ACS Nano,
Год журнала:
2024,
Номер
18(20), С. 13117 - 13129
Опубликована: Май 10, 2024
The
complexity,
heterogeneity,
and
drug
resistance
of
diseases
necessitate
a
shift
in
therapeutic
paradigms
from
monotherapy
to
combination
therapy,
which
could
augment
treatment
efficiency.
Effective
advanced
osteoarthritis
(OA)
requires
addressing
three
key
factors
contributing
its
deterioration:
chronic
joint
inflammation,
lubrication
dysfunction,
cartilage-tissue
degradation.
Herein,
we
present
supramolecular
nanomedicine
multifunctionality
via
molecular
recognition
self-assembly.
employed
macrocyclic
carrier,
zwitterion-modified
cavitand
(CV-2),
not
only
accurately
loads
various
drugs
but
also
functions
as
agent
with
lubricating
properties
for
the
OA.
Kartogenin
(KGN),
articular
cartilage
regeneration
protection,
flurbiprofen
(FP),
an
anti-inflammatory
agent,
were
coloaded
onto
CV-2
assembly,
forming
KGN&FP@CV-2.
three-in-one
therapy
KGN&FP@CV-2
addresses
pathological
features
treating
OA
collectively,
thus
provides
long-term
benefits
through
sustained
release
intrinsic
vivo.
multifunctional
integration
delivery
therapeutics
simple,
flexible,
universal
platform
synergistic
involving
multiple
drugs.
Advanced Materials,
Год журнала:
2023,
Номер
36(21)
Опубликована: Июль 21, 2023
Abstract
Chemotherapy
is
widely
recognized
as
an
effective
approach
for
treating
cancer
due
to
its
ability
eliminate
cells
using
chemotherapeutic
drugs.
However,
traditional
chemotherapy
suffers
from
various
drawbacks,
including
limited
solubility
and
stability
of
drugs,
severe
side
effects,
low
bioavailability,
drug
resistance,
challenges
in
tracking
treatment
efficacy.
These
limitations
greatly
hinder
widespread
clinical
application.
In
contrast,
supramolecular
chemotherapy,
which
relies
on
host–guest
interactions,
presents
a
promising
alternative
by
offering
highly
efficient
minimally
toxic
anticancer
delivery.
this
review,
overview
recent
advancements
based
interactions
provided.
The
significant
role
it
plays
guiding
therapy
emphasized.
Drawing
wealth
cutting‐edge
research,
herein,
timely
valuable
resource
individuals
interested
the
field
or
therapy,
presented.
Furthermore,
review
contributes
progression
toward
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(22), С. 7707 - 7736
Опубликована: Янв. 1, 2023
This
review
summarizes
the
strategies
to
engineer
CDT
nanocatalysts
based
on
diverse
nanocarriers,
especially
those
with
intrinsic
therapeutic
activities.
Advanced Materials,
Год журнала:
2024,
Номер
36(26)
Опубликована: Апрель 11, 2024
Drug
delivery
is
a
key
component
of
nanomedicine,
and
conventional
relies
on
the
adsorption
or
encapsulation
drug
molecules
to
nanomaterial.
Many
vehicles
contain
metal
ions,
such
as
metal-organic
frameworks,
oxides,
transition
dichalcogenides,
MXene,
noble
nanoparticles.
These
materials
have
high
content
pose
potential
long-term
toxicity
concerns
leading
difficulties
for
clinical
approval.
In
this
review,
recent
developments
are
summarized
in
use
ligands
coordination
forming
various
nanomaterials
soft
materials.
these
cases,
drug-to-metal
ratio
much
higher
than
adsorption-based
strategies.
The
divided
into
small-molecule
drugs,
nucleic
acids,
proteins.
formed
hybrid
mainly
include
nanoparticles
hydrogels,
upon
which
targeting
can
be
grafted
improve
efficacy
further
decrease
toxicity.
application
addressing
cancer,
viral
infection,
bacterial
infection
inflammatory
bowel
disease,
bone
diseases
reviewed.
end,
some
future
directions
discussed
from
fundamental
research,
science,
medicine.
Abstract
Although
immunotherapy
has
revolutionized
cancer
therapy
by
providing
efficient
tumor
growth
suppression,
long‐term
protection
from
recurrence
as
well
minimized
side
effects,
the
low
response
rate
significantly
limits
clinical
application
of
in
board
types
solid
tumors.
In
order
to
improve
therapeutic
efficacy,
conventional
therapies
including
radiotherapy,
chemotherapy,
phototherapy
and
chemodynamic
are
employed
combine
with
elicit
stronger
antitumor
immune
responses.
Polymer
nanomedicines
frequently
utilized
synergistic
other
owing
their
tunable
physiochemical
properties,
high
drug
loading
capacity,
ease
modification
toxicity.
With
elaborate
design
tailored
polymer
can
enhance
efficacy
enhancing
specificity,
priming
cells
amplifying
responses
However,
until
now,
there
is
no
review
solely
dedicated
comprehensive
development
polymer‐based
platforms
for
combinational
cancers.
Herein,
this
paper
summarizes
latest
advances
design,
fabrication
traditional
strategies
photothermal
therapy,
photodynamic
therapies.
An
outlook
on
trajectory
potential
challenges
bridging
gap
between
also
discussed.
Chemical Science,
Год журнала:
2024,
Номер
15(6), С. 1966 - 2006
Опубликована: Янв. 1, 2024
Neoplasias
pose
a
significant
threat
to
aging
society,
underscoring
the
urgent
need
overcome
limitations
of
traditional
chemotherapy
through
pioneering
strategies.
Targeted
drug
delivery
is
an
evolving
frontier
in
cancer
therapy,
aiming
enhance
treatment
efficacy
while
mitigating
undesirable
side
effects.
One
promising
avenue
utilizes
cell
membrane
receptors
like
folate
receptor
guide
transporters
precisely
malignant
cells.
Based
on
cellular
as
hallmark,
targeted
nanocarriers
and
small
molecule-drug
conjugates
have
been
developed
that
comprise
different
(bio)
chemistries
and/or
mechanical
properties
with
individual
advantages
challenges.
Such
modern
folic
acid-conjugated
stimuli-responsive
provide
systemic
controlled
release,
enabling
reduced
dosages,
circumvention
resistance,
diminished
adverse
Since
transporters'
structure-based
Abstract
Insufficient
tumor
immunogenicity
and
immune
escape
from
tumors
remain
common
problems
in
all
immunotherapies.
Recent
studies
have
shown
that
pyroptosis,
a
form
of
programmed
cell
death
is
accompanied
by
checkpoint
inhibitors,
can
induce
effective
immunogenic
long‐term
activation.
Therapeutic
strategies
to
jointly
pyroptosis
reverse
immunosuppressive
microenvironments
are
promising
for
cancer
immunotherapy.
In
this
regard,
dual‐responsive
supramolecular
polymeric
nanomedicine
(NCSNPs)
self‐cascade
amplify
the
benefits
immunotherapy
designed.
The
NCSNPs
formulated
β‐cyclodextrin
coupling
nitric
oxide
(NO)
donor,
activator,
NLG919,
an
indoleamine
2,3‐dioxygenase
(IDO)
inhibitor,
self‐assembled
through
host–guest
molecular
recognition
hydrophobic
interaction
obtain
nanoparticles.
possess
excellent
accumulation
bioavailability
attributed
ingenious
engineering.
study
not
only
confirms
occurrence
NO‐triggered
first
time
but
also
reverses
microenvironment
sites
via
IDO
inhibitor
enhancing
infiltration
cytotoxic
T
lymphocytes,
achieve
remarkable
inhibition
proliferation.
Thus,
provides
novel
strategy
