Advanced Materials,
Год журнала:
2022,
Номер
34(32)
Опубликована: Июнь 10, 2022
Macrocyclic
delivery
and
therapeutics
are
two
significant
topics
in
supramolecular
biomedicine.
The
functional
integration
of
these
would
open
new
avenues
for
treating
diseases
synergistically.
However,
individual
have
only
been
occasionally
merged,
probably
because
the
lack
functionalized
design
macrocyclic
host
efficient
recognition
between
guest
drugs.
Herein,
a
"drug-in-drug"
strategy
is
proposed,
which
an
active
drug
encapsulated
by
macrocycle
possessing
therapeutic
activity
to
form
multifunctional
pharmaceutical
ingredient.
As
proof-of-concept,
complex
hydroxychloroquine
(HCQ)
with
sulfonated
azocalix[4]arene
(HCQ@SAC4A)
prepared
treat
rheumatoid
arthritis
(RA)
combined
fashion.
SAC4A
agent
that
exhibits
scavenging
capacity
reactive
oxygen
species
exerts
anti-inflammatory
effect.
It
also
hypoxia-responsive
carrier
can
deliver
HCQ
directly
inflammatory
articular
cavity.
Consequently,
HCQ@SAC4A
achieves
synergistic
effect
on
both
inflamed
RAW
264.7
cells
RA
rats.
This
attributed
temporal
spatial
consistency
ingredients
complex.
paradigm
combinational
therapy,
drug-in-drug
advances
easy
preparation,
mix-and-match
combination,
precise
ratiometric
control.
Advanced Materials,
Год журнала:
2021,
Номер
34(6)
Опубликована: Окт. 25, 2021
Abstract
Nanomedicines
have
the
potential
to
provide
advanced
therapeutic
strategies
in
combating
tumors.
Polymer‐prodrug‐based
nanomedicines
are
particularly
attractive
cancer
therapies
owing
maximum
drug
loading,
prolonged
blood
circulation,
and
reduced
premature
leakage
side
effects
comparison
with
conventional
nanomaterials.
However,
difficulty
precisely
tuning
composition
loading
of
polymer–drug
conjugates
leads
batch‐to‐batch
variations
prodrugs,
thus
significantly
restricting
their
clinical
translation.
Polyprodrug
inherit
numerous
intrinsic
advantages
exhibit
well‐controlled
via
direct
polymerization
monomers,
representing
a
promising
nanomedicine
for
tumor
therapies.
In
this
review,
recent
advances
development
polyprodrug
summarized
elimination.
Various
types
corresponding
properties
first
summarized.
The
unique
key
roles
various
further
highlighted.
Finally,
current
challenges
perspectives
on
future
research
discussed.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(27)
Опубликована: Апрель 5, 2022
Supramolecular
nanomedicines
have
shown
great
merits
in
cancer
therapy,
but
their
clinical
translation
is
hampered
by
monotonous
therapeutic
modality
and
unsatisfactory
antitumor
performance.
Herein,
a
hybrid
supramolecular
polymeric
nanomedicine
(SNPs)
developed
based
on
β-cyclodextrin/camptothecin
(CPT)
host-guest
molecular
recognition
iron-carboxylate
coordination.
Iron
ions
stabilizing
SNPs
catalyze
the
conversion
of
intracellular
hydrogen
peroxide
into
highly
toxic
hydroxyl
radical
through
Fenton
reaction,
which
further
cleaves
thioketal
linker
monomer
to
release
potent
CPT,
thus
amplifying
efficacy
combining
chemodynamic
therapy
chemotherapy.
The
combination
stimulates
immunity
promotes
intratumoral
infiltration
cytotoxic
T
lymphocytes
triggering
immunogenic
cell
death.
In
synergy
with
PD-L1
checkpoint
blockade,
enables
enhanced
immune
long-term
tumor
remission.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(38)
Опубликована: Авг. 1, 2022
Abstract
The
intelligent
nanomachine
usually
has
a
control
center
to
carry
out
self‐regulation.
Unfortunately,
most
of
the
nanomaterials
for
chemodynamic
therapy
(CDT)
do
not
have
such
sense
and
process
chemical
or
biological
signals,
which
greatly
weakens
selectivity
efficiency
CDT.
To
address
this
problem,
here
an
was
constructed
with
DNAzyme
logic
gate
as
center,
metal
organic
framework
actuator.
well‐designed
showed
enhanced
killing
effect
on
cancer
cells
but
posed
no
harm
normal
cells,
acquiring
better
than
clinical
chemotherapy
drugs
(doxorubicin
cisplatin).
best
our
knowledge,
is
first
reported
cell‐specific
CDT
by
guidance
gate.
Our
work
highlights
great
potential
DNAzymes
in
response
networks,
extends
implementation
nanomachines
precision
medicine.
Advanced Materials,
Год журнала:
2022,
Номер
34(32)
Опубликована: Июнь 10, 2022
Macrocyclic
delivery
and
therapeutics
are
two
significant
topics
in
supramolecular
biomedicine.
The
functional
integration
of
these
would
open
new
avenues
for
treating
diseases
synergistically.
However,
individual
have
only
been
occasionally
merged,
probably
because
the
lack
functionalized
design
macrocyclic
host
efficient
recognition
between
guest
drugs.
Herein,
a
"drug-in-drug"
strategy
is
proposed,
which
an
active
drug
encapsulated
by
macrocycle
possessing
therapeutic
activity
to
form
multifunctional
pharmaceutical
ingredient.
As
proof-of-concept,
complex
hydroxychloroquine
(HCQ)
with
sulfonated
azocalix[4]arene
(HCQ@SAC4A)
prepared
treat
rheumatoid
arthritis
(RA)
combined
fashion.
SAC4A
agent
that
exhibits
scavenging
capacity
reactive
oxygen
species
exerts
anti-inflammatory
effect.
It
also
hypoxia-responsive
carrier
can
deliver
HCQ
directly
inflammatory
articular
cavity.
Consequently,
HCQ@SAC4A
achieves
synergistic
effect
on
both
inflamed
RAW
264.7
cells
RA
rats.
This
attributed
temporal
spatial
consistency
ingredients
complex.
paradigm
combinational
therapy,
drug-in-drug
advances
easy
preparation,
mix-and-match
combination,
precise
ratiometric
control.
