Antibiotic failure: Beyond antimicrobial resistance

Drug Resistance Updates, Год журнала: 2023, Номер 71, С. 101012 - 101012

Опубликована: Окт. 18, 2023

Язык: Английский

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Antibacterial smart hydrogels: New hope for infectious wound management

Materials Today Bio, Год журнала: 2022, Номер 17, С. 100499 - 100499

Опубликована: Ноя. 19, 2022

Millions of people die annually due to uncured wound infections. Healthcare systems incur high costs treat Tt is predicted become more challenging the rise multidrug-resistant conditions. During last decades, smart antibacterial hydrogels could attract attention as a promising solution, especially for skin These are termed 'smart' their response specific physical and chemical environmental stimuli. To deliver different drugs particular sites in controlled manner, various types crosslinking strategies used manufacturing process. Smart designed provide antimicrobial agents infected or built from polymers with inherent disinfectant properties. This paper aims critically review recent pre-clinical clinical advances using against infections propose next best thing future trends. For this purpose, an introduction healing disease presented intelligent responding stimuli introduced. Finally, most investigations discussed related sections. studies can pave way producing new biomaterials applications.

Язык: Английский

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Chitosan enhanced the stability and antibiofilm activity of self-propelled Prussian blue micromotor

Carbohydrate Polymers, Год журнала: 2022, Номер 299, С. 120134 - 120134

Опубликована: Сен. 21, 2022

Язык: Английский

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From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

ACS Infectious Diseases, Год журнала: 2023, Номер 9(3), С. 394 - 422

Опубликована: Фев. 15, 2023

In a previous development stage, mostly individual antibacterial activity was target in the optimization of biologically active compounds and antiseptic agents. Although this targeting is still valuable, new trend has appeared since discovery superhigh resistance bacterial cells upon their aggregation into groups. Indeed, it now well established that great majority pathogenic germs are found environment as surface-associated microbial communities called biofilms. The protective properties biofilms resistance, even to high concentrations biocides, cause many chronic infections medical settings lead serious economic losses various areas. A paradigm shift from also affecting more complex cellular frameworks taking place involves multiple strategies for combating with effective at different stages microbiome formation. Quaternary ammonium (QACs) play key role these treatments prophylactic techniques on basis both use agents combination technologies. review, we summarize literature data effectiveness using commercially available newly synthesized QACs, synergistic treatment based them. As an important focus, developing applying antimicrobial coatings prevent formation surfaces over time discussed. information analyzed review will be useful researchers engineers working fields, including generation applied materials; understanding biofilm surface growth; conducting research medical, pharmaceutical, materials sciences. regular studies widely conducted, promising evaluate antibiofilm comprehensive study order meet current requirements highly needed practical applications.

Язык: Английский

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Antibiotic‐Derived Carbon‐Nanodot‐Decorated Hydrogel for Reactive Oxygen Species‐Enhanced Anti‐Infection Through Biofilm Damage

Advanced Functional Materials, Год журнала: 2023, Номер 33(29)

Опубликована: Апрель 2, 2023

Abstract Irreversible bacterial resistance and impenetrable biofilms have rendered conventional antibiotic therapy ineffective. Nevertheless, increasing evidence has confirmed that carbon nanodots (CDs) exhibit potent antibacterial activity. However, the complex chemical composition of CDs, and, hence, their mechanism, is difficult to understand. The design new CDs against an urgent requirement.In this study, kanamycin‐sulfate‐derived (KCDs) are found significant potential with assistance light irradiation. Systematic analysis indicates KCDs not only retain active structure kanamycin but also produce five components modified on its surface, which shown inhibit activity Staphylococcus aureus beta‐ketoacyl‐acp synthase III (FabH) through molecular docking. Furthermore, multifunctional hydrogels (CG‐KCDs) self‐assemble into injectable, self‐healing, antibiofilm structures noncovalent forces between cationic guar gum (CG). results indicate under laser, CG‐KCDs irradiation exhibits enhanced in vitro by damaging a reactive oxygen species (ROS)‐dependent manner, as determined transcriptomics. Further, therapeutic effects hydrogel dressings wound healing tissue remodeling laser using vivo infection model. These validate efficient agents replace antibiotics anti‐infective strategy.

Язык: Английский

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Emerging Bioprinting for Wound Healing

Advanced Materials, Год журнала: 2023, Номер unknown

Опубликована: Авг. 11, 2023

Bioprinting has attracted much attention due to its suitability for fabricating biomedical devices. In particular, bioprinting become one of the growing centers in field wound healing, with various types bioprinted devices being developed, including 3D scaffolds, microneedle patches, and flexible electronics. Bioprinted can be designed specific biostructures biofunctions that closely match shape sites accelerate regeneration skin through approaches. Herein, a comprehensive review smart dressings is presented, emphasizing crucial effect determining biofunctions. The begins an overview techniques devices, followed in-depth discussion polymer-based inks, modification strategies, additive ingredients, properties, applications. strategies are divided into seven categories, chemical synthesis novel physical blending, coaxial bioprinting, multimaterial absorption, immobilization, hybridization living cells, examples presented. Thereafter, frontiers 4D artificial intelligence-assisted situ discussed from perspective interdisciplinary sciences. Finally, current challenges future prospects this highlighted.

Язык: Английский

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Current status and progress in research on dressing management for diabetic foot ulcer

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Авг. 17, 2023

Diabetic foot ulcer (DFU) is a major complication of diabetes and associated with high risk lower limb amputation mortality. During their lifetime, 19%–34% patients can develop DFU. It estimated that 61% DFU become infected 15% those require amputation. Furthermore, developing increases the mortality by 50%–68% at 5 years, higher than some cancers. Current standard management includes surgical debridement, use topical dressings wound decompression, vascular assessment, glycemic control. Among these methods, local treatment builds protective physical barrier, maintains moist environment, drains exudate from wounds. This review summarizes development, pathophysiology, healing mechanisms The latest research progress main application in laboratory clinical stage are also summarized. discussed this include traditional (gauze, oil yarn, Chinese medicine, others), basic (hydrogel, hydrocolloid, sponge, foam, film agents, bacteriostatic dressings, composite (collagen, nanomaterials, chitosan bioactive (scaffold stem cells, decellularized matrix, autologous platelet enrichment plasma, modern technology (3D bioprinting, photothermal effects, bioelectric microneedle smart bandages, orthopedic prosthetics regenerative medicine). dressing challenges limitations purpose to help readers understand pathogenesis mechanism DFU, physicians select correctly, provide an updated overview potential biomaterials devices management, ideas for further exploration development dressings. Proper promote healing, reduce cost treating patient pain.

Язык: Английский

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Biofilms in Chronic Wound Infections: Innovative Antimicrobial Approaches Using the In Vitro Lubbock Chronic Wound Biofilm Model

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(2), С. 1004 - 1004

Опубликована: Янв. 5, 2023

Chronic wounds have harmful effects on both patients and healthcare systems. Wound chronicity is attributed to an impaired healing process due several host local factors that affect pathways. The resulting ulcers contain a wide variety of microorganisms are mostly resistant antimicrobials possess the ability form mono/poly-microbial biofilms. search for new, effective safe compounds handle chronic has come long way throughout history medicine, which included studies trials conventional treatments. Treatments focus fighting microbial colonization develops in wound by multidrug pathogens. development molecular especially antibacterial agents, needs vitro model similar vivo environment evaluate efficacy antimicrobial agents. Lubbock biofilm (LCWB) developed mimic pathogen formation real wound, it suitable screen activity innovative compounds. In this review, we focused characteristics biofilms contribution LCWB study poly-microbial as novel treatment strategies.

Язык: Английский

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A Photo‐Therapeutic Nanocomposite with Bio‐Responsive Oxygen Self‐Supplying Combats Biofilm Infections and Inflammation from Drug‐Resistant Bacteria

Advanced Functional Materials, Год журнала: 2023, Номер 33(37)

Опубликована: Май 25, 2023

Abstract The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections, especially biofilms and accompanying inflammation, has recently aroused widespread interest. Herein, a photo‐therapeutic nanocomposite with bio‐responsive oxygen (O 2 ) self‐supplying is introduced by integrating manganese dioxide (MnO nanozymes onto photosensitizer (indocyanine green, ICG)‐loaded mesoporous polydopamine nanoparticles (MPDA), namely MI‐MPDA NPs. can activate O generation in the infection microenvironment, thereby effectively alleviating biofilm hypoxia. Under near‐infrared light (NIR) irradiation, continuous supplying further boosts level singlet ( 1 ), enabling robust elimination through ‐potentiated photodynamic/photothermal therapy. Interestingly, down‐regulates factor expression inflammatory signaling pathways MnO ‐mediated reactive species scavenging, which ameliorates condition. Meanwhile, prevents M1‐phenotype switch macrophages from overexpression hypoxia‐inducible factor‐1 α (HIF‐1 prompting macrophage reprogramming toward pro‐regenerative M2‐phenotype. In mouse models subcutaneous implant‐associated caused methicillin‐resistant Staphylococcus aureus (MRSA) burn Pseudomonas aeruginosa biofilms, NIR‐irradiated not only eliminates formed but also alleviates oxidative stress drives cascade reaction immunomodulation‐wound healing. Overall, this strategy provides reliable tool for combating infections inflammation bacteria.

Язык: Английский

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Chitosan‐Based Hydrogels as Antibacterial/Antioxidant/Anti‐Inflammation Multifunctional Dressings for Chronic Wound Healing

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(30)

Опубликована: Июль 22, 2024

Abstract Due to repeated microbial infection, persistent inflammation, excessive oxidative stress, and cell dysfunction, chronic wounds are difficult heal, posing a serious threat public health. Therefore, developing multifunctional wound dressings that can regulate the complex microenvironment of enhance cellular function holds great significance. Recently, chitosan has emerged as promising biopolymer for healing due its excellent biocompatibility, biodegradability, versatile bioactivity. The aim this review is provide comprehensive understanding mechanisms delayed discuss healing–promoting properties derivatives, such good antibacterial activity, hemostatic capacity, ability promote tissue regeneration. On basis, potential applications chitosan‐based hydrogels summarized in healing, including providing suitable microenvironment, eliminating bacterial infections, promoting hemostasis, inhibiting alleviating In addition, concerns perspectives clinical application also discussed.

Язык: Английский

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