Green Synthesis and Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Given
the
significance
of
oxacyclic
frameworks
in
molecular
scaffolds
and
drug
discovery,
it
is
intriguing
to
precisely
construct
manipulate
such
ring
systems
chemical
research.
In
this
area,
intermolecular,
multicomponent
cyclization
for
synthesis
diversely
substituted
seven-membered
oxacycles
under
simple
conditions
still
a
challenge.
Here,
we
report
dual
photoredox/Brønsted
acid
relay
catalytic
strategy
situ
generation
ortho-quinone
methides
subsequent
(4+3)
with
2-indolylalcohols.
one-pot
reaction,
two
C-C
one
C-O
bonds
are
formed,
providing
de
novo
access
various
biologically
important
indole-fused,
oxygen-containing
heterocycles.
By
virtue
chiral
phosphoric
acid,
an
asymmetric
version
can
also
be
achieved
good
excellent
levels
enantioselectivity
(up
96:4
er).
Chemical Reviews,
Год журнала:
2022,
Номер
122(24), С. 17479 - 17646
Опубликована: Окт. 14, 2022
Alkenes
and
their
derivatives
are
featured
widely
in
a
variety
of
natural
products,
pharmaceuticals,
advanced
materials.
Significant
efforts
have
been
made
toward
the
development
new
practical
methods
to
access
this
important
class
compounds
by
selectively
activating
alkenyl
C(sp2)–H
bonds
recent
years.
In
comprehensive
review,
we
describe
state-of-the-art
strategies
for
direct
functionalization
sp2
C–H
C–F
until
June
2022.
Moreover,
metal-free,
photoredox,
electrochemical
also
covered.
For
clarity,
review
has
divided
into
two
parts;
first
part
focuses
on
currently
available
using
different
alkene
as
starting
materials,
second
describes
bond
easily
accessible
gem-difluoroalkenes
material.
This
includes
scope,
limitations,
mechanistic
studies,
stereoselective
control
(using
directing
groups
well
metal-migration
strategies),
applications
complex
molecule
synthesis
where
appropriate.
Overall,
aims
document
considerable
advancements,
current
status,
emerging
work
critically
summarizing
contributions
researchers
working
fascinating
area
is
expected
stimulate
novel,
innovative,
broadly
applicable
functionalizations
coming
Chemical Reviews,
Год журнала:
2023,
Номер
123(19), С. 11269 - 11335
Опубликована: Сен. 26, 2023
Late-stage
functionalization
(LSF)
constitutes
a
powerful
strategy
for
the
assembly
or
diversification
of
novel
molecular
entities
with
improved
physicochemical
biological
activities.
LSF
can
thus
greatly
accelerate
development
medicinally
relevant
compounds,
crop
protecting
agents,
and
functional
materials.
Electrochemical
synthesis
has
emerged
as
an
environmentally
friendly
platform
transformation
organic
compounds.
Over
past
decade,
electrochemical
late-stage
(eLSF)
gained
major
momentum,
which
is
summarized
herein
up
to
February
2023.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
60(12), С. 6419 - 6424
Опубликована: Янв. 20, 2021
Abstract
Electrooxidative
annulations
involving
mild
transition
metal‐catalyzed
C−H
activation
have
emerged
as
a
transformative
strategy
for
the
rapid
construction
of
five‐
and
six‐membered
heterocycles.
In
contrast,
we
herein
describe
first
electrochemical
[5+2]
cycloadditions
to
assemble
valuable
seven‐membered
benzoxepine
skeletons
by
C−H/O−H
activation.
The
efficient
alkyne
annulation
featured
ample
substrate
scope,
using
electricity
only
oxidant.
Mechanistic
studies
provided
strong
support
rhodium(III/I)
regime,
benzoxepine‐coordinated
rhodium(I)
sandwich
complex
catalyst
resting
state,
which
was
re‐oxidized
rhodium(III)
anodic
oxidation.
ACS Catalysis,
Год журнала:
2021,
Номер
11(11), С. 6590 - 6595
Опубликована: Май 20, 2021
Herein,
we
describe
the
development
of
a
Rh-catalyzed
C–H
acyloxylation
under
mild
electrolytic
conditions.
Anodic
oxidation
key
rhodacyclic
carboxylate
intermediate
was
found
to
enable
product-releasing
C–O
bond-forming
reductive
elimination
process.
An
accumulation
near
electrode
surface
rationalized
further
induce
desired
bond
formation,
allowing
an
ambient
catalytic
oxygenation
using
stoichiometric
amounts
readily
accessible
carboxylic
acid
coupling
partners.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(20)
Опубликована: Фев. 16, 2022
While
electrochemical
ortho-selective
C-H
activations
are
well
established,
distal
continue
to
be
underdeveloped.
In
contrast,
we
herein
describe
the
meta-C-H
functionalization.
The
remote
bromination
was
accomplished
in
an
undivided
cell
by
RuCl
Green Chemistry,
Год журнала:
2022,
Номер
24(12), С. 4772 - 4777
Опубликована: Янв. 1, 2022
An
electrochemical
protocol
for
the
selective
oxidation
of
sulfides
to
sulfoxides
has
been
developed
in
which
NaCl
plays
a
dual
role:
(1)
as
an
electrolyte
transformations
and
(2)
redox
mediator
avoid
sensitive
functional
groups.
ACS Omega,
Год журнала:
2023,
Номер
8(7), С. 6175 - 6217
Опубликована: Фев. 1, 2023
Numerous
applications
in
the
realm
of
biological
exploration
and
drug
synthesis
can
be
found
heterocyclic
chemistry,
which
is
a
vast
subject.
Many
efforts
have
been
developed
to
further
improve
reaction
conditions
access
this
interesting
family
prevent
employing
hazardous
ingredients.
In
instance,
it
has
stated
that
green
environmentally
friendly
manufacturing
methodologies
introduced
create
N-,
S-,
O-heterocycles.
It
appears
one
most
promising
methods
these
types
compounds
avoiding
use
stoichiometric
amounts
oxidizing/reducing
species
or
precious
metal
catalysts,
only
catalytic
are
sufficient,
represent
an
ideal
way
contributing
toward
resource
economy.
Thus,
renewable
electricity
provides
clean
electrons
(oxidant/reductant)
initiate
cascade
via
producing
reactive
intermediates
facilitate
building
new
bonds
for
valuable
chemical
transformations.
Moreover,
electrochemical
activation
using
metals
as
mediators
identified
more
efficient
strategy
selective
functionalization.
indirect
electrolysis
makes
potential
range
practical,
less
side
reactions
occur.
The
latest
developments
electrolytic
O-heterocycles
main
topic
mini
review,
was
documented
over
last
five
years.
Advanced Materials,
Год журнала:
2023,
Номер
35(49)
Опубликована: Март 25, 2023
Polycyclic
aromatic
hydrocarbons
(PAHs)
have
surfaced
as
increasingly
viable
components
in
optoelectronics
and
material
sciences.
The
development
of
highly
efficient
atom-economic
tools
to
prepare
PAHs
under
exceedingly
mild
conditions
constitutes
a
long-term
goal.
Traditional
syntheses
largely
relied
on
multistep
approaches
or
the
conventional
Scholl
reaction.
However,
reactions
are
inefficient
with
electron-deficient
substrates,
require
stoichiometric
chemical
oxidants,
typically
occur
presence
strong
acid.
In
sharp
contrast,
electrochemistry
has
gained
considerable
momentum
during
past
decade
an
alternative
for
facile
straightforward
assembly,
generally
via
electro-oxidative
dehydrogenative
annulation,
releasing
molecular
hydrogen
sole
byproduct
by
evolution
This
review
provides
overview
recent
significant
advances
field
electrochemical
various
until
January
2023.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(18), С. 5232 - 5277
Опубликована: Янв. 1, 2024
This
review
describes
recent
advances
in
the
generation
of
aryl
radicals
using
light
and
electricity.
Such
modern
techniques
allow
for
efficient
energy
resource
utilization,
thus
providing
more
sustainable
radical
arylation
methods.
