Recent advances of copper-based metal phenolic networks in biomedical applications
Colloids and Surfaces B Biointerfaces,
Год журнала:
2024,
Номер
244, С. 114163 - 114163
Опубликована: Авг. 14, 2024
Язык: Английский
Cleavage of Homonuclear Chalcogen‐Chalcogen Bonds in a Hybrid Platform in Response to X‐Ray Radiation Potentiates Tumor Radiochemotherapy
Yuanyuan You,
Yanzhou Chang,
Shuya Pan
и другие.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
64(1)
Опубликована: Авг. 23, 2024
Chalcogens
are
used
as
sensitive
redox-responsive
reagents
in
tumor
therapy.
However,
chalcogen
bonds
triggered
by
external
ionizing
radiation,
rather
than
internal
environmental
stimuli,
enable
site-directed
and
real-time
drug
degradation
target
lesions.
This
approach
helps
to
bypass
chemoresistance
global
systemic
toxicity,
presenting
a
significant
advancement
over
traditional
chemoradiotherapy.
In
this
study,
we
fabricated
hybrid
monodisperse
organosilica
nanoprodrug
based
on
homonuclear
single
(disulfide
(S-S,
approximately
240
kJ/mol),
diselenium
(Se-Se,
172
tellurium
(Te-Te,
126
kJ/mol)),
including
ditelluride-bond-bridged
MONs
(DTeMSNs),
diselenide-bond-bridged
(DSeMSNs)
disulfide-bond-bridged
(DSMSNs).
The
results
demonstrated
that
differences
electronegativities
atomic
radii
influenced
their
oxidation
sensitivities
reactivities.
Tellurium,
with
the
lowest
electronegativity,
showed
highest
sensitivity,
followed
selenium
sulfur.
DTeMSNs
exhibited
highly
responsive
cleavage
upon
exposure
X-rays,
resulting
TeO
Язык: Английский
Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment
Bioactive Materials,
Год журнала:
2024,
Номер
42, С. 379 - 403
Опубликована: Сен. 10, 2024
Язык: Английский
Self-Regulating Immunosuppressive Tumor Microenvironment by NIR-II Photothermal Agent with Anti-Inflammatory Activity for Self-Reinforcing Immunotherapy Synergy with Cancer Photothermal Ablation
Biomaterials,
Год журнала:
2025,
Номер
318, С. 123187 - 123187
Опубликована: Фев. 13, 2025
Язык: Английский
Regulatory T Cells Engineered with Polyphenol-Functionalized Immunosuppressant Nanocomplexes for Rebuilding Periodontal Hard Tissue under Inflammation-Challenged Microenvironment
Biomaterials,
Год журнала:
2024,
Номер
315, С. 122961 - 122961
Опубликована: Ноя. 9, 2024
Язык: Английский
Cleavage of Homonuclear Chalcogen‐Chalcogen Bonds in a Hybrid Platform in Response to X‐Ray Radiation Potentiates Tumor Radiochemotherapy
Yuanyuan You,
Yanzhou Chang,
Shuya Pan
и другие.
Angewandte Chemie,
Год журнала:
2024,
Номер
137(1)
Опубликована: Авг. 23, 2024
Abstract
Chalcogens
are
used
as
sensitive
redox‐responsive
reagents
in
tumor
therapy.
However,
chalcogen
bonds
triggered
by
external
ionizing
radiation,
rather
than
internal
environmental
stimuli,
enable
site‐directed
and
real‐time
drug
degradation
target
lesions.
This
approach
helps
to
bypass
chemoresistance
global
systemic
toxicity,
presenting
a
significant
advancement
over
traditional
chemoradiotherapy.
In
this
study,
we
fabricated
hybrid
monodisperse
organosilica
nanoprodrug
based
on
homonuclear
single
(disulfide
(S−S,
approximately
240
kJ/mol),
diselenium
(Se−Se,
172
tellurium
(Te−Te,
126
kJ/mol)),
including
ditelluride‐bond‐bridged
MONs
(DTeMSNs),
diselenide‐bond‐bridged
(DSeMSNs)
disulfide‐bond‐bridged
(DSMSNs).
The
results
demonstrated
that
differences
electronegativities
atomic
radii
influenced
their
oxidation
sensitivities
reactivities.
Tellurium,
with
the
lowest
electronegativity,
showed
highest
sensitivity,
followed
selenium
sulfur.
DTeMSNs
exhibited
highly
responsive
cleavage
upon
exposure
X‐rays,
resulting
TeO
3
2−
.
Furthermore,
chalcogen‐hybridized
was
loaded
manganese
ions
(Mn
2+
)
enhance
release
of
Mn
during
radiotherapy,
thereby
activating
stimulator
interferon
genes
(STING)
pathway
enhancing
immune
response
inhibit
growth.
investigation
deepens
our
understanding
chalcogens
characteristics
radiotherapy
enriches
design
principles
for
nanomedicine
prodrugs.
Язык: Английский
In situ vaccine “seeds” for enhancing cancer immunotherapy by exploiting apoptosis-associated morphological changes
Journal of Controlled Release,
Год журнала:
2025,
Номер
379, С. 757 - 767
Опубликована: Янв. 25, 2025
Язык: Английский
Novel Intravenous Formulation for Radiosensitization in Osteosarcoma Treatment
Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101682 - 101682
Опубликована: Март 18, 2025
Язык: Английский
Neoadjuvant chemotherapy by liposomal doxorubicin boosts immune protection of tumor membrane antigens-based nanovaccine
Cell Reports Medicine,
Год журнала:
2024,
Номер
unknown, С. 101877 - 101877
Опубликована: Дек. 1, 2024
Язык: Английский
Adipocyte‐Targeted Nanotechnology and Cell‐Based Therapy for Obesity Treatment
ChemMedChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 11, 2024
Obesity
is
a
critical
risk
factor
for
the
development
of
metabolic
diseases
and
often
associated
with
dysfunctional
adipocytes.
Prevalent
treatments
such
as
lifestyle
intervention,
pharmacotherapy,
bariatric
surgery
are
accompanied
by
adverse
side
effects
poor
patient
compliance.
Nanotechnology
cell-based
therapy
offer
innovative
approaches
targeted
obesity
treatments,
they
can
directly
target
adipocytes,
regulate
lipid
metabolism,
minimize
off-target
effects.
Here,
we
provide
an
overview
intricate
relationship
between
adipocytes
obesity,
highlighting
potential
nanotechnology
in
treatment.
Additionally,
discuss
advancements
adipose-derived
mesenchymal
stem
cells
(ADMSCs)
progression,
including
latest
challenges
considerations
developing
adipose-targeted
obesity.
The
objective
to
perspective
on
design
treating
related
comorbidities.
Язык: Английский