ACS Omega,
Год журнала:
2024,
Номер
9(45), С. 44860 - 44875
Опубликована: Ноя. 1, 2024
A
diabetic
wound
exemplifies
the
challenge
of
chronic,
nonhealing
wounds.
Elevated
blood
sugar
levels
in
diabetes
profoundly
disrupt
macrophage
function,
impairing
crucial
activities
such
as
phagocytosis,
immune
response,
cell
migration,
and
vessel
formation,
all
essential
for
effective
healing.
Moreover,
persistent
presence
pro-inflammatory
cytokines
reactive
oxygen
species,
coupled
with
a
decrease
anti-inflammatory
factors,
exacerbates
delay
healing
associated
diabetes.
This
review
emphasizes
dysfunctional
inflammatory
responses
underlying
wounds
explores
preclinical
studies
inflammation-modulating
bioactives
biomaterials
that
show
promise
expediting
Additionally,
this
provides
an
overview
selected
clinical
employing
bioactive
molecules,
shedding
light
on
gap
between
extensive
research
limited
field.
Advanced Materials,
Год журнала:
2024,
Номер
36(21)
Опубликована: Фев. 7, 2024
Single-atom
nanozymes
(SAzymes)
showcase
not
only
uniformly
dispersed
active
sites
but
also
meticulously
engineered
coordination
structures.
These
intricate
architectures
bestow
upon
them
an
exceptional
catalytic
prowess,
thereby
captivating
numerous
minds
and
heralding
a
new
era
of
possibilities
in
the
biomedical
landscape.
Tuning
microstructure
SAzymes
on
atomic
scale
is
key
factor
designing
targeted
with
desirable
functions.
This
review
first
discusses
summarizes
three
strategies
for
their
impact
reactivity
biocatalysis.
The
effects
choices
carrier,
different
synthesis
methods,
modulation
first/second
shell,
type
number
metal
centers
enzyme-like
activity
are
unraveled.
Next,
attempt
made
to
summarize
biological
applications
tumor
therapy,
biosensing,
antimicrobial,
anti-inflammatory,
other
from
mechanisms.
Finally,
how
designed
regulated
further
realization
diverse
reviewed
prospected.
It
envisaged
that
comprehensive
presented
within
this
exegesis
will
furnish
novel
perspectives
profound
revelations
regarding
SAzymes.
ACS Nano,
Год журнала:
2024,
Номер
18(9), С. 7024 - 7036
Опубликована: Фев. 23, 2024
Chronic
wounds
frequently
arise
as
a
complication
in
diabetic
patients,
and
their
management
remains
significant
clinical
hurdle
due
to
nonhealing
nature
featured
by
heightened
oxidative
stress
impaired
healing
cells
at
the
wound
site.
Herein,
we
present
2D
copper
antioxidant
nanozyme
induced
phenolic
ligand–metal
charge
transfer
(LMCT)
eliminate
reactive
oxygen
species
(ROS)
facilitate
of
chronic
wounds.
We
found
that
polyphenol
ligands
coordinated
on
Cu3(PO4)2
nanosheets
led
strong
interface
regulated
valence
states
Cu.
The
obtained
Cu
exhibited
efficient
scavenging
ability
toward
different
protected
human
from
damage.
enhanced
promoting
re-epithelialization,
collagen
deposition,
angiogenesis,
immunoregulation.
This
work
demonstrates
LMCT-induced
ROS
nanointerface,
providing
an
alternative
strategy
constructing
metal-based
nanozymes
for
treatment
well
other
diseases.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117058 - 117058
Опубликована: Июль 4, 2024
The
NF-κB
pathway
plays
a
pivotal
role
in
impeding
the
diabetic
wound
healing
process,
contributing
to
prolonged
inflammation,
diminished
angiogenesis,
and
reduced
proliferation.
In
contrast
modern
synthetic
therapies,
naturally
occurring
phytoconstituents
are
well-studied
inhibitors
of
that
now
attracting
increased
attention
context
because
lower
toxicity,
better
safety
efficacy,
cost-effectiveness.
This
study
explores
recent
research
on
phytoconstituent-based
therapies
delve
into
their
action
mechanisms
targeting
potential
for
assisting
effective
wounds.
For
this
purpose,
we
have
carried
out
surveys
literature
analyzed
studies
from
prominent
databases
such
as
Science
Direct,
Scopus,
PubMed,
Google
Scholar,
EMBASE,
Web
Science.
classification
various
categorie
as:
alkaloids,
triterpenoids,
phenolics,
polyphenols,
flavonoids,
monoterpene
glycosides,
naphthoquinones
tocopherols.
Noteworthy
phytoconstituents,
including
Neferine,
Plumbagin,
Boswellic
acid,
Genistein,
Luteolin,
Kirenol,
Rutin,
Vicenin-2,
Gamma-tocopherol,
Icariin,
Resveratrol,
Mangiferin,
Betulinic
Berberine,
Syringic
Gallocatechin,
Curcumin,
Loureirin-A,
Loureirin-B,
Lupeol,
Paeoniflorin,
Puerarin
emerge
these
promising
agents
through
inhibition
pathway.
Extensive
has
revealed
how
they
modulate
signalling
pathways,
NF-κB,
demonstrate
development
therapeutic
assist
chronic
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(5), С. 2660 - 2676
Опубликована: Май 9, 2024
Wound
healing,
particularly
for
chronic
wounds,
presents
a
considerable
difficulty
due
to
differences
in
biochemical
and
cellular
processes
that
occur
different
types
of
wounds.
Recent
technological
breakthroughs
have
notably
advanced
the
understanding
diagnostic
therapeutic
approaches
wound
healing.
The
evolution
care
has
seen
transition
from
traditional
textile
dressings
variety
alternatives,
including
self-healing
hydrogels,
hydrofibers,
foams,
hydrocolloids,
environment
responsive
dressings,
growth
factor-based
therapy,
bioengineered
skin
substitutes,
stem
cell
gene
therapy.
Technological
advancements,
such
as
3D
printing
electronic
(e-skin)
contribute
customization
Despite
these
effectively
managing
wounds
remains
challenging.
This
necessitates
development
treatments
consider
performance,
risk–benefit
balance,
cost-effectiveness.
review
discusses
innovative
strategies
healing
Incorporating
biomarkers
into
coupled
with
corresponding
biosensors
drug
delivery
formulations,
enables
theranostic
approach
treatment
Furthermore,
integrating
power
sources
user
interfaces
like
near-field
communication,
radio
frequency
identification,
Bluetooth
enhances
real-time
monitoring
on-demand
delivery.
It
also
provides
thorough
evaluation
advantages,
patient
compliance,
costs,
durability
emphasizing
smart
formulations
their
preparation
methods.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
Patients
and
healthcare
systems
face
significant
social
financial
challenges
due
to
the
increasing
number
of
individuals
with
chronic
external
internal
wounds
that
fail
heal.
The
complexity
healing
process
remains
a
serious
health
concern,
despite
effectiveness
conventional
wound
dressings
in
promoting
healing.
Recent
advancements
materials
science
fabrication
techniques
have
led
development
innovative
enhance
To
further
expedite
process,
novel
approaches
such
as
nanoparticles,
3D-printed
dressings,
biomolecule-infused
emerged,
along
cell-based
methods.
Additionally,
gene
therapy
technologies
are
being
harnessed
generate
stem
cell
derivatives
more
functional,
selective,
responsive
than
their
natural
counterparts.
This
review
highlights
potential
biomaterials,
3D
bioprinting,
gene-
therapies
However,
it
also
underscores
necessity
for
research
address
existing
integrate
these
strategies
into
standard
clinical
practice.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Abstract
Diabetic
wound
healing
presents
a
persistent
clinical
challenge,
often
characterized
by
prolonged
times,
and
can
be
particularly
difficult
to
achieve
in
hyperglycemic
environment.
In
this
study,
multi‐functional
silver‐enzyme
nanogels
assembly
(Ag‐nGHC)
is
designed
focusing
on
the
complex
diabetic
Glucose
oxidase
(GOX),
horseradish
peroxidase
(HRP),
catalase
(CAT)
are
modified
within
polymeric
nanogel
layers
assembled
into
large
enzyme
cluster
with
silver
ions.
The
close
attachment
of
three
enzymes
ensures
fast
continuous
consumption
high
level
glucose,
generation
oxygen,
hydroxyl
radicals
(•OH)
around
site.
Meanwhile,
ions
Ag‐nGHC
act
as
an
effective
agent
kill
bacteria.
This
cascade
system
significantly
improves
microenvironment
site
reducing
bacterium
infection
alleviating
hypoxia
well
hyperglycemia.
Sequentially,
improved
environment
facilitates
later
processes
including
anti‐inflammatory,
re‐epithelialization,
angiogenesis,
evidenced
enhancing
polarization
toward
M2
macrophages
increasing
CD31
signals
study.
Overall,
materials
proven
multifunctional
properties
complicated
(attributes
such
adaptability,
hypoxia‐alleviated,
anti‐hyperglycemic,
antimicrobial,
angiogenic)
showed
great
potential
for
treatment
chronic
wound.
