Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Chemical Society Reviews, Год журнала: 2022, Номер 51(15), С. 6307 - 6416

Опубликована: Янв. 1, 2022

This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.

Язык: Английский

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Calcium carbonate: controlled synthesis, surface functionalization, and nanostructured materials

Chemical Society Reviews, Год журнала: 2022, Номер 51(18), С. 7883 - 7943

Опубликована: Янв. 1, 2022

Calcium carbonate (CaCO3) is an important inorganic mineral in biological and geological systems. Traditionally, it widely used plastics, papermaking, ink, building materials, textiles, cosmetics, food. Over the last decade, there has been rapid development controlled synthesis surface modification of CaCO3, stabilization amorphous CaCO3 (ACC), CaCO3-based nanostructured materials. In this review, first examined, including Ca2+-CO32- systems, solid-liquid-gas carbonation, water-in-oil reverse emulsions, biomineralization. Advancing insights into nucleation crystallization have led to efficient routes towards with specific sizes, morphologies, polymorphs. Recently-developed methods include organic modifications, as well intensified reactions. The resultant can then be further engineered via template-induced biomineralization layer-by-layer assembly porous, hollow, or core-shell organic-inorganic nanocomposites. introduction materials a significant improvement mechanical, optical, magnetic, catalytic properties such showing great potential for use biomaterials biomedicine, environmental remediation, energy production storage. influences that preparation conditions additives on ACC are also discussed. Studies indicate construct environmentally-friendly hybrid films, supramolecular hydrogels, drug vehicles. Finally, existing challenges future directions functionalization its expanding applications highlighted.

Язык: Английский

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Emerging porous organic polymers for biomedical applications

Chemical Society Reviews, Год журнала: 2022, Номер 51(4), С. 1377 - 1414

Опубликована: Янв. 1, 2022

This review summarizes and discusses the recent progress in porous organic polymers for diverse biomedical applications such as drug delivery, biomacromolecule immobilization, phototherapy, biosensing, bioimaging, antibacterial applications.

Язык: Английский

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BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Advanced Materials, Год журнала: 2022, Номер 35(18)

Опубликована: Ноя. 18, 2022

Abstract The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, inspiring cutting‐edge work post‐functionalization highlighted. A brief overview assembly model BODIPY then provided: introduced as a promising building block for the formation single‐ multicomponent self‐assembled systems, including nanostructures suitable aqueous environments, thereby showing great development potential supramolecular applications. frontier progress biomedical application thereafter described, supported by examples frontiers applications BODIPY‐containing smart materials: it mainly involves materials based on blocks their assemblies fluorescence bioimaging, photoacoustic imaging, disease treatment photodynamic therapy, photothermal immunotherapy. Lastly, not only current status family field but also challenges worth considering summarized. At same time, insights into future prospects biomedically applicable provided.

Язык: Английский

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Synergistic Reinforcing of Immunogenic Cell Death and Transforming Tumor‐Associated Macrophages Via a Multifunctional Cascade Bioreactor for Optimizing Cancer Immunotherapy

Advanced Materials, Год журнала: 2022, Номер 34(51)

Опубликована: Окт. 17, 2022

Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct a tumor microenvironment and activate antitumor immunity. This study proposes two-way enhancement of ICD based on CaO2 @CuS-MnO2 @HA (CCMH) nanocomposite to overcome the insufficient damage-associated molecular patterns (DAMPs) conventional ICD-inducers. The near-infrared (NIR) irradiation (1064 nm) CuS nanoparticles generates 1 O2 through photodynamic therapy (PDT) trigger ICD, also damages Ca2+ buffer function mitochondria. Additionally, react with H2 O produce large amount , which respectively lead enhanced PDT overload during mitochondrial damage, thereby triggering robust activation. Moreover, oxidative-damaged DNA, induced by released from cells, reprograms immunosuppressive transforming tumor-associated macrophages M1 subphenotype. shows that CCMH NIR-II elicit adequate DAMPs an active tumor-immune for both 4T1 CT26 models. Combining this method immune checkpoint blockade realize improved immunotherapy efficacy long-term protection effect body.

Язык: Английский

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A Tumor‐Microenvironment‐Responsive Nanocomposite for Hydrogen Sulfide Gas and Trimodal‐Enhanced Enzyme Dynamic Therapy

Advanced Materials, Год журнала: 2021, Номер 33(30)

Опубликована: Июнь 17, 2021

Recently, enzyme dynamic therapy (EDT) has drawn much attention as a new type of therapy. However, the selection suitable nanocarriers to deliver chloroperoxidase (CPO) and enhancement level hydrogen peroxide (H

Язык: Английский

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A Ferrocene‐Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis

Small, Год журнала: 2021, Номер 17(32)

Опубликована: Июль 3, 2021

Chemodynamic therapy (CDT), which induces cell death by decomposing high levels of H2 O2 in tumor cells into highly toxic ·OH, is recognized as a promising antineoplastic approach. However, current CDT approaches are often restricted the controlled and upregulated cellular antioxidant defense. To enhance ·OH-induced damage CDT, covalent organic framework (COF)-based, ferrocene (Fc)- glutathione peroxidase 4 (GPX4) inhibitor-loaded nanodrug, RSL3@COF-Fc (2b), fabricated. The obtained 2b not only promotes situ Fenton-like reactions to trigger ·OH production cells, but also attenuates repair mechanisms under oxidative stress via irreversible GPX4 inhibition. As result, these two synergistically result massive lipid peroxide accumulation, subsequent damage, ultimately ferroptosis, while being limited intracellular glutathione. It believed that this research provides paradigm for enhancing reactive oxygen species-mediated oncotherapy through redox dyshomeostasis may provide new insights developing COF-based nanomedicine.

Язык: Английский

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Construction of Covalent Organic Frameworks via Multicomponent Reactions

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(3), С. 1475 - 1496

Опубликована: Янв. 16, 2023

Multicomponent reactions (MCRs) combine at least three reactants to afford the desired product in a highly atom-economic way and are therefore viewed as efficient one-pot combinatorial synthesis tools allowing one significantly boost molecular complexity diversity. Nowadays, MCRs no longer confined organic have found applications materials chemistry. In particular, can be used prepare covalent frameworks (COFs), which crystalline porous assembled from monomers exhibit broad range of properties applications. This synthetic approach retains advantages small-molecule MCRs, not only strengthening skeletal robustness COFs, but also providing additional driving forces for their crystallization, has been series robust COFs with diverse The present perspective article provides general background discusses types employed COF date, addresses related critical challenges future perspectives inspire MCR-based design new promote further progress this emerging field.

Язык: Английский

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Post-synthetic modifications in porous organic polymers for biomedical and related applications

Chemical Society Reviews, Год журнала: 2021, Номер 51(1), С. 43 - 56

Опубликована: Дек. 3, 2021

Porous organic polymers (POPs) are prepared by crosslinked polymerization of multidimensional rigid aromatic building blocks followed PSM depending on the application.

Язык: Английский

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Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy

Nano-Micro Letters, Год журнала: 2022, Номер 14(1)

Опубликована: Июль 18, 2022

As the indispensable second cellular messenger, calcium signaling is involved in regulation of almost all physiological processes by activating specific target proteins. The importance ions (Ca

Язык: Английский

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