Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Nature
often
provides
invaluable
insights
into
technological
innovation
and
the
construction
of
nanomaterials.
Inspired
by
pitaya
fruit's
strategy
wrapping
seeds
within
its
pulp
to
enhance
seed
survival,
a
unique
nanocomposite
based
on
metal‐organic
framework
(MOF)‐encapsulated
CuS
nanoparticles
(NPs)
is
developed.
This
design
effectively
addresses
challenge
short
retention
time
afforded
NPs
for
therapeutic
imaging
purposes.
The
MOF
acts
as
“pitaya
pulp”
protecting
internal
(“pitaya
seeds”),
thereby
increasing
their
in
vivo.
system
exhibits
triple‐enzyme‐mimicking
activities
proposed
application
photoacoustic
magnetic
resonance
imaging‐guided
therapies,
including
chemodynamic
therapy,
photothermal
cuproptosis‐related
therapy.
exceptional
enzyme‐mimicking
superoxide
dismutase,
catalase,
peroxidase
not
only
produce
oxygen
alleviate
hypoxia
but
also
generate
reactive
species
(ROS)
storm
effective
tumor
destruction.
By
combining
these
multienzymatic
properties,
superior
performance,
Cu‐induced
cuproptosis,
nanozyme‐treated
mice
exhibited
an
84%
inhibition
growth—approximately
double
effect
observed
treated
with
alone.
study
presents
smart
integrating
modalities,
achieving
outcomes
precise
Abstract
Although
immunotherapy
has
revolutionized
cancer
therapy
by
providing
efficient
tumor
growth
suppression,
long‐term
protection
from
recurrence
as
well
minimized
side
effects,
the
low
response
rate
significantly
limits
clinical
application
of
in
board
types
solid
tumors.
In
order
to
improve
therapeutic
efficacy,
conventional
therapies
including
radiotherapy,
chemotherapy,
phototherapy
and
chemodynamic
are
employed
combine
with
elicit
stronger
antitumor
immune
responses.
Polymer
nanomedicines
frequently
utilized
synergistic
other
owing
their
tunable
physiochemical
properties,
high
drug
loading
capacity,
ease
modification
toxicity.
With
elaborate
design
tailored
polymer
can
enhance
efficacy
enhancing
specificity,
priming
cells
amplifying
responses
However,
until
now,
there
is
no
review
solely
dedicated
comprehensive
development
polymer‐based
platforms
for
combinational
cancers.
Herein,
this
paper
summarizes
latest
advances
design,
fabrication
traditional
strategies
photothermal
therapy,
photodynamic
therapies.
An
outlook
on
trajectory
potential
challenges
bridging
gap
between
also
discussed.
Abstract
The
function‐oriented
synthesis
of
polyoxometalate
(POM)
nanoclusters
has
become
an
increasingly
important
area
research.
Herein,
the
well‐known
broad‐spectrum
anticancer
drug
Ge‐132
which
contains
Ge
IV
as
potential
heteroatoms
and
carboxyl
coordination
sites,
is
introduced
to
POM
system,
leading
first
organogermanium
functionalized
−Sb
III
‐templating
nanocluster
Na
4
[H
2
N(CH
3
)
]
16
H
18
[Sm
(H
O)
12
W
O
14
Ge(CH
CH
COOH)]
[SbW
9
33
[Ge(CH
COOH)
SbW
15
54
·62H
(
1
).
An
unprecedented
templating
Dawson‐like
COOH)SbW
12−
building
block
discovered.
To
take
advantage
pharmaceutical
activity
such
organogermanium‐functionalized
cluster,
further
composited
with
gold
nanoparticles
(NPs)
prepare
−Au
NPs,
doubles
blood
circulation
time
‐based
nanodrug.
Efficient
separation
photogenerated
charges
in
NPs
largely
boosts
photothermal
conversion
efficiency
(PCE
=
55.0%),
nearly
2.1
times
that
either
single
26.7%)
or
Au
26.2%),
simultaneously
facilitate
generation
toxic
activate
reactive
oxygen
species
tumor
microenvironment.
Based
on
these
findings,
it
demonstrated
are
a
multifunctional
renal
clearable
nanomedicine
great
photoacoustic
imaging
guiding
photothermal–chemodynamic
therapy
for
breast
cancer.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(41), С. 16355 - 16361
Опубликована: Окт. 7, 2024
Organic
photoelectrochemical
transistor
(OPECT)
has
emerged
as
a
promising
technique
for
biomolecule
detection,
yet
its
operational
rationale
remains
limited
due
to
short
development
time.
This
study
introduces
stable
tandem
catalysis
protocol
by
synergizing
the
enzyme-incorporated
metal-organic
frameworks
(E-MOFs)
with
polyoxometalate
(POM)
nanozyme
sensitive
OPECT
bioanalysis.
The
zeolitic
imidazolate
framework-8
(ZIF-8)
acts
skeleton
protect
encapsulated
glucose
oxidase
(GOx),
allowing
catalytic
generation
of
H
Polyoxometalates,
Год журнала:
2025,
Номер
4(1), С. 9140074 - 9140074
Опубликована: Март 1, 2025
In
recent
years,
polyoxometalates
have
been
systematically
studied
in
the
treatment
of
diabetes,
tumor,
cancer,
inflammation
and
other
diseases
vitro
vivo,
their
main
therapeutic
mechanisms
are
related
to
generation
reactive
oxygen
species
causing
oxidative
stress.
The
site
production
is
mitochondria,
therefore,
mechanism
may
be
mitochondrial
biosynthesis.
This
paper
describes
one
diabetes
mellitus,
which
involves
increase
species,
resulting
stress;
at
same
time,
preliminarily
as
antioxidants
antitumor
mellitus
tumors,
antioxidant
properties
provide
an
additional
possibility
for
future
a
drug
disease
treatment;
on
basis
study
stress
biomolecule
due
it,
associating
therapy
actually
closely
through
biosynthesis
regulation
relationship
between
mitochondria
its
impact
three
aspects
order
in-depth
role
drugs
aspects.
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 11, 2025
Biomolecular
motors
are
dynamic
systems
found
in
organisms
with
high
energy
conversion
efficiency.
FOF1-ATPase
is
a
rotary
biomolecular
motor
known
for
its
near
100%
It
utilizes
the
synthesis
and
hydrolysis
of
ATP
to
induce
conformational
changes
proteins,
thereby
converting
chemical
into
mechanical
motion.
Given
their
efficiency,
autonomous
propulsion
capability,
modifiable
structures,
have
attracted
significant
attention
potential
biomedical
applications.
This
Review
aims
introduce
detailed
structure
FOF1-ATPase,
explore
various
motility
manipulation
strategies,
summarize
applications
biological
detection
cargo
delivery.
Additionally,
innovative
research
methods
proposed
analyze
motion
mechanism
more
comprehensively,
goal
advancing
Finally,
this
concludes
key
insights
future
perspectives.
