and improper use antibiotics, which are becoming less effective against an increasing number microorganisms. There urgent need to find alternative strategies that can bypass bacterial mechanisms. Using physical stimuli sensitize bacteria action one step toward addressing this challenge. In work, piezoelectric poly(vinylidene fluoride) (PVDF) nanoparticles were developed in attempt control enhance activity materials through stimulation. exhibited sizes ranging from 200 400 nm, with low polydispersity, negative surface charge, spherical smooth morphology. reprecipitation methodology, synthesized crystallization PVDF electroactive β-phase, achieving percentages formulations greater than 80%. These demonstrated promising properties, considerably enhanced dynamic conditions involving mechanical stimulation resulting creation microenvironments. Notably, approach stronger inhibitory effect on growth, particularly Escherichia coli. When water was used as nonsolvent for concentration 10 mg/mL, it resulted inhibition, reductions 1.33 log10 under static 2.21 conditions. However, pronounced Staphylococcus aureus. contrast, when 50% ethanol solution nonsolvent, both significant reductions: E. coli completely eradicated conditions, while S. aureus showed 1.93 reduction. Under eliminated. Although these compromise viability human fibroblasts after 72 h contact, study provides proof-of-concept findings open possibilities developing hygienic coatings surfaces, leveraging pressure or touch activate antibacterial effects.

Язык: Английский

Процитировано

3
Piezoelectric Nanomaterials Activated by Ultrasound in Disease Treatment DOI Creative Commons

Shiyuan Yang,

Yuan Wang, Xiaolong Liang

и другие.

Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1338 - 1338

Опубликована: Апрель 26, 2023

Electric stimulation has been used in changing the morphology, status, membrane permeability, and life cycle of cells to treat certain diseases such as trauma, degenerative disease, tumor, infection. To minimize side effects invasive electric stimulation, recent studies attempt apply ultrasound control piezoelectric effect nano material. This method not only generates an field but also utilizes benefits non-invasive mechanical effects. In this review, important elements system, piezoelectricity nanomaterial ultrasound, are first analyzed. Then, we summarize categorized into five kinds, nervous system treatment, musculoskeletal tissues cancer anti-bacteria therapy, others, prove two main mechanics under activated piezoelectricity: one is biological change on a cellular level, other piezo-chemical reaction. However, there still technical problems be solved regulation processes completed before widespread use. The core include how accurately measure properties, concisely electricity release through complex energy transfer processes, deeper understanding related bioeffects. If these conquered future, nanomaterials by will provide new pathway realize application disease treatment.

Язык: Английский

Процитировано

25
Bio-inspired structures for energy harvesting self-powered sensing and smart monitoring DOI

Yingxuan Cui,

Hongchun Luo,

Tao Yang

и другие.

Mechanical Systems and Signal Processing, Год журнала: 2025, Номер 228, С. 112459 - 112459

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

2
The potential application of electrical stimulation in tendon repair: a review DOI Creative Commons
Xiao Yu,

Yihong Shen,

Jie Cui

и другие.

Med-X, Год журнала: 2025, Номер 3(1)

Опубликована: Март 4, 2025

Язык: Английский

Процитировано

2
Tumor microenvironment-responsive self-assembly of barium titanate nanoparticles with enhanced piezoelectric catalysis capabilities for efficient tumor therapy DOI Creative Commons

Zhuo Xiang,

Lingling Xu,

Yizhu Shan

и другие.

Bioactive Materials, Год журнала: 2023, Номер 33, С. 251 - 261

Опубликована: Ноя. 20, 2023

Catalytic therapy based on piezoelectric nanoparticles has become one of the effective strategies to eliminate tumors. However, it is still a challenge improve tumor delivery efficiency nanoparticles, so that they can penetrate normal tissues while specifically aggregating at sites and subsequently generating large amounts reactive oxygen species (ROS) achieve precise efficient clearance. In present study, we successfully fabricated microenvironment-responsive assembled barium titanate (tma-BTO NPs): in neutral pH environment tissues, tma-BTO NPs were monodisperse possessed ability cross intercellular space; whereas, acidic triggered self-assembly form submicron-scale aggregates, deposited microenvironment. The self-assembled not only caused mechanical damage cells; more interestingly, also exhibited enhanced catalytic produced ROS than under ultrasonic excitation, attributed mutual extrusion neighboring particles within confined space assembly. differential cytotoxicity against cells cells, stronger catalysis induced by assemblies resulted significant apoptosis mouse breast cancer (4T1); there was little embryo osteoblast precursor (MC3T3-E1) same treatment conditions. Animal experiments confirmed peritumoral injection combined with ultrasound effectively inhibit progression non-invasively. strategy opens up new perspectives for future piezoelectric-catalyzed therapy.

Язык: Английский

Процитировано

21