Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Abstract
Thrombotic
cardiovascular
diseases
remain
the
leading
cause
of
mortality
worldwide.
However,
current
thrombolytic
therapeutics
suffer
from
limited
efficacy
and
a
high
risk
severe
bleeding.
Here,
phosphatidylcholine
liposome
accelerated
platinum
nanomachine
(PLANE)
for
thrombus
mechanotherapy
is
designed,
constructed
by
encapsulating
nanomotors
within
isotropic,
lubricating
(PC)
liposomes.
The
precisely
engineered
PLANE
exhibits
superior
lubricity
linear
motion.
Under
laser
irradiation
hydrogen
peroxide
treatment,
PLANEs
achieve
significantly
higher
velocities
than
conventional
nanomotors,
facilitating
deep
penetration
into
thrombi.
Further
functionalization
with
thrombus‐targeting
peptides
enables
cPLANEs
to
selectively
accumulate
at
thrombotic
sites
in
vivo,
demonstrating
excellent
efficacy.
This
work
presents
novel
surface
modification
strategy
optimizing
motion
behavior
offering
promising
non‐pharmaceutic
approach
disease
treatment.
Abstract
Although
immunotherapy
has
revolutionized
cancer
therapy
by
providing
efficient
tumor
growth
suppression,
long‐term
protection
from
recurrence
as
well
minimized
side
effects,
the
low
response
rate
significantly
limits
clinical
application
of
in
board
types
solid
tumors.
In
order
to
improve
therapeutic
efficacy,
conventional
therapies
including
radiotherapy,
chemotherapy,
phototherapy
and
chemodynamic
are
employed
combine
with
elicit
stronger
antitumor
immune
responses.
Polymer
nanomedicines
frequently
utilized
synergistic
other
owing
their
tunable
physiochemical
properties,
high
drug
loading
capacity,
ease
modification
toxicity.
With
elaborate
design
tailored
polymer
can
enhance
efficacy
enhancing
specificity,
priming
cells
amplifying
responses
However,
until
now,
there
is
no
review
solely
dedicated
comprehensive
development
polymer‐based
platforms
for
combinational
cancers.
Herein,
this
paper
summarizes
latest
advances
design,
fabrication
traditional
strategies
photothermal
therapy,
photodynamic
therapies.
An
outlook
on
trajectory
potential
challenges
bridging
gap
between
also
discussed.
Abstract
The
function‐oriented
synthesis
of
polyoxometalate
(POM)
nanoclusters
has
become
an
increasingly
important
area
research.
Herein,
the
well‐known
broad‐spectrum
anticancer
drug
Ge‐132
which
contains
Ge
IV
as
potential
heteroatoms
and
carboxyl
coordination
sites,
is
introduced
to
POM
system,
leading
first
organogermanium
functionalized
−Sb
III
‐templating
nanocluster
Na
4
[H
2
N(CH
3
)
]
16
H
18
[Sm
(H
O)
12
W
O
14
Ge(CH
CH
COOH)]
[SbW
9
33
[Ge(CH
COOH)
SbW
15
54
·62H
(
1
).
An
unprecedented
templating
Dawson‐like
COOH)SbW
12−
building
block
discovered.
To
take
advantage
pharmaceutical
activity
such
organogermanium‐functionalized
cluster,
further
composited
with
gold
nanoparticles
(NPs)
prepare
−Au
NPs,
doubles
blood
circulation
time
‐based
nanodrug.
Efficient
separation
photogenerated
charges
in
NPs
largely
boosts
photothermal
conversion
efficiency
(PCE
=
55.0%),
nearly
2.1
times
that
either
single
26.7%)
or
Au
26.2%),
simultaneously
facilitate
generation
toxic
activate
reactive
oxygen
species
tumor
microenvironment.
Based
on
these
findings,
it
demonstrated
are
a
multifunctional
renal
clearable
nanomedicine
great
photoacoustic
imaging
guiding
photothermal–chemodynamic
therapy
for
breast
cancer.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(41), С. 16355 - 16361
Опубликована: Окт. 7, 2024
Organic
photoelectrochemical
transistor
(OPECT)
has
emerged
as
a
promising
technique
for
biomolecule
detection,
yet
its
operational
rationale
remains
limited
due
to
short
development
time.
This
study
introduces
stable
tandem
catalysis
protocol
by
synergizing
the
enzyme-incorporated
metal-organic
frameworks
(E-MOFs)
with
polyoxometalate
(POM)
nanozyme
sensitive
OPECT
bioanalysis.
The
zeolitic
imidazolate
framework-8
(ZIF-8)
acts
skeleton
protect
encapsulated
glucose
oxidase
(GOx),
allowing
catalytic
generation
of
H
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Abstract
Triple‐negative
breast
cancer
has
an
immunologically
“cold”
microenvironment,
which
leads
to
resistance
current
immunotherapy.
The
activation
of
stimulator
interferon
genes
(STING)
pathway
been
thought
a
promising
strategy
enhance
immunotherapy
efficacy.
In
this
study,
we
adopted
comprehensive
that
integrates
innate
immune
responses
with
tumor‐targeting
photothermal
therapy
(PTT)
simultaneously
tackle
multiple
immune‐suppressive
mechanisms
in
cancer.
This
semiconducting
polymeric
nanoagonists
(DPTT‐Mn
Lipo
NPs)
mediated
PTT
can
effectively
initiate
tumor
cell
apoptosis
and
induce
ICD,
thereby
reprogramming
the
immunosuppressive
TME
activating
STING.
We
confirmed
modulation
through
PTT‐mediated
ICD
effect
transactivation
cGAS‐STING
cells
due
released
dsDNA
via
such
as
macrophages
DCs.
Indeed,
DPTT‐Mn
NPs‐mediated
promoted
M1
polarization
tumor‐associated
macrophages,
augmented
T‐cell
infiltration,
facilitated
dendritic
(DC)
maturation,
regulated
type
I
factor
secretion,
leading
efficient
suppression.
Most
importantly,
combination
NPs‐based
checkpoint
blockade
(anti‐PD‐1)
elicit
long‐term
memory
besides
eradication.
Collectively,
nano‐system
systemically
activate
antitumor
immunity
STING
potentially
establish
against
recurrence.
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 11, 2025
Biomolecular
motors
are
dynamic
systems
found
in
organisms
with
high
energy
conversion
efficiency.
FOF1-ATPase
is
a
rotary
biomolecular
motor
known
for
its
near
100%
It
utilizes
the
synthesis
and
hydrolysis
of
ATP
to
induce
conformational
changes
proteins,
thereby
converting
chemical
into
mechanical
motion.
Given
their
efficiency,
autonomous
propulsion
capability,
modifiable
structures,
have
attracted
significant
attention
potential
biomedical
applications.
This
Review
aims
introduce
detailed
structure
FOF1-ATPase,
explore
various
motility
manipulation
strategies,
summarize
applications
biological
detection
cargo
delivery.
Additionally,
innovative
research
methods
proposed
analyze
motion
mechanism
more
comprehensively,
goal
advancing
Finally,
this
concludes
key
insights
future
perspectives.
