Journal of Colloid and Interface Science, Год журнала: 2022, Номер 629, С. 379 - 390
Опубликована: Сен. 14, 2022
Язык: Английский
Advanced Materials, Год журнала: 2023, Номер 36(21)
Опубликована: Июль 21, 2023
Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward
Язык: Английский
Процитировано
100
Coordination Chemistry Reviews, Год журнала: 2023, Номер 481, С. 215051 - 215051
Опубликована: Фев. 1, 2023
Язык: Английский
Процитировано
59
Chemical Society Reviews, Год журнала: 2023, Номер 52(22), С. 7707 - 7736
Опубликована: Янв. 1, 2023
This review summarizes the strategies to engineer CDT nanocatalysts based on diverse nanocarriers, especially those with intrinsic therapeutic activities.
Язык: Английский
Процитировано
53
Advanced Materials, Год журнала: 2024, Номер 36(26)
Опубликована: Апрель 11, 2024
Drug delivery is a key component of nanomedicine, and conventional relies on the adsorption or encapsulation drug molecules to nanomaterial. Many vehicles contain metal ions, such as metal-organic frameworks, oxides, transition dichalcogenides, MXene, noble nanoparticles. These materials have high content pose potential long-term toxicity concerns leading difficulties for clinical approval. In this review, recent developments are summarized in use ligands coordination forming various nanomaterials soft materials. these cases, drug-to-metal ratio much higher than adsorption-based strategies. The divided into small-molecule drugs, nucleic acids, proteins. formed hybrid mainly include nanoparticles hydrogels, upon which targeting can be grafted improve efficacy further decrease toxicity. application addressing cancer, viral infection, bacterial infection inflammatory bowel disease, bone diseases reviewed. end, some future directions discussed from fundamental research, science, medicine.
Язык: Английский
Процитировано
29
BMEMat, Год журнала: 2024, Номер 2(2)
Опубликована: Янв. 12, 2024
Abstract Although immunotherapy has revolutionized cancer therapy by providing efficient tumor growth suppression, long‐term protection from recurrence as well minimized side effects, the low response rate significantly limits clinical application of in board types solid tumors. In order to improve therapeutic efficacy, conventional therapies including radiotherapy, chemotherapy, phototherapy and chemodynamic are employed combine with elicit stronger antitumor immune responses. Polymer nanomedicines frequently utilized synergistic other owing their tunable physiochemical properties, high drug loading capacity, ease modification toxicity. With elaborate design tailored polymer can enhance efficacy enhancing specificity, priming cells amplifying responses However, until now, there is no review solely dedicated comprehensive development polymer‐based platforms for combinational cancers. Herein, this paper summarizes latest advances design, fabrication traditional strategies photothermal therapy, photodynamic therapies. An outlook on trajectory potential challenges bridging gap between also discussed.
Язык: Английский
Процитировано
25
Chemical Science, Год журнала: 2024, Номер 15(6), С. 1966 - 2006
Опубликована: Янв. 1, 2024
Neoplasias pose a significant threat to aging society, underscoring the urgent need overcome limitations of traditional chemotherapy through pioneering strategies. Targeted drug delivery is an evolving frontier in cancer therapy, aiming enhance treatment efficacy while mitigating undesirable side effects. One promising avenue utilizes cell membrane receptors like folate receptor guide transporters precisely malignant cells. Based on cellular as hallmark, targeted nanocarriers and small molecule-drug conjugates have been developed that comprise different (bio) chemistries and/or mechanical properties with individual advantages challenges. Such modern folic acid-conjugated stimuli-responsive provide systemic controlled release, enabling reduced dosages, circumvention resistance, diminished adverse Since transporters' structure-based
Язык: Английский
Процитировано
22
Biomaterials, Год журнала: 2024, Номер 306, С. 122472 - 122472
Опубликована: Янв. 23, 2024
Язык: Английский
Процитировано
19
Advanced Science, Год журнала: 2024, Номер 11(20)
Опубликована: Март 17, 2024
Abstract Insufficient tumor immunogenicity and immune escape from tumors remain common problems in all immunotherapies. Recent studies have shown that pyroptosis, a form of programmed cell death is accompanied by checkpoint inhibitors, can induce effective immunogenic long‐term activation. Therapeutic strategies to jointly pyroptosis reverse immunosuppressive microenvironments are promising for cancer immunotherapy. In this regard, dual‐responsive supramolecular polymeric nanomedicine (NCSNPs) self‐cascade amplify the benefits immunotherapy designed. The NCSNPs formulated β‐cyclodextrin coupling nitric oxide (NO) donor, activator, NLG919, an indoleamine 2,3‐dioxygenase (IDO) inhibitor, self‐assembled through host–guest molecular recognition hydrophobic interaction obtain nanoparticles. possess excellent accumulation bioavailability attributed ingenious engineering. study not only confirms occurrence NO‐triggered first time but also reverses microenvironment sites via IDO inhibitor enhancing infiltration cytotoxic T lymphocytes, achieve remarkable inhibition proliferation. Thus, provides novel strategy
Язык: Английский
Процитировано
19
Coordination Chemistry Reviews, Год журнала: 2022, Номер 479, С. 215004 - 215004
Опубликована: Дек. 31, 2022
Язык: Английский
Процитировано
59
Journal of the American Chemical Society, Год журнала: 2023, Номер 145(34), С. 18789 - 18799
Опубликована: Авг. 3, 2023
Despite the tremendous breakthrough of immunotherapy, low response rate and resistance immune checkpoint inhibitors (ICIs) toward solid tumors occur frequently. A highly hypoxic tumor microenvironment (TME) provides cells with high concentrations HIF-1α polyamines to evade cell destruction. Reprogramming an immunogenic TME has exhibited a brilliant future boost immunotherapeutic performances. Herein, supramolecular nanomedicine (TAPP) is developed on basis host-guest molecular recognition metal coordination, showing capability remodel immunosuppressive TME. Tamoxifen (Tmx) Fe3+ are encapsulated into TAPP achieve combination chemotherapy chemodynamic therapy (CDT). Tmx directly downregulates HIF-1α, pillar[5]arene-based macrocyclic host successfully eliminates in tumors. Enhanced death achieved by Fe3+, therapeutic efficacy further synergized blockade (ICB) therapy. This reprogramming modality encourages cytotoxic T lymphocyte infiltration, achieving pre-eminent long-term suppression.
Язык: Английский
Процитировано
28