Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4392 - 4442

Опубликована: Янв. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Язык: Английский

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Augmenting Cancer Therapy with a Supramolecular Immunogenic Cell Death Inducer: A Lysosome-Targeted NIR-Light-Activated Ruthenium(II) Metallacycle

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(13), С. 8991 - 9003

Опубликована: Март 21, 2024

Though immunogenic cell death (ICD) has garnered significant attention in the realm of anticancer therapies, effectively stimulating strong immune responses with minimal side effects deep-seated tumors remains challenging. Herein, we introduce a novel self-assembled near-infrared-light-activated ruthenium(II) metallacycle, Ru1105 (λem = 1105 nm), as first example Ru(II) supramolecular ICD inducer. synergistically potentiates immunomodulatory and reduces adverse through multiple regulated approaches, including NIR-light excitation, increased reactive oxygen species (ROS) generation, selective targeting tumor cells, precision organelle localization, improved penetration/retention capabilities. Specifically, demonstrates excellent depth-activated ROS production (∼1 cm), resistance to diffusion, anti-ROS quenching. Moreover, exhibits promising results cellular uptake generation cancer cells multicellular spheroids. Importantly, induces more efficient an ultralow dose (10 μM) compared conventional agent, oxaliplatin (300 μM). In vivo experiments further confirm Ru1105's potency inducer, eliciting CD8+ T depleting Foxp3+ effects. Our research lays foundation for design secure exceptionally potent metal-based agents immunotherapy.

Язык: Английский

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Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Coordination Chemistry Reviews, Год журнала: 2024, Номер 505, С. 215677 - 215677

Опубликована: Янв. 31, 2024

Язык: Английский

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De Novo Designed Ru(II) Metallacycle as a Microenvironment‐Adaptive Sonosensitizer and Sonocatalyst for Multidrug‐Resistant Biofilms Eradication

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(15)

Опубликована: Фев. 8, 2024

Abstract Albeit sonodynamic therapy (SDT) has achieved encouraging progress in microbial sterilization, the scarcity of guidelines for designing highly effective sonosensitizers and intricate biofilm microenvironment (BME), substantially hamper therapeutic efficacy against infections. To address bottlenecks, we innovatively design a Ru(II) metallacycle‐based sonosensitizer/sonocatalyst (named Ru‐A3‐TTD ) to enhance potency sonotherapy by employing molecular engineering strategies tailored BME. Our approach involves augmenting ’s production ultrasonic‐triggered reactive oxygen species (ROS), surpassing performance commercial sonosensitizers, through straightforward but potent π‐expansion approach. Within BME, synergistically amplifies sonotherapeutic via triple‐modulated approaches: (i) alleviation hypoxia, leading increased ROS generation, (ii) disruption antioxidant defense system, which shields from glutathione consumption, (iii) enhanced penetration, enabling deep sites. Notably, sono‐catalytically oxidizes NADPH, critical coenzyme involved defenses. Consequently, demonstrates superior eradication multidrug‐resistant Escherichia coli compared conventional clinical antibiotics, both vitro vivo. our knowledge, this study represents pioneering instance supramolecular sonosensitizer/sonocatalyst. It provides valuable insights into structure‐activity relationship paves promising pathway treatment

Язык: Английский

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Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications

Chemical Society Reviews, Год журнала: 2024, Номер 53(6), С. 3167 - 3204

Опубликована: Янв. 1, 2024

We report strategies employed by metallacycle/metallacage-based supramolecular coordination complexes to enhance water solubility and biostability reduce potential toxicity side effects for biomedical applications.

Язык: Английский

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Supramolecular systems for bioapplications: recent research progress in China

Science China Chemistry, Год журнала: 2024, Номер 67(5), С. 1397 - 1441

Опубликована: Март 22, 2024

Язык: Английский

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Switchover from singlet oxygen to superoxide radical through a photoinduced two-step sequential energy transfer process

Chemical Science, Год журнала: 2024, Номер 15(5), С. 1870 - 1878

Опубликована: Янв. 1, 2024

We present an efficient method for the transformation of type II photosensitizers ( 1 O 2 ) into I (O ˙− through implementation artificial light-harvesting system involving a two-step sequential energy transfer process.

Язык: Английский

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A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

Aggregate, Год журнала: 2024, Номер 5(2)

Опубликована: Янв. 4, 2024

Abstract The development of efficient drug delivery systems is essential for improving the efficacy and safety cancer drugs, particularly aggressive difficult‐to‐treat cancers. Covalent organic frameworks (COFs) are emerging as innovative porous nanomaterials in (DDS), due to their unique properties, including metal‐free skeleton, predetermined structures pore geometries, high porosity, large surface area, facile modification potential, good biocompatibility. These characteristics make COFs excellent candidates by enhancing loading capacity enabling precise encapsulation. This review emphasizes importance donor‐acceptor‐based COFs, which provide channels charge transportation, we also explore how π‐conjugated skeleton enhances its long‐acting fluorescent properties facilitates uptake via cell endocytosis. While this primarily focuses on recent advancements COF‐based targeted DDS, it acknowledges challenges posed diverse geometries materials discusses potential solutions. Further, underlines developing future carriers that can successfully specifically target cells, treatment efficiency while reducing adverse side effects.

Язык: Английский

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The Midas Touch by Iridium: A Second Near-Infrared Aggregation-Induced Emission-Active Metallo-Agent for Exceptional Phototheranostics of Breast Cancer

Journal of the American Chemical Society, Год журнала: 2025, Номер 147(2), С. 2010 - 2020

Опубликована: Янв. 7, 2025

Developing small organic molecular phototheranostic agents with second near-infrared (NIR-II) aggregation-induced emission (AIE) is paramount for the phototriggered diagnostic imaging and synchronous in situ therapy of cancer via an excellent balance excited states energy dissipations. In this study, a multifunctional iridium(III) complex exploited by coordination AIE-active N^N ancillary ligand trivalent iridium ion. The resultant DPTPzIr significantly outperforms its parent terms absorption/emission wavelengths, reactive oxygen species (ROS) production, photothermal conversion, which simultaneously endow nanoparticles matched absorption peak to commercial 808 nm laser, longest NIR-II (above 1100 nm) among those previously reported AIE complexes, potentiated type-I ROS generation, as high 60.5% conversion efficiency. Consequently, perform well multimodal image-guided photodynamic therapy-photothermal breast tumor-bearing mice, enabling precise tumor diagnosis complete ablation biocompatibility. Our present work provides simple, feasible, effective paradigm development advanced agents.

Язык: Английский

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Guest-induced topological transformation and near-infrared photothermal conversion featuring the Cp*Rh unit via coordination-driven self-assembly

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Язык: Английский

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