Therapeutic strategies against bacterial biofilms

Fundamental Research, Год журнала: 2021, Номер 1(2), С. 193 - 212

Опубликована: Фев. 21, 2021

The emergence of multi-drug resistance makes bacterial infection a major threat to public health and economy. formation biofilms is one the main reasons resistance. complexity chemical composition physical structure elimination mature difficult problem. highly antibiotic resistant property urgently calls for potent antimicrobial agents novel antibiofilm strategies. Researchers have made lot efforts in this field. Here we review current strategies eliminate progress related drug delivery nanosystems, with aim inspiring researchers design new systems.

Язык: Английский

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Smart micro- and nanorobots for water purification

Nature Reviews Bioengineering, Год журнала: 2023, Номер 1(4), С. 236 - 251

Опубликована: Фев. 6, 2023

Язык: Английский

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Lighting up Micro-/Nanorobots with Fluorescence

Chemical Reviews, Год журнала: 2022, Номер 123(7), С. 3944 - 3975

Опубликована: Сен. 15, 2022

Micro-/nanorobots (MNRs) can be autonomously propelled on demand in complex biological environments and thus may bring revolutionary changes to biomedicines. Fluorescence has been widely used real-time imaging, chemo-/biosensing, photo-(chemo-) therapy. The integration of MNRs with fluorescence generates fluorescent unique advantages optical trackability, on-the-fly environmental sensitivity, targeting chemo-/photon-induced cytotoxicity. This review provides an up-to-date overview MNRs. After the highlighted elucidation about various propulsion mechanisms introductory information emphasis materials, we systematically illustrate design preparation strategies integrate substances their biomedical applications imaging-guided drug delivery, intelligent sensing In end, summarize main challenges provide outlook future directions work is expected attract inspire researchers from different communities advance creation practical application a broad horizon.

Язык: Английский

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Bioinspired claw-engaged and biolubricated swimming microrobots creating active retention in blood vessels

Science Advances, Год журнала: 2023, Номер 9(18)

Опубликована: Май 5, 2023

Swimming microrobots guided in the circulation system offer considerable promise precision medicine but currently suffer from problems such as limited adhesion to blood vessels, intensive flow, and immune clearance-all reducing targeted interaction. A swimming microrobot design with clawed geometry, a red cell (RBC) membrane-camouflaged surface, magnetically actuated retention is discussed, allowing better navigation inspired by tardigrade's mechanical claw engagement, coupled an RBC membrane coating, minimize flow impact. Using clinical intravascular optical coherence tomography vivo, microrobots' activity dynamics rabbit jugular vein was monitored, illustrating very effective magnetic propulsion, even against of ~2.1 cm/s, comparable characteristics. The equivalent friction coefficient elevated ~24-fold, compared microspheres, achieving active at 3.2 for >36 hours, showing across biomedical applications.

Язык: Английский

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Magnetic Nanorobots as Maneuverable Immunoassay Probes for Automated and Efficient Enzyme Linked Immunosorbent Assay

ACS Nano, Год журнала: 2022, Номер 16(1), С. 180 - 191

Опубликована: Янв. 11, 2022

As a typical, classical, but powerful biochemical sensing technology in analytical chemistry, enzyme-linked immunosorbent assay (ELISA) shows excellence and wide practicability for quantifying analytes of ultralow concentration. However, long incubation time burdensome laborious multistep washing processes make it inefficient labor-intensive conventional ELISA. Here, we propose rod-like magnetically driven nanorobots (MNRs) use as maneuverable immunoassay probes that facilitate strategy an automated highly efficient ELISA analysis, termed enabled (nR-ELISA). To prepare the MNRs, self-assembled chains Fe3O4 magnetic particles are chemically coated with thin layer rigid silica oxide (SiO2), onto which capture antibody (Ab1) is grafted to further achieve (MNR-Ab1s). We investigate fluid velocity distribution around MNRs at microscale using numerical simulation empirically identify mixing efficiency actively rotating MNRs. automate analysis process, design fabricate by 3-D printing detection unit consisting three function wells. The MNR-Ab1s can be steered into different wells required reaction or wishing process. enhance binding efficacy target greatly decrease time. integrated nR-ELISA system significantly reduce time, more importantly during process manpower input minimized. Our field generated Helmholtz coils demonstrates our approach scaled up, proves feasibility current construct high throughput instrument. This work taking micro/nanobots active automatic not only holds great potential point-of-care testing (POCT) future also extends practical applications self-propelled micro/nanorobots chemistry.

Язык: Английский

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Stimuli-triggered multilayer films in response to temperature and ionic strength changes for controlled favipiravir drug release

Biomedical Materials, Год журнала: 2024, Номер 19(3), С. 035004 - 035004

Опубликована: Фев. 16, 2024

The block copolymer micelles and natural biopolymers were utilized to form layer-by-layer (LbL) films via electrostatic interaction, which able effectively load controllably release favipiravir, a potential drug for the treatment of coronavirus epidemic. LbL demonstrated reversible swelling/shrinking behavior along with manipulation temperature, could also maintain integrity in structure morphology. Due dehydration environmentally responsive building blocks, rate from was decelerated by elevating environmental temperature ionic strength. In addition, pulsed favipiravir observed multilayer under trigger ensured precise control content therapeutic reagents at desired time point. nanoparticle-based be used on-demand

Язык: Английский

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Drug-Free Antimicrobial Nanomotor for Precise Treatment of Multidrug-Resistant Bacterial Infections

Nano Letters, Год журнала: 2023, Номер 23(9), С. 3929 - 3938

Опубликована: Апрель 27, 2023

Manufacturing heteronanostructures with specific physicochemical characteristics and tightly controllable designs is very appealing. Herein, we reported NIR-II light-driven dual plasmonic (AuNR-SiO2-Cu7S4) antimicrobial nanomotors an intended Janus configuration through the overgrowth of copper-rich Cu7S4 nanocrystals at only one high-curvature site Au nanorods (Au NRs). These were applied for photoacoustic imaging (PAI)-guided synergistic photothermal photocatalytic treatment bacterial infections. Both performance activity are dramatically improved owing to strong plasmon coupling between NRs component enhanced energy transfer. The motion behavior promotes transdermal penetration enhances matter–bacteria interaction. More importantly, directional navigation could be synchronously driven by light. marriage active antibacterial resulted in expected good effects abscess infection mouse model.

Язык: Английский

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Chemical multiscale robotics for bacterial biofilm treatment

Chemical Society Reviews, Год журнала: 2024, Номер 53(5), С. 2284 - 2299

Опубликована: Янв. 1, 2024

A biofilm constitutes a bacterial community encased in sticky matrix of extracellular polymeric substances. These intricate microbial communities adhere to various host surfaces such as hard and soft tissues well indwelling medical devices. aggregates form robust substances (EPSs), leading the majority human infections. Such infections tend exhibit high resistance treatment, often progressing into chronic states. The EPS protects bacteria from hostile environment prevents penetration antibacterial agents. Modern robots at nano, micro, millimeter scales are highly attractive candidates for biomedical applications due their diverse functionalities, navigating confined spaces targeted multitasking. In this tutorial review, we describe key milestones strategies developed removal eradication biofilms using different sizes shapes. It can be seen that useful effective tools treating biofilms, thus preventing persistent infections, loss costly implanted devices, additional costs associated with hospitalization therapies.

Язык: Английский

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Silver/jellyfish-like mesoporous polydopamine nanomotor with concentration-dependent synergistic antibacterial activity

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159367 - 159367

Опубликована: Янв. 1, 2025

Язык: Английский

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Endoscope-assisted magnetic helical micromachine delivery for biofilm eradication in tympanostomy tube

Science Advances, Год журнала: 2022, Номер 8(40)

Опубликована: Окт. 7, 2022

Occlusion of the T-tube (tympanostomy tube) is a common postoperative sequela related to bacterial biofilms. Confronting biofilm-related infections T-tubes, maneuverable and effective treatments are still challenging presently. Here, we propose an endoscopy-assisted treatment procedure based on wobbling Fe2O3 helical micromachine (HMM) with peroxidase-mimicking activity. Different from ideal corkscrew motion, HMM applies motion in tube, inducing stronger mechanical force fluid convections, which not only damages biofilm occlusion into debris quickly but also enhances catalytic generation diffusion reactive oxygen species (ROS) for killing bacteria cells. Moreover, procedure, integrated delivery, actuation, retrieval HMM, was validated implanted human cadaver ex vivo. It enables visual operation ease gentle tympanic membrane ossicles, promising clinical application.

Язык: Английский

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