Advanced Functional Materials,
Год журнала:
2023,
Номер
34(20)
Опубликована: Дек. 13, 2023
Abstract
The
field
of
bioelectronics
with
the
aim
to
contact
cells,
cell
clusters,
biological
tissues
and
organoids
has
become
a
vast
enterprise.
Currently,
it
is
mainly
relying
on
classical
micro‐
nanofabrication
methods
build
devices
systems.
Very
recently
highly
pushed
by
development
novel
printable
organic,
inorganic
biomaterials
as
well
advanced
digital
printing
technologies
such
laser
inkjet
employed
in
this
endeavor.
Recent
advantages
alternative
additive
manufacturing
3D
enable
interesting
new
routes,
particular
for
applications
requiring
incorporation
delicate
or
creation
scaffold
structures
that
show
high
potential
building
hybrid
bio‐/inorganic
devices.
Here
current
state
printed
2D
electronic
related
lithography
techniques
interfacing
systems
are
reviewed.
focus
lies
vitro
single
cell,
organoids.
Challenges
future
prospects
discussed
all‐printed
bio/electronic
targeting
biomedical
research,
diagnostics,
health
monitoring.
ACS Nano,
Год журнала:
2024,
Номер
18(3), С. 2047 - 2065
Опубликована: Янв. 2, 2024
The
use
of
piezoelectric
nanomaterials
combined
with
ultrasound
stimulation
is
emerging
as
a
promising
approach
for
wirelessly
triggering
the
regeneration
different
tissue
types.
However,
it
has
never
been
explored
boosting
chondrogenesis.
Furthermore,
parameters
used
are
often
not
adequately
controlled.
In
this
study,
we
show
that
adipose-tissue-derived
mesenchymal
stromal
cells
embedded
in
nanocomposite
hydrogel
containing
barium
titanate
nanoparticles
and
graphene
oxide
nanoflakes
stimulated
waves
precisely
controlled
(1
MHz
250
mW/cm2,
5
min
once
every
2
days
10
days)
dramatically
boost
chondrogenic
cell
commitment
vitro.
Moreover,
fibrotic
catabolic
factors
strongly
down-modulated:
proteomic
analyses
reveal
such
influences
biological
processes
involved
cytoskeleton
extracellular
matrix
organization,
collagen
fibril
metabolic
processes.
optimal
regimen
also
considerable
anti-inflammatory
effect
keeps
its
ability
to
chondrogenesis
vitro,
even
an
inflammatory
milieu.
An
analytical
model
predict
voltage
generated
by
invested
proposed,
together
computational
tool
takes
into
consideration
nanoparticle
clustering
within
vacuoles
predicts
electric
field
streamline
distribution
cytoplasm.
proposed
shows
good
injectability
adhesion
cartilage
ex
vivo,
well
excellent
biocompatibility
according
ISO
10993.
Future
perspectives
will
involve
preclinical
testing
paradigm
regeneration.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(33)
Опубликована: Март 22, 2024
Abstract
Nerve
injury
can
lead
to
defects
in
related
motor
functions.
It
is
critical
achieve
long‐term
and
convenient
real‐time
evaluation
of
function
recovery
status
during
nerve
repair.
In
this
study,
an
implantable
PLLA/BTO
piezoelectric
sensor
(PBPS)
with
good
biodegradability
biocompatibility
for
real
time
the
after
developed.
PLLA
fibers
doped
BTO
are
employed
as
material
PBPS,
which
convert
biomechanical
signals
generated
by
motion
into
electrical
signals.
PBPS
be
implant
simultaneously
commonly
used
tissue
scaffolds
treatment
rats
sciatic
injury.
The
linearity
pressure
output
voltage
≈0.9445.
For
effectiveness,
process
progresses,
exhibited
consistency
EMG
signals,
indicating
effectively
function.
Moreover,
integration
wireless
module
break
limitations
space
sensing
realize
rat.
based
on
may
bring
new
ideas
development
bioelectronics.
MedMat.,
Год журнала:
2024,
Номер
1(1), С. 40 - 49
Опубликована: Май 13, 2024
The
energy
harvesting
technology
based
on
piezoelectricity
promises
to
achieve
a
self-powered
mode
for
portable
medical
electronic
devices.
Piezoelectric
materials,
as
crucial
components
in
electromechanical
applications,
have
extensively
been
utilized
Especially,
degradable
piezoelectric
biomaterials
received
much
attention
the
field
due
their
excellent
biocompatibility
and
biosafety.
This
mini-review
mainly
summarizes
types
structural
characteristics
of
from
small-molecule
crystals
polymers.
Afterward,
applications
are
briefly
introduced,
including
harvester
sensor,
actuator
transducer,
tissue
engineering
scaffold.
Finally,
material
perspective,
some
challenges
currently
faced
by
proposed.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Severe
bone
and
cartilage
defects
caused
by
trauma
are
challenging
to
treat,
often
resulting
in
poor
outcomes.
An
endogenous
electric
field
(EnEF)
is
crucial
for
regeneration,
making
electrical
materials
a
promising
therapy.
This
review
provides
comprehensive
overview
of
the
role
bioelectric
signals
cells,
alongside
recent
advancements
biomaterials,
with
particular
emphasis
on
nanogenerators,
piezoelectric
materials,
triboelectric
scaffolds,
zwitterionic
hydrogels.
It
further
investigates
impact
these
biomaterials
as
well
applications
both
exogenous
stimulation
(ES)
mechanisms
underlying
ES‐induced
cellular
molecular
responses.
Finally,
underscores
future
directions
ES
systems
tissue
engineering,
emphasizing
critical
importance
integrating
structural
integrity,
mechanical
properties,
signal
delivery
into
intelligent
implantable
scaffolds.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
The
alarming
rise
of
antimicrobial
resistance
is
a
public
health
issue,
driven
by
the
excessive
and
improper
use
antibiotics,
which
are
becoming
less
effective
against
an
increasing
number
microorganisms.
There
urgent
need
to
find
alternative
strategies
that
can
bypass
bacterial
mechanisms.
Using
physical
stimuli
sensitize
bacteria
action
one
step
toward
addressing
this
challenge.
In
work,
piezoelectric
poly(vinylidene
fluoride)
(PVDF)
nanoparticles
were
developed
in
attempt
control
enhance
activity
materials
through
stimulation.
exhibited
sizes
ranging
from
200
400
nm,
with
low
polydispersity,
negative
surface
charge,
spherical
smooth
morphology.
reprecipitation
methodology,
synthesized
crystallization
PVDF
electroactive
β-phase,
achieving
percentages
formulations
greater
than
80%.
These
demonstrated
promising
properties,
considerably
enhanced
dynamic
conditions
involving
mechanical
stimulation
resulting
creation
microenvironments.
Notably,
approach
stronger
inhibitory
effect
on
growth,
particularly
Escherichia
coli.
When
water
was
used
as
nonsolvent
for
concentration
10
mg/mL,
it
resulted
inhibition,
reductions
1.33
log10
under
static
2.21
conditions.
However,
pronounced
Staphylococcus
aureus.
contrast,
when
50%
ethanol
solution
nonsolvent,
both
significant
reductions:
E.
coli
completely
eradicated
conditions,
while
S.
aureus
showed
1.93
reduction.
Under
eliminated.
Although
these
compromise
viability
human
fibroblasts
after
72
h
contact,
study
provides
proof-of-concept
findings
open
possibilities
developing
hygienic
coatings
surfaces,
leveraging
pressure
or
touch
activate
antibacterial
effects.
Pharmaceutics,
Год журнала:
2023,
Номер
15(5), С. 1338 - 1338
Опубликована: Апрель 26, 2023
Electric
stimulation
has
been
used
in
changing
the
morphology,
status,
membrane
permeability,
and
life
cycle
of
cells
to
treat
certain
diseases
such
as
trauma,
degenerative
disease,
tumor,
infection.
To
minimize
side
effects
invasive
electric
stimulation,
recent
studies
attempt
apply
ultrasound
control
piezoelectric
effect
nano
material.
This
method
not
only
generates
an
field
but
also
utilizes
benefits
non-invasive
mechanical
effects.
In
this
review,
important
elements
system,
piezoelectricity
nanomaterial
ultrasound,
are
first
analyzed.
Then,
we
summarize
categorized
into
five
kinds,
nervous
system
treatment,
musculoskeletal
tissues
cancer
anti-bacteria
therapy,
others,
prove
two
main
mechanics
under
activated
piezoelectricity:
one
is
biological
change
on
a
cellular
level,
other
piezo-chemical
reaction.
However,
there
still
technical
problems
be
solved
regulation
processes
completed
before
widespread
use.
The
core
include
how
accurately
measure
properties,
concisely
electricity
release
through
complex
energy
transfer
processes,
deeper
understanding
related
bioeffects.
If
these
conquered
future,
nanomaterials
by
will
provide
new
pathway
realize
application
disease
treatment.
Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 251 - 261
Опубликована: Ноя. 20, 2023
Catalytic
therapy
based
on
piezoelectric
nanoparticles
has
become
one
of
the
effective
strategies
to
eliminate
tumors.
However,
it
is
still
a
challenge
improve
tumor
delivery
efficiency
nanoparticles,
so
that
they
can
penetrate
normal
tissues
while
specifically
aggregating
at
sites
and
subsequently
generating
large
amounts
reactive
oxygen
species
(ROS)
achieve
precise
efficient
clearance.
In
present
study,
we
successfully
fabricated
microenvironment-responsive
assembled
barium
titanate
(tma-BTO
NPs):
in
neutral
pH
environment
tissues,
tma-BTO
NPs
were
monodisperse
possessed
ability
cross
intercellular
space;
whereas,
acidic
triggered
self-assembly
form
submicron-scale
aggregates,
deposited
microenvironment.
The
self-assembled
not
only
caused
mechanical
damage
cells;
more
interestingly,
also
exhibited
enhanced
catalytic
produced
ROS
than
under
ultrasonic
excitation,
attributed
mutual
extrusion
neighboring
particles
within
confined
space
assembly.
differential
cytotoxicity
against
cells
cells,
stronger
catalysis
induced
by
assemblies
resulted
significant
apoptosis
mouse
breast
cancer
(4T1);
there
was
little
embryo
osteoblast
precursor
(MC3T3-E1)
same
treatment
conditions.
Animal
experiments
confirmed
peritumoral
injection
combined
with
ultrasound
effectively
inhibit
progression
non-invasively.
strategy
opens
up
new
perspectives
for
future
piezoelectric-catalyzed
therapy.
Biomaterials Science,
Год журнала:
2024,
Номер
12(20), С. 5164 - 5185
Опубликована: Янв. 1, 2024
In
recent
years,
poly(vinylidene
fluoride)
(PVDF)
has
emerged
as
a
versatile
polymer
with
wide
range
of
applications
across
various
fields.
PVDF's
piezosensitivity,
versatility,
crystalline
structure,
and
tunable
parameters
have
established
it
highly
sought-after
material.
Furthermore,
PVDF
its
copolymers
exhibit
excellent
processability
chemical
resistance
to
diverse
array
substances.
Of
particular
significance
is
remarkable
structural
stability
in
physiological
media,
which
highlights
potential
for
use
the
development
biomedical
products.
This
review
offers
comprehensive
overview
latest
advancements
PVDF-based
systems.
It
examines
fabrication
stimulus-responsive
delivery
systems,
bioelectric
therapy
devices,
tissue-regenerating
scaffolds,
all
harness
piezosensitivity
PVDF.
Moreover,
both
invasive
non-invasive
diagnostic
tools
investigated,
emphasis
on
flexibility,
transparency,
piezoelectric
efficiency.
The
material's
high
biocompatibility
are
paramount
importance
implantable
sensors
long-term
health
monitoring,
crucial
management
chronic
diseases
postoperative
care.
Additionally,
we
discuss
novel
approach
photoacoustic
microscopy
that
employs
sensor,
thereby
eliminating
necessity
external
contrast
agents.
technique
provides
new
avenue
imaging
applications.
Finally,
explore
challenges
prospects
systems
distinctive
comparison
other
reviews
due
concentrated
examination
applications,
including
pioneering
techniques,
detailed
account
field.
Collectively,
these
elements
illustrate
markedly
influence
engineering
patient
care,
distinguishing
from
existing
literature.
By
leveraging
attributes
copolymers,
researchers
can
continue
advance
frontiers
engineering,
transform
care
treatment
outcomes.