Advanced Functional Materials,
Год журнала:
2024,
Номер
34(27)
Опубликована: Март 5, 2024
Abstract
Conventional
magnetophoresis
techniques
for
manipulating
biocarriers
and
cells
predominantly
rely
on
large‐scale
electromagnetic
systems,
which
is
a
major
obstacle
to
the
development
of
portable
miniaturized
cell‐on‐chip
platforms.
Herein,
novel
magnetic
engineering
approach
by
tailoring
nanoscale
notch
disk
micromagnet
using
two‐step
optical
thermal
lithography
developed.
Versatile
manipulations
are
demonstrated,
such
as
separation
trapping,
carriers
mediating
changes
in
domain
structure
discontinuous
movement
energy
wells
around
circumferential
edge
caused
locally
fabricated
nano‐notch
low
field
system.
The
motion
well
regulated
configuration
strength
frequency
field,
accompanying
jump
carriers.
proposed
concepts
demonstrate
that
multiple
can
be
manipulated
sorted
optimized
multi‐notch
gates
magnetophoretic
This
highlights
potential
developing
cost‐effective
point‐of‐care
testing
lab‐on‐chip
systems
various
single‐cell‐level
diagnoses
analyses.
Despite
significant
advancements
in
medical
technology,
cancer
remains
the
world's
second‐leading
cause
of
death,
largely
attributed
to
late‐stage
diagnoses.
While
traditional
detection
methodologies
offer
foundational
insights,
they
often
lack
specificity,
affordability,
and
sensitivity
for
early‐stage
identification.
In
this
context,
development
biosensors
offers
a
distinct
possibility
precise
rapid
identification
biomarkers.
Carbon
nanomaterials,
including
graphene,
carbon
nitride,
quantum
dots,
other
carbon‐based
nanostructures,
are
highly
promising
detection.
Their
simplicity,
high
sensitivity,
cost‐effectiveness
contribute
their
potential
field.
This
review
aims
elucidate
emerging
carbon‐nanomaterial‐based
early
diagnosis.
The
relevance
various
biosensor
mechanisms
performance
physicochemical
properties
nanomaterials
is
discussed
depth,
focusing
on
demonstrating
broad
creating
biosensors.
Diverse
techniques,
such
as
electrochemical,
fluorescence,
surface
plasmon
resonance,
electrochemiluminescence,
quartz
crystal
microbalance,
emphasized
At
last,
summary
existing
challenges
future
outlook
field
elaborated.
Acta Pharmaceutica Sinica B,
Год журнала:
2022,
Номер
13(2), С. 517 - 541
Опубликована: Окт. 13, 2022
Attributed
to
the
miniaturized
body
size
and
active
mobility,
micro-
nanomotors
(MNMs)
have
demonstrated
tremendous
potential
for
medical
applications.
However,
from
bench
bedside,
massive
efforts
are
needed
address
critical
issues,
such
as
cost-effective
fabrication,
on-demand
integration
of
multiple
functions,
biocompatibility,
biodegradability,
controlled
propulsion
in
vivo
navigation.
Herein,
we
summarize
advances
biomedical
MNMs
reported
past
two
decades,
with
particular
emphasis
on
design,
propulsion,
navigation,
abilities
biological
barriers
penetration,
biosensing,
diagnosis,
minimally
invasive
surgery
targeted
cargo
delivery.
Future
perspectives
challenges
discussed
well.
This
review
can
lay
foundation
future
direction
MNMs,
pushing
one
step
forward
road
achieving
practical
theranostics
using
MNMs.
Nano-Micro Letters,
Год журнала:
2022,
Номер
15(1)
Опубликована: Дек. 29, 2022
Due
to
their
tiny
size,
autonomous
motion
and
functionalize
modifications,
micro/nanomotors
have
shown
great
potential
for
environmental
remediation,
biomedicine
micro/nano-engineering.
One-dimensional
(1D)
combine
the
characteristics
of
anisotropy
large
aspect
ratio
1D
materials
with
advantages
functionalization
revolutionary
applications.
In
this
review,
we
discuss
current
research
progress
on
micro/nanomotors,
including
fabrication
methods,
driving
mechanisms,
recent
advances
in
remediation
biomedical
applications,
as
well
challenges
possible
solutions.
With
continuous
attention
innovation,
advancement
will
pave
way
continued
development
micro/nanomotor
field.
Materials & Design,
Год журнала:
2023,
Номер
227, С. 111735 - 111735
Опубликована: Фев. 13, 2023
Microrobots
have
received
extensive
attention
in
the
past
few
decades,
and
in-depth
research
of
micro-nano
processing
technology
materials
has
promoted
further
development
microrobots.
Researchers
successfully
achieved
use
chemical
fuels,
electric,
sound,
magnetic
fields
to
promote
movement
Among
many
power
sources,
attracted
wide
because
their
advantages
including
remote
wireless
operation
harmlessness
human
body.
After
decades
development,
magnetically
driven
microrobots
been
extensively
studied
cargo
transportation,
cell
manipulation,
toxic
substance
removal,
micromanipulation.
This
article
first
summarizes
driving
methods
recent
years,
then
for
manufacturing
microrobots,
shapes
typical
spiral,
spherical,
linear
structures.
that,
are
sorted
out,
application
magnetic-driven
biomedicine
other
years
is
summarized.
Finally,
prospects
discussed.
ACS Nano,
Год журнала:
2023,
Номер
17(10), С. 8899 - 8917
Опубликована: Май 4, 2023
With
the
development
of
advanced
biomedical
theragnosis
and
bioengineering
tools,
smart
soft
responsive
microstructures
nanostructures
have
emerged.
These
structures
can
transform
their
body
shape
on
demand
convert
external
power
into
mechanical
actions.
Here,
we
survey
key
advances
in
design
polymer–particle
nanocomposites
that
led
to
shape-morphing
microscale
robotic
devices.
We
overview
technological
roadmap
field
highlight
emerging
opportunities
programming
magnetically
nanomaterials
polymeric
matrixes,
as
magnetic
materials
offer
a
rich
spectrum
properties
be
encoded
with
various
magnetization
information.
The
use
fields
tether-free
control
easily
penetrate
biological
tissues.
nanotechnology
manufacturing
techniques,
microrobotic
devices
realized
desired
reconfigurability.
emphasize
future
fabrication
techniques
will
bridging
gaps
between
integrating
sophisticated
functionalities
nanoscale
reducing
complexity
footprints
intelligent
robots.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(15)
Опубликована: Янв. 25, 2023
Abstract
Untethered
mobile
micro‐/nanomotors
(MNMs),
as
newly‐emerging
attractive
and
versatile
nanotechnologies,
are
expected
to
be
the
next‐generation
disease
treatment
tools,
for
breaking
through
limitations
of
conventional
passive
drug
delivery
manner.
However,
advances
in
these
fascinating
platforms
have
been
hampered
by
complexity
biological
environment
particularity
microenvironment.
Consequently,
specific
design
strategies
clinical
imaging
techniques
essential
ensure
high‐efficiency
biomedical
MNMs
on
actuation,
targeting,
localization,
therapy
when
performing
assigned
vivo
tasks.
This
review
thus
comprehensively
addresses
three
aspects
MNMs,
including
design,
imaging,
treatment,
highlighting
intelligent
with
biomimetic
functionality
chemotactic
capability,
emphasizing
applicability
different
techniques,
focusing
various
proof‐of‐concept
studies
based
physiological
characteristics
major
diseases.
In
addition,
key
challenges
current
addressed,
which
may
inspire
future
research
facilitate
translation
toward
treatment.
Advanced Materials,
Год журнала:
2024,
Номер
36(23)
Опубликована: Фев. 21, 2024
Medical
microrobotics
is
an
emerging
field
to
revolutionize
clinical
applications
in
diagnostics
and
therapeutics
of
various
diseases.
On
the
other
hand,
mobile
has
important
obstacles
pass
before
translation.
This
article
focuses
on
these
challenges
provides
a
roadmap
medical
microrobots
enable
their
use.
From
concept
"magic
bullet"
physicochemical
interactions
complex
biological
environments
applications,
there
are
several
translational
steps
consider.
Clinical
translation
only
possible
with
close
collaboration
between
experts
researchers
address
technical
microfabrication,
safety,
imaging.
The
application
potential
can
be
materialized
by
designing
that
solve
current
main
challenges,
such
as
actuation
limitations,
material
stability,
imaging
constraints.
strengths
weaknesses
progress
discussed
for
near
future
outlined.
