Abstract
Aggregate‐level
photodynamic
therapy
(PDT)
has
attracted
significant
interest
and
driven
substantial
advances
in
multifunction
phototheranostic
platforms.
As
exemplified
by
two
typical
instances
of
aggregation‐caused
quenching
reactive
oxygen
species
(ROS)
aggregation‐induced
generation
ROS,
the
aggregation
effect
plays
a
role
on
ROS
photosensitizers
(PSs),
which
is
worthy
in‐depth
exploration
full
utilization.
However,
contrast
to
well‐developed
researches
luminescence,
studies
concerning
are
currently
relatively
nascent
disjointed
stage,
lacking
guidance
from
firmly
established
research
paradigm.
To
advance
this
regard,
review
aims
at
providing
consolidated
overview
fundamental
principles
status
effects
generation.
Here,
can
be
organized
into
main
facets.
One
involves
comparison
between
isolated
state
aggregated
state,
mainly
conducted
methods
changing
solvent
environments
adding
adjuvants
given
solvent.
The
other
underscores
distinctions
different
aggregate
states,
consisting
three
parts,
namely
within
same
or
categories
based
classification
single‐component
multicomponent
aggregates.
In
endeavor,
we
will
present
our
views
current
methodologies
that
explore
how
affects
highlight
design
strategies
leverage
optimize
PS
regiments.
We
aspire
propel
advancement
platforms
accelerate
clinical
implementation
precision
medicine,
inspire
more
contributions
aggregate‐level
photophysics
photochemistry,
pushing
science
materials
forward.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(29)
Опубликована: Март 19, 2024
Abstract
Controllable
protein
nanoarchitectonics
refers
to
the
process
of
manipulating
and
controlling
assembly
proteins
at
nanoscale
achieve
domain‐limited
accurate
spatial
arrangement.
In
nature,
many
undergo
precise
self‐assembly
with
other
structural
domains
engage
in
synergistic
physiological
activities.
Protein
nanomaterials
prepared
through
nanosizing
have
received
considerable
attention
due
their
excellent
biocompatibility,
low
toxicity,
modifiability,
versatility.
This
review
focuses
on
fundamental
strategies
used
for
controllable
nanoarchitectinics,
which
include
computational
design,
induction,
template
introduction,
complexation
chemical
modification,
vivo
assembly.
Precise
has
enabled
creation
nanostructures
different
dimensions,
including
0D
spherical
oligomers,
1D
nanowires,
nanorings,
nanotubes,
as
well
2D
nanofilms,
3D
nanocages.
The
unique
biological
properties
hold
promise
diverse
applications
these
nanomaterials,
biomedicine,
food
industry,
agriculture,
biosensing,
environmental
protection,
biocatalysis,
artificial
light
harvesting.
is
a
powerful
tool
developing
biomaterials
advanced
structures
functions.
Pharmaceutics,
Год журнала:
2024,
Номер
16(5), С. 670 - 670
Опубликована: Май 16, 2024
In
recent
years,
biopolymer-based
nano-drug
delivery
systems
with
antioxidative
properties
have
gained
significant
attention
in
the
field
of
pharmaceutical
research.
These
offer
promising
strategies
for
targeted
and
controlled
drug
while
also
providing
antioxidant
effects
that
can
mitigate
oxidative
stress-related
diseases.
Generally,
healthcare
landscape
is
constantly
evolving,
necessitating
continual
development
innovative
therapeutic
approaches
(DDSs).
DDSs
play
a
pivotal
role
enhancing
treatment
efficacy,
minimizing
adverse
effects,
optimizing
patient
compliance.
Among
these,
nanotechnology-driven
garnered
due
to
their
unique
properties,
such
as
improved
solubility,
release,
delivery.
Nanomaterials,
including
nanoparticles,
nanocapsules,
nanotubes,
etc.,
versatile
platforms
tissue
engineering
applications.
Additionally,
hold
immense
promise,
leveraging
natural
or
synthetic
biopolymers
encapsulate
drugs
enable
release.
numerous
advantages,
biocompatibility,
biodegradability,
low
immunogenicity.
The
utilization
polysaccharides,
polynucleotides,
proteins,
polyesters
biopolymer
matrices
further
enhances
versatility
applicability
DDSs.
Moreover,
substances
emerged
key
players
combating
diseases,
offering
protection
against
cellular
damage
chronic
illnesses.
nanoformulations
represents
burgeoning
research
area,
substantial
increase
publications
years.
This
review
provides
comprehensive
overview
developments
within
this
area
over
past
five
It
discusses
various
materials,
fabrication
techniques,
stabilizers,
factors
influencing
degradation,
it
highlights
emerging
trends,
challenges,
prospects
rapidly
evolving
field.
Advances in Colloid and Interface Science,
Год журнала:
2024,
Номер
331, С. 103242 - 103242
Опубликована: Июнь 24, 2024
Proteins
in
ionic
liquids
(ILs)
and
deep
eutectic
solvents
(DESs)
have
gained
significant
attention
due
to
their
potential
applications
various
fields,
including
biocatalysis,
bioseparation,
biomolecular
delivery,
structural
biology.
Scattering
approaches
dynamic
light
scattering
(DLS)
small-angle
X-ray
neutron
(SAXS
SANS)
been
used
understand
the
solution
behavior
of
proteins
at
nanoscale
microscale.
This
review
provides
a
thorough
exploration
application
these
techniques
elucidate
protein
properties
ILs
DESs.
Specifically,
begins
with
theoretical
foundations
relevant
describes
essential
solvent
DESs
linked
such
as
refractive
index,
length
density,
ion-pairs,
liquid
nanostructure,
aggregation,
specific
ion
effects.
Next,
detailed
introduction
is
provided
on
type,
concentration,
size,
flexibility
structure
observed
through
methodologies.
followed
by
literature
use
for
It
highlighted
that
enhanced
data
analysis
modeling
tools
are
necessary
assessing
structure,
understanding
hydration,
aggregation
also
noted
complementary
recommended
comprehensively
complex
interplay
factors,
ion-binding,
intermolecular
interactions,
Finally,
challenges
research
directions
this
field
proposed,
experimental
design,
approaches,
supporting
methods
obtain
fundamental
understandings
systems
solution.
We
envisage
will
support
further
studies
interface
science,
particular
effects
proteins.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(8), С. 1059 - 1059
Опубликована: Авг. 12, 2024
Inhaled
nanoparticle
(NP)
therapy
poses
intricate
challenges
in
clinical
and
pharmacodynamic
realms.
Recent
strides
have
revolutionized
NP
technology
by
enabling
the
incorporation
of
diverse
molecules,
thus
circumventing
systemic
clearance
mechanisms
enhancing
drug
effectiveness
while
mitigating
side
effects.
Despite
established
success
delivery
oncology
other
disciplines,
exploration
inhaled
therapies
remains
relatively
nascent.
NPs
loaded
with
bronchodilators
or
anti-inflammatory
agents
exhibit
promising
potential
for
precise
distribution
throughout
bronchial
tree,
offering
targeted
treatment
respiratory
diseases.
This
article
conducts
a
comprehensive
review
applications
medicine,
highlighting
their
merits,
ranging
from
heightened
stability
to
exacting
lung-specific
delivery.
It
also
explores
cutting-edge
technologies
optimizing
NP-loaded
aerosol
systems,
complemented
insights
gleaned
trials.
Furthermore,
examines
current
future
prospects
NP-based
therapies.
By
synthesizing
data
perspectives,
underscores
transformative
promise
NP-mediated
addressing
chronic
conditions
such
as
obstructive
pulmonary
disease,
pressing
global
health
concern
ranked
third
mortality
rates.
overview
illuminates
evolving
landscape
inhalation
therapies,
presenting
optimistic
avenues
advancing
medicine
improving
patient
outcomes.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Metal‐protein
hybrid
materials
represent
a
novel
class
of
functional
that
exhibit
exceptional
physicochemical
properties
and
tunable
structures,
rendering
them
remarkable
applications
in
diverse
fields,
including
engineering,
biocatalysis,
biosensing,
biomedicine.
The
design
development
multifunctional
biocompatible
metal‐protein
have
been
the
subject
extensive
research
key
aspiration
for
practical
clinical
settings.
This
review
provides
comprehensive
analysis
strategies,
intrinsic
properties,
biomedical
these
materials,
with
specific
emphasis
on
their
potential
cancer
therapy,
drug
vaccine
delivery,
antibacterial
treatments,
tissue
regeneration.
Through
rational
design,
stable
can
be
synthesized
using
straightforward
methods,
enabling
therapeutic,
immunomodulatory,
other
desired
functionalities.
Finally,
outlines
existing
limitations
challenges
associated
evaluates
translation,
providing
insights
into
implementation
within
applications.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7415 - 7471
Опубликована: Июль 1, 2024
Abstract:
Cancer,
as
the
foremost
challenge
among
human
diseases,
has
plagued
medical
professionals
for
many
years.
While
there
have
been
numerous
treatment
approaches
in
clinical
practice,
they
often
cause
additional
harm
to
patients.
The
emergence
of
nanotechnology
brought
new
directions
cancer
treatment,
which
can
deliver
anticancer
drugs
specifically
tumor
areas.
This
article
first
introduces
application
scenarios
nanotherapies
and
strategies
nanomedicine.
Then,
noteworthy
characteristics
exhibited
by
biopolymer
materials
were
described,
make
biopolymers
stand
out
polymeric
nanomedicine
delivery.
Next,
we
focus
on
summarizing
state-of-art
studies
five
categories
proteins
(Albumin,
Gelatin,
Silk
fibroin,
Zein,
Ferritin),
nine
varieties
polysaccharides
(Chitosan,
Starch,
Hyaluronic
acid,
Dextran,
cellulose,
Fucoidan,
Carrageenan,
Lignin,
Pectin)
liposomes
field
drug
Finally,
also
provide
a
summary
advantages
limitations
these
biopolymers,
discuss
prevailing
impediments
their
application,
detail
prospective
research
directions.
review
not
only
helps
readers
understand
current
development
status
nano
delivery
systems
based
but
is
helpful
properties
various
find
suitable
solutions
this
through
comparative
reading.
Keywords:
delivery,
nanoformulations,
polymer,
proteins,
Advanced Materials,
Год журнала:
2023,
Номер
36(13)
Опубликована: Ноя. 6, 2023
Abstract
Messenger
RNA
(mRNA)‐based
therapy
has
emerged
as
a
powerful,
safe,
and
rapidly
scalable
therapeutic
approach
that
involves
technologies
for
both
mRNA
itself
the
delivery
vehicle.
Although
there
are
some
unique
challenges
different
applications
of
therapy,
common
challenge
all
therapeutics
is
transport
into
target
cell
cytoplasm
sufficient
protein
expression.
This
review
focused
on
behaviors
at
cellular
level
nanotechnology‐mediated
systems,
which
have
not
been
comprehensively
reviewed
yet.
First,
four
main
introduced,
including
immunotherapy,
replacement
genome
editing,
reprogramming.
Second,
types
cargos
systems
summarized.
Third,
strategies
to
enhance
efficiency
during
trafficking
process
highlighted,
accumulation
cell,
internalization
endosomal
escape,
release
from
nanocarrier,
translation
protein.
Finally,
opportunities
development
presented.
can
provide
new
insights
future
fabrication
nanocarriers
with
desirable
performance.
Abstract
This
study
introduces
a
novel
dual‐targeting
drug
delivery
system
where
mitoxantrone
(MTO)
is
encapsulated
within
horse
spleen
apoferritin
(HsAFr)
nanocarriers,
modified
with
biotin
to
enhance
breast
cancer
targeting.
strategy
aims
increase
precision
and
efficacy
by
engaging
multiple
receptors
in
cells.
Structural
analyses
confirmed
that
the
encapsulation
surface
modification
preserved
protein
structure.
The
demonstrated
high
entrapment
efficiency
(91%)
notable
loading
(9.75%).
In
vitro,
HsAFr–MTO–Btn
complex
exhibited
greater
cytotoxicity
against
MCF‐7
cells
compared
free
MTO,
attributed
enhanced
cellular
uptake
apoptosis
through
caspase‐3
activation.
These
results
indicate
promising
approach
for
therapy,
potential
applications
other
difficult‐to‐treat
cancers.
