Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy DOI Creative Commons

Man Fang,

Lei Cao, Zhao Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Abstract Non-small cell lung cancer (NSCLC) represents the most prevalent form of cancer, exerting a substantial impact on global health. Cisplatin-based chemotherapy is standard treatment for NSCLC, but resistance and severe side effects present significant clinical challenges. Recently, novel tetravalent platinum compounds have attracted interest. While numerous studies concentrate their functional modifications targeted delivery, tumor-induced frequently overlooked. Previous compound demonstrated antitumor activity, yet proved ineffective against cells exhibiting to cisplatin. In order enhance efficacy potential applications in glutathione (GSH)-responsive albumin nanoquadrivalent (HSA@Pt) been constructed. light previous research into drug conjugation, this study was develop combined chemo-immunotherapy approach. The HSA@Pt high low toxicity, with tumor accumulation. Furthermore, tetrathiomolybdate (TM) has exert synergistic inhibitory effect Cu2+ Transporting Beta Polypeptide (ATP7B) Programmed Death Ligand 1 (PD-L1), impede efflux, induce cellular stress, activate immunity. findings suggest HSA@Pt's use strategy enhancing utility established drugs through sensitization.

Language: Английский

Photonic Nanomaterials for Wearable Health Solutions DOI Creative Commons
Taewoong Park, Jung Woo Leem, Young L. Kim

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract This review underscores the transformative potential of photonic nanomaterials in wearable health technologies, driven by increasing demands for personalized monitoring. Their unique optical and physical properties enable rapid, precise, sensitive real‐time monitoring, outperforming conventional electrical‐based sensors. Integrated into ultra‐thin, flexible, stretchable formats, these materials enhance compatibility with human body, enabling prolonged wear, improved efficiency, reduced power consumption. A comprehensive exploration is provided integration devices, addressing material selection, light‐matter interaction principles, device assembly strategies. The highlights critical elements such as form factors, sensing modalities, data communication, representative examples skin patches contact lenses. These devices precise monitoring management biomarkers diseases or biological responses. Furthermore, advancements approaches have paved way continuum care systems combining multifunctional sensors therapeutic drug delivery mechanisms. To overcome existing barriers, this outlines strategies design, engineering, system integration, machine learning to inspire innovation accelerate adoption next‐generation health, showcasing their versatility digital applications.

Language: Английский

Citations

1
Blocking copper transporter protein-dependent drug efflux with albumin-encapsulated Pt(IV) for synergistically enhanced chemo-immunotherapy DOI Creative Commons

Man Fang,

Lei Cao, Zhao Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 18, 2025

Non-small cell lung cancer (NSCLC) represents the most prevalent form of cancer, exerting a substantial impact on global health. Cisplatin-based chemotherapy is standard treatment for NSCLC, but resistance and severe side effects present significant clinical challenges. Recently, novel tetravalent platinum compounds have attracted interest. While numerous studies concentrate their functional modifications targeted delivery, tumor-induced frequently overlooked. Previous compound demonstrated antitumor activity, yet proved ineffective against cells exhibiting to cisplatin. In order enhance efficacy potential applications in glutathione (GSH)-responsive albumin nanoquadrivalent (HSA@Pt) been constructed. light previous research into drug conjugation, this study was develop combined chemo-immunotherapy approach. The HSA@Pt high low toxicity, with tumor accumulation. Furthermore, Ammonium Tetrathiomolybdate (TM) has exert synergistic inhibitory effect ATPase Copper Transporting Beta (ATP7B) Programmed Death Ligand 1 (PD-L1), impede efflux, induce cellular stress, activate immunity. findings suggest HSA@Pt's use strategy enhancing utility established drugs through sensitization.

Language: Английский

Citations

0
Individual ZnO–Ag Hybrid Nanorods for Synergistic Fluorescence Enhancement Towards Highly Sensitive and Miniaturized Biodetection DOI Creative Commons
Marion Ryan C. Sytu, Jong‐in Hahm

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(8), P. 617 - 617

Published: April 17, 2025

Hybrid nanostructures can be engineered to exhibit superior functionality beyond the level attainable from each of constituent nanomaterials by synergistically integrating their unique properties. In this work, we designed individual hybrid nanorods (NRs) ZnO–Ag in different heterojunction configurations where NR consists a single ZnO forming junction with Ag NR. We subsequently employed NRs fluorescence detection model chemical and biological analytes, rhodamine 6G (R6G), tumor necrosis factor-α (TNF-α), that undergo simple as well more complex immunoreaction steps on NRs. determine how parameters such analyte concentration, configuration, length influence signals, enhancement factors (EFs), changes EFs (%EFs) at positions provide much needed insights into capability systems using signal source located external Moreover, identify key consideration are critical design optimization platform for achieving high enhancements. show higher consistently observed relative other given NR, end–end configurations, longer than shorter Our research efforts demonstrate synergistic interplay two component escalates A surpassing those alone obtained Hence, our work further substantiates potential utility semiconductor-metal highly miniaturized ultra-trace detection, especially leveraging achieve capability.

Language: Английский

Citations

0
Unlocking the Potential of CO2 Capture: A Synergistic Hybridization Strategy for Polymeric Hydrogels with Tunable Physicochemical Properties DOI Creative Commons

Yucong Gu,

Gaopeng Wang,

Xuanzhou Chen

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 20, 2024

Unlocking CO

Language: Английский

Citations

3
A direct FE2 method for concurrent multilevel modeling of a coupled thermoelectric problem – Joule heating effect – in multiscale materials and structures DOI Creative Commons

Lu Meng,

Heng Zhang, Zhe Liu

et al.

Thin-Walled Structures, Journal Year: 2024, Volume and Issue: 203, P. 112166 - 112166

Published: June 26, 2024

Language: Английский

Citations

3
A Multi‐functional Hybrid System Comprised of Polydopamine Nanobottles and Biological Effectors for Cartilage Repair DOI Creative Commons
Min Hao, Younan Xia

Small, Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract Biological effectors play critical roles in augmenting the repair of cartilage injuries, but it remains a challenge to control their release programmable, stepwise fashion. Herein, hybrid system consisting polydopamine (PDA) nanobottles embedded hydrogel matrix manage biological for use is reported. Specifically, homing effector load matrix, together with encapsulation PDA filled phase‐change material. In action, quickly released from initial step recruit stem cells surroundings. Owing antioxidation effect PDA, recruited are shielded reactive oxygen species. The then slowly promote chondrogenic differentiation, facilitating repair. Altogether, this strategy encompassing recruitment, protection, and differentiation offers viable route tissue or regeneration through cell therapy.

Language: Английский

Citations

2
A WSe2 based hydrogel evaporator for water purification and solar desalination DOI

Shiqi Song,

Xiao Miao,

Yuan‐Han Yang

et al.

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 353, P. 128323 - 128323

Published: June 15, 2024

Language: Английский

Citations

2
Site-Selective Functionalization of Outer Surface and Different Inner Spaces of Nanoscale Hierarchically Mesoporous MOFs for the Specific Detection of Cancer Cells DOI

Yuxin Zhou,

Jingwen Chen,

Fan Xia

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(15), P. 18006 - 18013

Published: July 31, 2024

Spatial functionalization of hierarchically mesoporous metal–organic frameworks (HMMOFs) in a controllable manner is highly desirable yet challenging. Herein, microporous and spaces as well the external surface nanoscale UiO-66-NH2 MOFs were site-separately modified to endow them with additional functionalities. Given pore-filling effect soft templates, folic acid ligand was successfully grafted on outer without reducing pore size available volumes, making developed sensing nanoprobe competent specifically identify cancer cells. The support not only effectively protected encapsulated enzymes but also facilitated proximity between substrates by virtue spatial confinement effect. Cu2+ ions introduced skeleton could synergistically activate activity horseradish peroxidase immobilized mesopores. Thanks such enhanced enzymatic functionalities, designed quantitatively check out FR-overexpressed cells colorimetric visible way. Through deliberately screening different functionalities specific locations HMMOFs, model expected set guideline for design multiple-functional diagnostic platform detection various cancers.

Language: Английский

Citations

1
Ternary heterojunction photocatalytic membranes with enhanced photogenerated electron transfer for improved fouling resistance and self-cleaning performance DOI
Zhenyu Fu, Zhenyou Dong, Qiuke Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154425 - 154425

Published: July 31, 2024

Language: Английский

Citations

0
Spontaneous Macrophase Separation Strategy for Bridging Hydrogels from Bilayer to Double-Network Structure DOI
Dong Zhang, Qiang Chen, Hong Chen

et al.

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 4, 2024

Language: Английский

Citations

0