Abstract
Nanozymes
have
been
widely
used
for
treating
reactive
oxygen
species
(ROS)
caused
diseases.
However,
the
ROS‐dependent
antibacterial
property
is
inevitably
damaged
during
process
of
scavenging
ROS,
which
unfavorable
treatment
diseases
related
to
both
ROS
accumulation
and
bacterial
infections.
To
address
issues,
biomedical
materials
with
ROS‐elimination
ability
ROS‐independent
capacity
are
fabricated
via
in
situ
depositing
spherical
Au
nanoparticles
(Au
NPs)
on
rough
surface
metal
organic
frameworks
composed
Ce(III)
terephthalic
acid
(Ce‐BDC@Au
MOFs).
The
synthesized
Ce‐BDC@Au
MOFs
show
multi‐enzymatic
activities
owing
reversible
conversion
between
Ce
3+
4+
,
can
significantly
scavenge
cells.
deposition
NPs
Ce‐BDC
causes
come
close
proximity
forming
plasmon
resonance
coupling,
inducing
wavelength
red
shifted
NIR
region.
Based
this,
good
photothermal
efficiency
under
laser
(808
nm)
irradiation.
Benefitting
from
ability,
high
against
staphylococcus
aureus
through
mechanically
damaging
destruction.
This
strategy
biosafety
effectiveness
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 16, 2024
Abstract
Diabetic
foot
ulcers
(DFU)
are
notoriously
challenging
to
heal
due
severe
infection,
excessive
inflammation,
and
difficulty
in
angiogenesis.
In
response
these
problems,
first,
a
pH/glucose
dual‐responsive
hydrogel
dressing
(HPC)
is
constructed
using
dual
dynamic
crosslinking
through
Schiff
base
phenylboronate
ester
between
m‐aminophenylboronic
acid
adipic
dihydrazide
bifunctionalized
hyaluronic
(AHP)
oxidized
chondroitin
sulfate
(OCS).
Then,
polydopamine‐reduced
graphene
oxide
compounded
glycine‐modified
fullerene
(GPC)
with
photothermal/photodynamic
synergistic
antibacterial
properties
the
drug
pirfenidone
(PFD)
pro‐angiogenesis
suppress
inflammatory
loaded
into
above
HPC
hydrogel.
Based
on
of
base/phenylboronate
pH/glucose,
HPC/GPC/PFD
(HPCG/PFD)
can
accelerate
release
PFD,
thereby
improving
inflammation
angiogenesis
DFU.
addition,
provided
good
on‐demand
removal
self‐healing
performance,
while
GPC
brought
tissue
adhesion,
antioxidation,
electrical
conductivity
The
rheology,
morphology,
mechanical
properties,
swelling,
degradation,
biocompatibility
have
been
well
verified.
Finally,
DFU
model
rats,
this
promote
wound
repair
by
reducing
infection
accelerating
closure,
enhancing
epidermal
regeneration,
collagen
deposition,
angiogenesis,
showing
promoting
effect
diabetic
healing.
