Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405

Опубликована: Июль 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Язык: Английский

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Molecular engineering of AIE-active boron clustoluminogens for enhanced boron neutron capture therapy

Chemical Science, Год журнала: 2024, Номер 15(11), С. 4019 - 4030

Опубликована: Янв. 1, 2024

This study presents a new type of boron carrier for neutron capture therapy that integrates imaging, lung cancer targeting drug and carborane, showcases an impressive therapeutic efficacy against tumors both in vitro vivo .

Язык: Английский

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Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated

Язык: Английский

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Development of organic photosensitizers for antimicrobial photodynamic therapy

Biomaterials Science, Год журнала: 2023, Номер 11(15), С. 5108 - 5128

Опубликована: Янв. 1, 2023

This review mainly summarises the recent progress in development of organic photosensitizers, including porphyrins, chlorophyll, phenothiazines, xanthenes and aggregation-induced emission for antimicrobial photodynamic therapy.

Язык: Английский

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Furan‐modified thiadiazolo quinoxaline as an electron acceptor for constructing second near‐infrared aggregation‐induced emission fluorophores for beyond 1300 nm fluorescence/photoacoustic imaging and photothermal therapy

Aggregate, Год журнала: 2023, Номер 5(2)

Опубликована: Ноя. 6, 2023

Abstract Creation of new fluorophores is important for understanding the structure–property relationship, by which required optical properties are likely to be attained. Herein, through theory calculation, it found that furan‐modified thiadiazolo quinoxaline acting as an electron acceptor can endow donor–acceptor–donor (D–A–D) type second near‐infrared (NIR‐II) with longer emission wavelength than other quinoxaline‐based acceptors containing pyridine, pyrrole, thiophene, and phenyl groups, respectively. On basis this theoretical prediction, a D–A–D NIR‐II fluorophore 6,7‐di(furan‐2‐yl)‐[1,2,5]thiadiazolo[3,4‐g] (DFTQ) dithieno[3,2‐b:2′,3′‐d]pyrrole (DTP) donor designed synthesized, aggregation‐induced (AIE) function further achieved introducing AIE units tetraphenylethylene (TPE) triphenylamine (TPA), respectively, totally forming three DFTQ–DTP, DFTQ–DTPE, DFTQ–DTPA. For biological applications, encapsulated amphiphilic DSPE–PEG 2000 generate water‐dispersible nanoparticles (NPs). Almost whole each NPs falls into spectral range, part beyond 1300 nm. By using DFTQ–DTPA contrast photothermal therapy (PTT) agent, high‐resolution in vivo fluorescence imaging greater nm window, their good performance photoacoustic high tumor PTT efficacy tumor‐bearing mice also demonstrated. Taken together, work mainly provides strong constructing long‐emitting fluorophores, acceptor, desirable quantum yield (QY) conversion efficienciy (PCE) synthesized demonstrated promising fluorescence/photoacoustic PTT.

Язык: Английский

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An Erythrocyte‐Templated Iron Single‐Atom Nanozyme for Wound Healing

Advanced Science, Год журнала: 2023, Номер 11(6)

Опубликована: Дек. 6, 2023

Abstract Iron single‐atom nanozymes represent a promising artificial enzyme with superior activity owing to uniform active sites that can precisely mimic center of nature enzymes. However, current synthetic strategies are hard guarantee each site at state. In this work, an erythrocyte‐templated strategy by utilizing intrinsic hemin hemoglobin as sing‐atom source for nanozyme formation is developed. By combining cell fixation, porous salinization, and high‐temperature carbonization, erythrocytes successfully served templates synthesize fully FeN 4 which derived from hemoglobin, resulting in enhanced peroxidase (POD)‐like activity. Interestingly, the catalytic (ETN) shows dependence on animal species, among murine ETN performed efficiency. addition, as‐prepared ETNs display honeycomb‐like network structure, serving sponge accelerate hemostasis based interactions prothrombin fibrinogen. These features enable effectively kill methicillin‐resistant Staphylococcus aureus (MRSA) POD‐like catalysis near‐infrared (NIR) induced photothermal effect, subsequently suitable promote wound healing. This study provides proof‐of‐concept facile fabrication multifunctional iron structure characteristics biogenic like erythrocytes.

Язык: Английский

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ROS‐Responsive Core‐Shell Microneedles Based on Simultaneous Efficient Type I/II Photosensitizers for Photodynamic Against Bacterial Biofilm Infections

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Abstract Antimicrobial photodynamic therapy (aPDT) has emerged as an appealing therapeutic option against biofilm infections. However, effectively penetrating the dense barrier of and anchoring bacteria to achieve elimination wound healing under hypoxic environments remains a challenge for aPDT. Herein, three type I/II Hypocrellin B (HB)‐cationic photosensitizers (HB‐P, HB‐TP, HB‐TTP) are designed based on multi‐cationic long chains molecular engineering strategy. With increasing number introduced cations, reactive oxygen species (ROS) production bacterial‐anchoring abilities HB‐cationic greatly enhanced. Notably, HB‐TTP demonstrates higher aPDT activity broad‐spectrum antibacterial properties. Furthermore, address conundrum biofilm‐infected wounds, ROS‐responsive core‐shell microneedle (HB‐TTP&EGF@MN) is by biphasically integrating growth factor. When penetrates biofilm, shell quickly dissolves releases removal laser irradiation. The core subsequently degraded slowly in presence endogenous ROS within wound, facilitating sustained release factor promote tissue regeneration. This work not only provides effective strategy rational design efficient antimicrobial agents but also proposes innovative ideas development controlled‐release pharmaceutical materials synergize

Язык: Английский

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Dual elemental doping activated signaling pathway of angiogenesis and defective heterojunction engineering for effective therapy of MRSA-infected wounds

Bioactive Materials, Год журнала: 2024, Номер 37, С. 14 - 29

Опубликована: Март 14, 2024

Multi-drug resistant bacterial infections pose a significant threat to human health. Thus, the development of effective bactericidal strategies is pressing concern. In this study, ternary heterostructure (Zn–CN/P-GO/BiS) comprised Zn-doped graphite phase carbon nitride (g-C3N4), phosphorous-doped graphene oxide (GO) and bismuth sulphide (Bi2S3) constructed for efficiently treating methicillin-resistant Staphylococcus aureus (MRSA)-infected wound. Zn doping-induced defect sites in g-C3N4 results reduced band gap (ΔE) smaller energy (ΔEST) between singlet state S1 triplet T1, which favours two-photon excitation accelerates electron transfer. Furthermore, formation an internal electric field at heterogeneous interface optimizes charge transfer pathway, inhibits recombination electron-hole pairs, improves photodynamic effect g-C3N4, enhances its catalytic performance. Therefore, Zn–CN/P-GO/BiS significantly augments production reactive oxygen species heat under 808 nm NIR (0.67 W cm−2) irradiation, leading elimination 99.60% ± 0.07% MRSA within 20 min. Additionally, release essential trace elements (Zn P) promotes wound healing by activating hypoxia-inducible factor-1 (HIF-1) peroxisome proliferator-activated receptors (PPAR) signaling pathways. This work provides unique insight into rapid antibacterial applications element doping excitation.

Язык: Английский

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Expanding Our Horizons: AIE Materials in Bacterial Research

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Abstract Bacteria share a longstanding and complex relationship with humans, playing role in protecting gut health sustaining the ecosystem to cause infectious diseases antibiotic resistance. Luminogenic materials that aggregation‐induced emission (AIE) characteristics have emerged as versatile toolbox for bacterial studies through fluorescence visualization. Numerous research efforts highlight superiority of AIE this field. Recent advances are categorized into four areas: understanding interactions, antibacterial strategies, diverse applications, synergistic applications bacteria. Initial focuses on visualizing unseen bacteria progresses developing strategies involving electrostatic amphiphilic luminogens (AIEgens), various enhance affinity. progress includes using photodynamic photothermal therapies, toxicity studies, combined therapies. Diverse from environmental disinfection disease treatment, utilizing coatings, sensors, wound healing materials, etc., also provided. Finally, combining achieve enhanced outcomes explored. This review summarizes developmental trend is expected provide future directions advancing methodologies.

Язык: Английский

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Cucurbit[8]uril-regulated face-to-face dimerization assembly enhanced photosensitization and photocatalysis

Science China Chemistry, Год журнала: 2024, Номер 67(5), С. 1605 - 1612

Опубликована: Апрель 12, 2024

Язык: Английский

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