Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy

Aggregate, Journal Year: 2024, Volume and Issue: 5(4)

Published: March 10, 2024

Abstract Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching reactive oxygen species (ROS) aggregation‐induced generation ROS, the aggregation effect plays a role on ROS photosensitizers (PSs), which is worthy in‐depth exploration full utilization. However, contrast to well‐developed researches luminescence, studies concerning are currently relatively nascent disjointed stage, lacking guidance from firmly established research paradigm. To advance this regard, review aims at providing consolidated overview fundamental principles status effects generation. Here, can be organized into main facets. One involves comparison between isolated state aggregated state, mainly conducted methods changing solvent environments adding adjuvants given solvent. The other underscores distinctions different aggregate states, consisting three parts, namely within same or categories based classification single‐component multicomponent aggregates. In endeavor, we will present our views current methodologies that explore how affects highlight design strategies leverage optimize PS regiments. We aspire propel advancement platforms accelerate clinical implementation precision medicine, inspire more contributions aggregate‐level photophysics photochemistry, pushing science materials forward.

Language: Английский

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Metal‐Protein Hybrid Materials: Unlocking New Frontiers in Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.

Language: Английский

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A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 670 - 670

Published: May 16, 2024

In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These offer promising strategies for targeted and controlled drug while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, healthcare landscape is constantly evolving, necessitating continual development innovative therapeutic approaches (DDSs). DDSs play a pivotal role enhancing treatment efficacy, minimizing adverse effects, optimizing patient compliance. Among these, nanotechnology-driven garnered due to their unique properties, such as improved solubility, release, delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., versatile platforms tissue engineering applications. Additionally, hold immense promise, leveraging natural or synthetic biopolymers encapsulate drugs enable release. numerous advantages, biocompatibility, biodegradability, low immunogenicity. The utilization polysaccharides, polynucleotides, proteins, polyesters biopolymer matrices further enhances versatility applicability DDSs. Moreover, substances emerged key players combating diseases, offering protection against cellular damage chronic illnesses. nanoformulations represents burgeoning research area, substantial increase publications years. This review provides comprehensive overview developments within this area over past five It discusses various materials, fabrication techniques, stabilizers, factors influencing degradation, it highlights emerging trends, challenges, prospects rapidly evolving field.

Language: Английский

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Nanoparticle-Based Drug Delivery Systems in Inhaled Therapy: Improving Respiratory Medicine

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1059 - 1059

Published: Aug. 12, 2024

Inhaled nanoparticle (NP) therapy poses intricate challenges in clinical and pharmacodynamic realms. Recent strides have revolutionized NP technology by enabling the incorporation of diverse molecules, thus circumventing systemic clearance mechanisms enhancing drug effectiveness while mitigating side effects. Despite established success delivery oncology other disciplines, exploration inhaled therapies remains relatively nascent. NPs loaded with bronchodilators or anti-inflammatory agents exhibit promising potential for precise distribution throughout bronchial tree, offering targeted treatment respiratory diseases. This article conducts a comprehensive review applications medicine, highlighting their merits, ranging from heightened stability to exacting lung-specific delivery. It also explores cutting-edge technologies optimizing NP-loaded aerosol systems, complemented insights gleaned trials. Furthermore, examines current future prospects NP-based therapies. By synthesizing data perspectives, underscores transformative promise NP-mediated addressing chronic conditions such as obstructive pulmonary disease, pressing global health concern ranked third mortality rates. overview illuminates evolving landscape inhalation therapies, presenting optimistic avenues advancing medicine improving patient outcomes.

Language: Английский

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Scattering approaches to unravel protein solution behaviors in ionic liquids and deep eutectic solvents: From basic principles to recent developments

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 331, P. 103242 - 103242

Published: June 24, 2024

Proteins in ionic liquids (ILs) and deep eutectic solvents (DESs) have gained significant attention due to their potential applications various fields, including biocatalysis, bioseparation, biomolecular delivery, structural biology. Scattering approaches dynamic light scattering (DLS) small-angle X-ray neutron (SAXS SANS) been used understand the solution behavior of proteins at nanoscale microscale. This review provides a thorough exploration application these techniques elucidate protein properties ILs DESs. Specifically, begins with theoretical foundations relevant describes essential solvent DESs linked such as refractive index, length density, ion-pairs, liquid nanostructure, aggregation, specific ion effects. Next, detailed introduction is provided on type, concentration, size, flexibility structure observed through methodologies. followed by literature use for It highlighted that enhanced data analysis modeling tools are necessary assessing structure, understanding hydration, aggregation also noted complementary recommended comprehensively complex interplay factors, ion-binding, intermolecular interactions, Finally, challenges research directions this field proposed, experimental design, approaches, supporting methods obtain fundamental understandings systems solution. We envisage will support further studies interface science, particular effects proteins.

Language: Английский

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Protein‐Based Controllable Nanoarchitectonics for Desired Applications

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: March 19, 2024

Abstract Controllable protein nanoarchitectonics refers to the process of manipulating and controlling assembly proteins at nanoscale achieve domain‐limited accurate spatial arrangement. In nature, many undergo precise self‐assembly with other structural domains engage in synergistic physiological activities. Protein nanomaterials prepared through nanosizing have received considerable attention due their excellent biocompatibility, low toxicity, modifiability, versatility. This review focuses on fundamental strategies used for controllable nanoarchitectinics, which include computational design, induction, template introduction, complexation chemical modification, vivo assembly. Precise has enabled creation nanostructures different dimensions, including 0D spherical oligomers, 1D nanowires, nanorings, nanotubes, as well 2D nanofilms, 3D nanocages. The unique biological properties hold promise diverse applications these nanomaterials, biomedicine, food industry, agriculture, biosensing, environmental protection, biocatalysis, artificial light harvesting. is a powerful tool developing biomaterials advanced structures functions.

Language: Английский

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Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(13)

Published: Nov. 6, 2023

Abstract Messenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly scalable therapeutic approach that involves technologies for both mRNA itself the delivery vehicle. Although there are some unique challenges different applications of therapy, common challenge all therapeutics is transport into target cell cytoplasm sufficient protein expression. This review focused on behaviors at cellular level nanotechnology‐mediated systems, which have not been comprehensively reviewed yet. First, four main introduced, including immunotherapy, replacement genome editing, reprogramming. Second, types cargos systems summarized. Third, strategies to enhance efficiency during trafficking process highlighted, accumulation cell, internalization endosomal escape, release from nanocarrier, translation protein. Finally, opportunities development presented. can provide new insights future fabrication nanocarriers with desirable performance.

Language: Английский

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Biopolymer-Based Nanomedicine for Cancer Therapy: Opportunities and Challenges

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7415 - 7471

Published: July 1, 2024

Abstract: Cancer, as the foremost challenge among human diseases, has plagued medical professionals for many years. While there have been numerous treatment approaches in clinical practice, they often cause additional harm to patients. The emergence of nanotechnology brought new directions cancer treatment, which can deliver anticancer drugs specifically tumor areas. This article first introduces application scenarios nanotherapies and strategies nanomedicine. Then, noteworthy characteristics exhibited by biopolymer materials were described, make biopolymers stand out polymeric nanomedicine delivery. Next, we focus on summarizing state-of-art studies five categories proteins (Albumin, Gelatin, Silk fibroin, Zein, Ferritin), nine varieties polysaccharides (Chitosan, Starch, Hyaluronic acid, Dextran, cellulose, Fucoidan, Carrageenan, Lignin, Pectin) liposomes field drug Finally, also provide a summary advantages limitations these biopolymers, discuss prevailing impediments their application, detail prospective research directions. review not only helps readers understand current development status nano delivery systems based but is helpful properties various find suitable solutions this through comparative reading. Keywords: delivery, nanoformulations, polymer, proteins,

Language: Английский

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Polymer-mediated protein/peptide therapeutic stabilization: Current progress and future directions

Progress in Polymer Science, Journal Year: 2024, Volume and Issue: 156, P. 101867 - 101867

Published: Aug. 8, 2024

Language: Английский

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Nano-Food Farming: Toward Sustainable Applications of Proteins, Mushrooms, Nano-Nutrients, and Nanofibers

Agronomy, Journal Year: 2024, Volume and Issue: 14(3), P. 606 - 606

Published: March 18, 2024

The relationship between agriculture and food is very close. It impossible to produce adequate crops for global security without proper farm management. Farming practices represent direct indirect controlling factors in terms of security. management influence agro-food production from seed germination through the post-harvest treatments. Nano-farming utilizes nanotechnologies agricultural production. This review covers four key components nano-farming: nano-mushroom production, protein-based nanoparticles, nano-nutrients, nanofibers. provides a comprehensive overview potential applications nanotechnology agriculture. role these will be discussed relation challenges faced solutions required achieve sustainable Edible mushrooms are important because they nutritious source can nanoparticles that used other sources. Protein-based have considerable delivery bioactives as carriers applications. Nano-nutrients (mainly nano-selenium, nano-tellurium carbon nanodots) crucial impacts on nutrient status plant-based foods. Carbon nanodots carbon-based nanomaterials positively. There promising nanofibers packaging, safety processing. However, further research needed understand risks system.

Language: Английский

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