Supramolecular assembly boosting the phototherapy performances of BODIPYs

Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 216054 - 216054

Опубликована: Июль 2, 2024

Язык: Английский

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A NIR‐Light‐Activated and Lysosomal‐Targeted Pt(II) Metallacycle for Highly Potent Evoking of Immunogenic Cell Death that Potentiates Cancer Immunotherapy of Deep‐Seated Tumors

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(37)

Опубликована: Май 22, 2024

Though platinum (Pt)-based complexes have been recently exploited as immunogenic cell death (ICD) inducers for activating immunotherapy, the effective activation of sufficient immune responses with minimal side effects in deep-seated tumors remains a formidable challenge. Herein, we propose first example near-infrared (NIR) light-activated and lysosomal targeted Pt(II) metallacycle (1) supramolecular ICD inducer. 1 synergistically potentiates immunomodulatory response via multiple-regulated approaches, involving NIR light excitation, boosted reactive oxygen species (ROS) generation, good selectivity between normal tumor cells, enhanced penetration/retention capabilities. Specifically, has excellent depth-activated ROS production (~7 mm), accompanied by strong anti-diffusion anti-ROS quenching ability. In vitro experiments demonstrate that exhibits significant cellular uptake generation cells well respective multicellular spheroids. Based on these advantages, induces more efficient an ultralow dose (i.e., 5 μM) compared clinical inducer-oxaliplatin (300 μM). vivo, vaccination further serves potent inducer through eliciting CD8

Язык: Английский

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Nitric Oxide‐Actuated Titanium Dioxide Janus Nanoparticles for Enhanced Multimodal Disruption of Infectious Biofilms

Advanced Functional Materials, Год журнала: 2024, Номер 34(45)

Опубликована: Июнь 28, 2024

Abstract Sonodynamic therapy (SDT) is promising for combating deep‐seated infectious diseases by generating substantial reactive oxygen species (ROS) through the profound tissue penetration capabilities of ultrasound. However, compact protective structures bacterial biofilms present a formidable challenge, impeding ROS efficacy. Given that have limited diffusion range and current sonosensitizers struggle to infiltrate biofilms, complete eradication pathogenic bacteria often remains unachieved. In this study, mesoporous titanium dioxide (TiO 2 ) nanoparticles are engineered asymmetrically coated with thin layer Ag loaded L‐arginine (LA) construct ultrasound‐propelled nanomotors. These Ag‐TiO ‐LA Janus demonstrate robust self‐propulsion upon ultrasonic activation, allowing deeper into biofilm matrices enhancing localized disruption improved SDT outcomes. Additionally, incorporation not only broadens TiO ’s absorption spectrum but also confers photothermal NIR laser excitation at 808 nm. The nanomotor amalgamates sonodynamic potential Ag's properties, forging versatile antimicrobial agent capable efficient synergistic antibacterial effect when subjected dual ultrasound stimuli. This innovative, singularly‐structured nanoparticle stands out as an effective combatant against accelerates healing process infected wounds, showcasing multifaceted clinical applications.

Язык: Английский

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An NIR Type I Photosensitizer Based on a Cyclometalated Ir(III)-Rhodamine Complex for a Photodynamic Antibacterial Effect toward Both Gram-Positive and Gram-Negative Bacteria

Inorganic Chemistry, Год журнала: 2024, Номер 63(28), С. 13059 - 13067

Опубликована: Июнь 28, 2024

Type I photosensitizers offer an advantage in photodynamic therapy (PDT) due to their diminished reliance on oxygen levels, thus circumventing the challenge of hypoxia commonly encountered PDT. In this study, we present synthesis and comprehensive characterization a novel type photosensitizer derived from cyclometalated Ir(III)-rhodamine complex. Remarkably, complex exhibits shift absorption fluorescence, transitioning "off" "on" states aprotic protic solvents, respectively, contrary initial expectations. Upon exposure light, demonstrates effective generation O2– ·OH radicals via mechanism. Additionally, it notable antibacterial activity against both Gram-positive Gram-negative bacteria, demonstrated through vitro vivo experiments. This research offers valuable insights for development photosensitizers.

Язык: Английский

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Biomimetic NIR-II Aggregation-Induced Emission Nanoparticles for Targeted Photothermal Therapy of Ovarian Cancer

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Photothermal therapy (PTT) is a cutting-edge technique that harnesses light energy and converts it into heat for precise tumor ablation. By employing photothermal agents to selectively generate target cancer cells, PTT has emerged as promising treatment strategy. Notably, therapies conducted in the second near-infrared (NIR-II) window exhibit superior therapeutic outcomes, owing deeper tissue penetration reduced scattering. In this study, we developed biomimetic NIR-II aggregation-induced emission (AIE) nanoparticles (2TB-NPs@TM) high-efficiency imaging targeted phototherapy of ovarian cancer. The core nanoparticle aggregates (2TB-NPs) display strong fluorescence high conversion efficiency, while outer cell membrane coating facilitates active targeting recognition tissues. This design imparts excellent biocompatibility enhances drug delivery leading potent synergistic effects. Our findings open new avenues advancing targeted, high-performance diagnostics treatment.

Язык: Английский

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Activatable Heavy-Atom-Free Photosensitizer with Large Stokes Shift and a NIR-II Emission Harnessing Rhodamine Ring-Opening Strategy

Analytical Chemistry, Год журнала: 2024, Номер 96(35), С. 14230 - 14238

Опубликована: Авг. 22, 2024

Activatable photosensitizers (PSs) generating

Язык: Английский

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Nanoparticle-mediated cell pyroptosis: a new therapeutic strategy for inflammatory diseases and cancer

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 22, 2024

Pyroptosis, a lytic form of cell death mediated by the gasdermin family, is characterized swelling and membrane rupture. Inducing pyroptosis in cancer cells can enhance antitumor immune responses promising strategy for therapy. However, excessive may trigger development inflammatory diseases due to immoderate continuous reactions. Nanomaterials nanobiotechnology, renowned their unique advantages diverse structures, have garnered increasing attention owing potential induce such as cancer. A nano-delivery system drug-induced overcome limitations small molecules. Furthermore, nanomedicines directly manipulate pyroptosis. This review summarizes discusses latest advancements nanoparticle-based treatments with among cancer, focusing on functions mechanisms providing valuable insights into selecting nanodrugs clinical application these strategies still faces challenges limited understanding nanobiological interactions. Finally, future perspectives emerging field pyroptotic nanomaterials are presented.

Язык: Английский

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Self-adaptive photodynamic therapy for boosting therapeutic efficiency in tumor

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Язык: Английский

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“Mix‐and‐Match”: Self‐Sorting Assembly Governed Supramolecular Polymeric Nanomedicine for Boosting Combined Chemo/Phototherapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining chemo/phototherapy (CT/PT). The high‐fidelity H‐bonding modularity from privileged heterocomplementary diaminopyridine/5‐fluorouracil (DAP/FU) Hamilton wedge/barbiturate (HW/Ba) pairs, respectively enable precise spatial control binding interactions FPtF BPeB, in turn allowing process specific “mix‐and‐match” capability. To directly stimulate phototherapy BPeB via near‐infrared (NIR) light, spectral matched upconversion nanoparticles (UCNPs, β‐NaYF 4 :Yb,Er) are encapsulated simultaneously. As result, polymeric nanomicelles, i.e., F/B/U@PHDO, readily fabricated. Moreover, distinct association constant (Ka) DAP/FU (≈10 2 M −1 ) HW/Ba 4‐5 pairs reflect different strengths stabilities H‐bonds, thus endowing programmable dissociation, accompanied release through pH/thermal‐stimuli. Therapeutic regime appreciated outcomes ultimately accomplished combined CT/PT. opportunities offered design anticipated point new paradigm for therapy.

Язык: Английский

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Targeting Sub-Cellular Organelles for Boosting Precision Photodynamic Therapy

Chemical Communications, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Among various cancer treatment methods, photodynamic therapy has received significant attention due to its non-invasiveness and high efficiency in inhibiting tumour growth. Recently, specific organelle targeting photosensitizers have increasing interest their precise accumulation ability trigger organelle-mediated cell death signalling pathways, which greatly reduces the drug dosage, minimizes toxicity, avoids multidrug resistance, prevents recurrence. In this review, recent advances representative used targeted on organelles, specifically including endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, lysosomes, been comprehensively reviewed with a focus structure pathways. Furthermore, perspective future research potential challenges precision presented at end.

Язык: Английский

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