Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy DOI Creative Commons

Man Fang,

Lei Cao, Zhao Zhang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Abstract Non-small cell lung cancer (NSCLC) represents the most prevalent form of cancer, exerting a substantial impact on global health. Cisplatin-based chemotherapy is standard treatment for NSCLC, but resistance and severe side effects present significant clinical challenges. Recently, novel tetravalent platinum compounds have attracted interest. While numerous studies concentrate their functional modifications targeted delivery, tumor-induced frequently overlooked. Previous compound demonstrated antitumor activity, yet proved ineffective against cells exhibiting to cisplatin. In order enhance efficacy potential applications in glutathione (GSH)-responsive albumin nanoquadrivalent (HSA@Pt) been constructed. light previous research into drug conjugation, this study was develop combined chemo-immunotherapy approach. The HSA@Pt high low toxicity, with tumor accumulation. Furthermore, tetrathiomolybdate (TM) has exert synergistic inhibitory effect Cu2+ Transporting Beta Polypeptide (ATP7B) Programmed Death Ligand 1 (PD-L1), impede efflux, induce cellular stress, activate immunity. findings suggest HSA@Pt's use strategy enhancing utility established drugs through sensitization.

Язык: Английский

Photonic Nanomaterials for Wearable Health Solutions DOI Creative Commons
Taewoong Park, Jung Woo Leem, Young L. Kim

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract This review underscores the transformative potential of photonic nanomaterials in wearable health technologies, driven by increasing demands for personalized monitoring. Their unique optical and physical properties enable rapid, precise, sensitive real‐time monitoring, outperforming conventional electrical‐based sensors. Integrated into ultra‐thin, flexible, stretchable formats, these materials enhance compatibility with human body, enabling prolonged wear, improved efficiency, reduced power consumption. A comprehensive exploration is provided integration devices, addressing material selection, light‐matter interaction principles, device assembly strategies. The highlights critical elements such as form factors, sensing modalities, data communication, representative examples skin patches contact lenses. These devices precise monitoring management biomarkers diseases or biological responses. Furthermore, advancements approaches have paved way continuum care systems combining multifunctional sensors therapeutic drug delivery mechanisms. To overcome existing barriers, this outlines strategies design, engineering, system integration, machine learning to inspire innovation accelerate adoption next‐generation health, showcasing their versatility digital applications.

Язык: Английский

Процитировано

1
Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy DOI Creative Commons

Man Fang,

Lei Cao, Zhao Zhang

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 18, 2025

Non-small cell lung cancer (NSCLC) represents the most prevalent form of cancer, exerting a substantial impact on global health. Cisplatin-based chemotherapy is standard treatment for NSCLC, but resistance and severe side effects present significant clinical challenges. Recently, novel tetravalent platinum compounds have attracted interest. While numerous studies concentrate their functional modifications targeted delivery, tumor-induced frequently overlooked. Previous compound demonstrated antitumor activity, yet proved ineffective against cells exhibiting to cisplatin. In order enhance efficacy potential applications in glutathione (GSH)-responsive albumin nanoquadrivalent (HSA@Pt) been constructed. light previous research into drug conjugation, this study was develop combined chemo-immunotherapy approach. The HSA@Pt high low toxicity, with tumor accumulation. Furthermore, Ammonium Tetrathiomolybdate (TM) has exert synergistic inhibitory effect ATPase Copper Transporting Beta (ATP7B) Programmed Death Ligand 1 (PD-L1), impede efflux, induce cellular stress, activate immunity. findings suggest HSA@Pt's use strategy enhancing utility established drugs through sensitization.

Язык: Английский

Процитировано

0
Individual ZnO–Ag Hybrid Nanorods for Synergistic Fluorescence Enhancement Towards Highly Sensitive and Miniaturized Biodetection DOI Creative Commons
Marion Ryan C. Sytu, Jong‐in Hahm

Nanomaterials, Год журнала: 2025, Номер 15(8), С. 617 - 617

Опубликована: Апрель 17, 2025

Hybrid nanostructures can be engineered to exhibit superior functionality beyond the level attainable from each of constituent nanomaterials by synergistically integrating their unique properties. In this work, we designed individual hybrid nanorods (NRs) ZnO–Ag in different heterojunction configurations where NR consists a single ZnO forming junction with Ag NR. We subsequently employed NRs fluorescence detection model chemical and biological analytes, rhodamine 6G (R6G), tumor necrosis factor-α (TNF-α), that undergo simple as well more complex immunoreaction steps on NRs. determine how parameters such analyte concentration, configuration, length influence signals, enhancement factors (EFs), changes EFs (%EFs) at positions provide much needed insights into capability systems using signal source located external Moreover, identify key consideration are critical design optimization platform for achieving high enhancements. show higher consistently observed relative other given NR, end–end configurations, longer than shorter Our research efforts demonstrate synergistic interplay two component escalates A surpassing those alone obtained Hence, our work further substantiates potential utility semiconductor-metal highly miniaturized ultra-trace detection, especially leveraging achieve capability.

Язык: Английский

Процитировано

0
Unlocking the Potential of CO2 Capture: A Synergistic Hybridization Strategy for Polymeric Hydrogels with Tunable Physicochemical Properties DOI Creative Commons

Yucong Gu,

Gaopeng Wang,

Xuanzhou Chen

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Май 20, 2024

Unlocking CO

Язык: Английский

Процитировано

3
A direct FE2 method for concurrent multilevel modeling of a coupled thermoelectric problem – Joule heating effect – in multiscale materials and structures DOI Creative Commons

Lu Meng,

Heng Zhang, Zhe Liu

и другие.

Thin-Walled Structures, Год журнала: 2024, Номер 203, С. 112166 - 112166

Опубликована: Июнь 26, 2024

Язык: Английский

Процитировано

3
A Multi‐functional Hybrid System Comprised of Polydopamine Nanobottles and Biological Effectors for Cartilage Repair DOI Creative Commons
Min Hao, Younan Xia

Small, Год журнала: 2024, Номер unknown

Опубликована: Июль 30, 2024

Abstract Biological effectors play critical roles in augmenting the repair of cartilage injuries, but it remains a challenge to control their release programmable, stepwise fashion. Herein, hybrid system consisting polydopamine (PDA) nanobottles embedded hydrogel matrix manage biological for use is reported. Specifically, homing effector load matrix, together with encapsulation PDA filled phase‐change material. In action, quickly released from initial step recruit stem cells surroundings. Owing antioxidation effect PDA, recruited are shielded reactive oxygen species. The then slowly promote chondrogenic differentiation, facilitating repair. Altogether, this strategy encompassing recruitment, protection, and differentiation offers viable route tissue or regeneration through cell therapy.

Язык: Английский

Процитировано

2
A WSe2 based hydrogel evaporator for water purification and solar desalination DOI

Shiqi Song,

Xiao Miao,

Yuan‐Han Yang

и другие.

Separation and Purification Technology, Год журнала: 2024, Номер 353, С. 128323 - 128323

Опубликована: Июнь 15, 2024

Язык: Английский

Процитировано

2
Site-Selective Functionalization of Outer Surface and Different Inner Spaces of Nanoscale Hierarchically Mesoporous MOFs for the Specific Detection of Cancer Cells DOI

Yuxin Zhou,

Jingwen Chen,

Fan Xia

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(15), С. 18006 - 18013

Опубликована: Июль 31, 2024

Spatial functionalization of hierarchically mesoporous metal–organic frameworks (HMMOFs) in a controllable manner is highly desirable yet challenging. Herein, microporous and spaces as well the external surface nanoscale UiO-66-NH2 MOFs were site-separately modified to endow them with additional functionalities. Given pore-filling effect soft templates, folic acid ligand was successfully grafted on outer without reducing pore size available volumes, making developed sensing nanoprobe competent specifically identify cancer cells. The support not only effectively protected encapsulated enzymes but also facilitated proximity between substrates by virtue spatial confinement effect. Cu2+ ions introduced skeleton could synergistically activate activity horseradish peroxidase immobilized mesopores. Thanks such enhanced enzymatic functionalities, designed quantitatively check out FR-overexpressed cells colorimetric visible way. Through deliberately screening different functionalities specific locations HMMOFs, model expected set guideline for design multiple-functional diagnostic platform detection various cancers.

Язык: Английский

Процитировано

1
Ternary heterojunction photocatalytic membranes with enhanced photogenerated electron transfer for improved fouling resistance and self-cleaning performance DOI
Zhenyu Fu, Zhenyou Dong, Qiuke Wang

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154425 - 154425

Опубликована: Июль 31, 2024

Язык: Английский

Процитировано

0
Spontaneous Macrophase Separation Strategy for Bridging Hydrogels from Bilayer to Double-Network Structure DOI
Dong Zhang, Qiang Chen, Hong Chen

и другие.

Accounts of Materials Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 4, 2024

Язык: Английский

Процитировано

0