Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Abstract
Thrombotic
cardiovascular
diseases
remain
the
leading
cause
of
mortality
worldwide.
However,
current
thrombolytic
therapeutics
suffer
from
limited
efficacy
and
a
high
risk
severe
bleeding.
Here,
phosphatidylcholine
liposome
accelerated
platinum
nanomachine
(PLANE)
for
thrombus
mechanotherapy
is
designed,
constructed
by
encapsulating
nanomotors
within
isotropic,
lubricating
(PC)
liposomes.
The
precisely
engineered
PLANE
exhibits
superior
lubricity
linear
motion.
Under
laser
irradiation
hydrogen
peroxide
treatment,
PLANEs
achieve
significantly
higher
velocities
than
conventional
nanomotors,
facilitating
deep
penetration
into
thrombi.
Further
functionalization
with
thrombus‐targeting
peptides
enables
cPLANEs
to
selectively
accumulate
at
thrombotic
sites
in
vivo,
demonstrating
excellent
efficacy.
This
work
presents
novel
surface
modification
strategy
optimizing
motion
behavior
offering
promising
non‐pharmaceutic
approach
disease
treatment.
BMEMat,
Journal Year:
2024,
Volume and Issue:
2(2)
Published: Jan. 12, 2024
Abstract
Although
immunotherapy
has
revolutionized
cancer
therapy
by
providing
efficient
tumor
growth
suppression,
long‐term
protection
from
recurrence
as
well
minimized
side
effects,
the
low
response
rate
significantly
limits
clinical
application
of
in
board
types
solid
tumors.
In
order
to
improve
therapeutic
efficacy,
conventional
therapies
including
radiotherapy,
chemotherapy,
phototherapy
and
chemodynamic
are
employed
combine
with
elicit
stronger
antitumor
immune
responses.
Polymer
nanomedicines
frequently
utilized
synergistic
other
owing
their
tunable
physiochemical
properties,
high
drug
loading
capacity,
ease
modification
toxicity.
With
elaborate
design
tailored
polymer
can
enhance
efficacy
enhancing
specificity,
priming
cells
amplifying
responses
However,
until
now,
there
is
no
review
solely
dedicated
comprehensive
development
polymer‐based
platforms
for
combinational
cancers.
Herein,
this
paper
summarizes
latest
advances
design,
fabrication
traditional
strategies
photothermal
therapy,
photodynamic
therapies.
An
outlook
on
trajectory
potential
challenges
bridging
gap
between
also
discussed.
Dalton Transactions,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Recent
advances
in
polyoxometalate
(POM)-based
materials
with
biomedical
applications
indicate
significant
potential
the
therapeutic
field.
The
scientific
community
aims
to
advance
these
enhance
bioorthogonal
chemistry
of
POMs.
Small,
Journal Year:
2024,
Volume and Issue:
20(46)
Published: July 30, 2024
Abstract
The
function‐oriented
synthesis
of
polyoxometalate
(POM)
nanoclusters
has
become
an
increasingly
important
area
research.
Herein,
the
well‐known
broad‐spectrum
anticancer
drug
Ge‐132
which
contains
Ge
IV
as
potential
heteroatoms
and
carboxyl
coordination
sites,
is
introduced
to
POM
system,
leading
first
organogermanium
functionalized
−Sb
III
‐templating
nanocluster
Na
4
[H
2
N(CH
3
)
]
16
H
18
[Sm
(H
O)
12
W
O
14
Ge(CH
CH
COOH)]
[SbW
9
33
[Ge(CH
COOH)
SbW
15
54
·62H
(
1
).
An
unprecedented
templating
Dawson‐like
COOH)SbW
12−
building
block
discovered.
To
take
advantage
pharmaceutical
activity
such
organogermanium‐functionalized
cluster,
further
composited
with
gold
nanoparticles
(NPs)
prepare
−Au
NPs,
doubles
blood
circulation
time
‐based
nanodrug.
Efficient
separation
photogenerated
charges
in
NPs
largely
boosts
photothermal
conversion
efficiency
(PCE
=
55.0%),
nearly
2.1
times
that
either
single
26.7%)
or
Au
26.2%),
simultaneously
facilitate
generation
toxic
activate
reactive
oxygen
species
tumor
microenvironment.
Based
on
these
findings,
it
demonstrated
are
a
multifunctional
renal
clearable
nanomedicine
great
photoacoustic
imaging
guiding
photothermal–chemodynamic
therapy
for
breast
cancer.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(41), P. 16355 - 16361
Published: Oct. 7, 2024
Organic
photoelectrochemical
transistor
(OPECT)
has
emerged
as
a
promising
technique
for
biomolecule
detection,
yet
its
operational
rationale
remains
limited
due
to
short
development
time.
This
study
introduces
stable
tandem
catalysis
protocol
by
synergizing
the
enzyme-incorporated
metal-organic
frameworks
(E-MOFs)
with
polyoxometalate
(POM)
nanozyme
sensitive
OPECT
bioanalysis.
The
zeolitic
imidazolate
framework-8
(ZIF-8)
acts
skeleton
protect
encapsulated
glucose
oxidase
(GOx),
allowing
catalytic
generation
of
H
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 23, 2024
Abstract
Nature
often
provides
invaluable
insights
into
technological
innovation
and
the
construction
of
nanomaterials.
Inspired
by
pitaya
fruit's
strategy
wrapping
seeds
within
its
pulp
to
enhance
seed
survival,
a
unique
nanocomposite
based
on
metal‐organic
framework
(MOF)‐encapsulated
CuS
nanoparticles
(NPs)
is
developed.
This
design
effectively
addresses
challenge
short
retention
time
afforded
NPs
for
therapeutic
imaging
purposes.
The
MOF
acts
as
“pitaya
pulp”
protecting
internal
(“pitaya
seeds”),
thereby
increasing
their
in
vivo.
system
exhibits
triple‐enzyme‐mimicking
activities
proposed
application
photoacoustic
magnetic
resonance
imaging‐guided
therapies,
including
chemodynamic
therapy,
photothermal
cuproptosis‐related
therapy.
exceptional
enzyme‐mimicking
superoxide
dismutase,
catalase,
peroxidase
not
only
produce
oxygen
alleviate
hypoxia
but
also
generate
reactive
species
(ROS)
storm
effective
tumor
destruction.
By
combining
these
multienzymatic
properties,
superior
performance,
Cu‐induced
cuproptosis,
nanozyme‐treated
mice
exhibited
an
84%
inhibition
growth—approximately
double
effect
observed
treated
with
alone.
study
presents
smart
integrating
modalities,
achieving
outcomes
precise
