Ovarian aging: energy metabolism of oocytes
Journal of Ovarian Research,
Год журнала:
2024,
Номер
17(1)
Опубликована: Май 31, 2024
Abstract
In
women
who
are
getting
older,
the
quantity
and
quality
of
their
follicles
or
oocytes
decline.
This
is
characterized
by
decreased
ovarian
reserve
function
(DOR),
fewer
remaining
oocytes,
lower
oocytes.
As
more
choose
to
delay
childbirth,
decline
in
fertility
associated
with
age
has
become
a
significant
concern
for
modern
women.
The
oocyte
key
indicator
aging.
Many
studies
suggest
that
age-related
changes
energy
metabolism
may
impact
quality.
Changes
affect
adenosine
5'-triphosphate
(ATP)
production,
but
how
related
products
proteins
influence
remains
largely
unknown.
review
focuses
on
aging
its
potential
quality,
as
well
therapeutic
strategies
partially
metabolism.
research
aims
enhance
our
understanding
metabolism,
identification
biomarkers
treatment
methods.
Язык: Английский
Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 9, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
multisystem
metabolic
disorder,
marked
by
abnormal
lipid
accumulation
and
intricate
inter-organ
interactions,
which
contribute
to
systemic
imbalances.
NAFLD
may
progress
through
several
stages,
including
simple
steatosis
(NAFL),
non-alcoholic
steatohepatitis
(NASH),
cirrhosis,
potentially
cancer.
This
closely
associated
with
disorders
driven
overnutrition,
key
pathological
processes
dysregulation,
impaired
autophagy,
mitochondrial
dysfunction,
endoplasmic
reticulum
(ER)
stress,
local
inflammation.
While
hepatic
metabolism
in
well-documented,
further
research
into
communication
mechanisms
crucial
for
deeper
understanding
of
progression.
review
delves
intrahepatic
networks
tissue-specific
signaling
mediators
involved
pathogenesis,
emphasizing
their
impact
on
distal
organs.
Язык: Английский
Role of Circulating microRNAs in Liver Disease and HCC: Focus on miR-122
Genes,
Год журнала:
2024,
Номер
15(10), С. 1313 - 1313
Опубликована: Окт. 12, 2024
miR-122
is
the
most
abundant
microRNA
(miRNA)
in
liver;
it
regulates
several
genes
mainly
involved
cell
metabolism
and
inflammation.
Host
factors,
diet,
metabolic
disorders
viral
infection
promote
development
of
liver
diseases,
including
hepatocellular
carcinoma
(HCC).
The
downregulation
tissue
a
common
feature
progression
injury.
In
addition,
release
bloodstream
seems
to
be
very
promising
for
early
diagnosis
both
non-viral
disease.
Although
controversial
data
are
available
on
role
circulating
as
single
biomarker,
high
diagnostic
accuracy
has
been
observed
using
combination
with
other
miRNAs
and/or
proteins.
This
review
focused
comprehensively
summarizing
recent
literature
potential
miR-122,
related
molecules,
biomarker(s)
hepatitis
HCC.
Язык: Английский
A panel of miRNAs in the serum extracellular vesicles serve as novel diagnostic biomarkers for MASLD
Biomedical Journal,
Год журнала:
2025,
Номер
unknown, С. 100838 - 100838
Опубликована: Фев. 1, 2025
The
increased
prevalence
of
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
and
its
profound
implications
for
global
health
have
sparked
extensive
research
endeavors
aimed
at
developing
potential
diagnostic
methods
this
condition.
Despite
the
achievements
in
defining
various
environmental
factors
genetic
predispositions
linked
to
MASLD,
diagnosis
clinical
staging
remain
challenging.
Recently,
extracellular
vesicles
(EVs)
garnered
considerable
attention
owing
their
roles
dysfunctions
as
biomarkers
conditions.
This
study
investigate
whether
microRNAs
(miRNAs)
serum
EVs
could
be
utilized
diagnosing
MASLD.
We
applied
an
innovative
efficient
approach
that
involves
capturing
analyzing
using
wheat
germ
agglutinin
(WGA)-coupled
magnetic
beads,
subsequently
employing
reverse
transcription
quantitative
polymerase
chain
reaction
(RT-qPCR)
analysis.
MiR-574-3p,
miR-542-3p,
miR-200a-3p
were
significantly
elevated
patients
with
indicating
markers.
has
established
a
straightforward
assay
platform
isolating
without
need
purification
quantitatively
detecting
miR-574-3p,
vesicles.
Язык: Английский
Extracellular vesicles derived microRNAs as non-invasive markers of liver fibrosis in chronically infected HCV patients: a pilot study
Non-coding RNA Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Extracellular
vesicles
(EVs)
are
an
increasingly
promising
tool
for
liquid
biopsy
in
liver
diseases.
Hepatitis
C
Virus
(HCV)
infection,
alone
or
together
with
Human
Immunodeficiency
(HIV)
infection
significantly
impacts
on
the
microRNA
(miRNA)
EVs
content
resembling
chronic
hepatitis
(CHC)
progression.
The
objective
of
study
was
to
delve
into
intricate
EVs-miRNA
profiles
CHC
patients
different
fibrosis
stages,
aiming
pinpoint
non-invasive
markers
capable
distinguishing
significant
fibrosis.
Plasma
EV-miRNAs
from
50
(HCV+
and
HCV+/HIV+)
stratified
no
(F
<
2)
≥
fibrosis,
were
massively
sequenced.
General
linear
models
(GLM)
used
identify
differential
expressed
(SDE)
miRNAs
according
stages
2
F
2).
Dysregulated
biological
pathways
subsequently
analyzed
silico
following
groups:
i)
all
patients;
ii)
HCV+;
iii)
HCV+/HIV+.
Multiple-ordered
logistic
regression
analysis
performed
develop
a
score
cases.
diagnostic
potential
both
SDE
developed
assessed
using
ROC
curve
analysis.
With
respect
patients,
two
(hsa-miR-122-5p
hsa-miR-92a-3p)
identified
which
regulate
genes
related
cytoskeleton
organization.
Regarding
their
performance
discriminate
2,
individually
demonstrated
acceptable
values.
However,
combined
use
new
enhanced
(AUROC
=
0.833).
In
HCV+
subgroup,
8
(hsa-miR-122-5p,
hsa-miR-320c,
hsa-miR-3615,
hsa-miR-320a-3p,
hsa-miR-374b-5p,
hsa-let-7a-3p,
hsa-miR-199a-5p,
hsa-miR-142-5p),
macrophage
activity
cell
growth/death
regulation,
recognized.
Among
them,
hsa-miR-3615
displayed
highest
0.936).
HCV+/HIV+,
18
(hsa-miR-4508,
hsa-miR-122-5p,
hsa-miR-451a,
hsa-miR-1290,
hsa-miR-1246,
hsa-miR-107,
hsa-miR-15b-5p,
hsa-miR-194-5p,
hsa-miR-22-5p,
hsa-miR-20b-5p,
hsa-miR-142-5p,
hsa-miR-328-3p,
hsa-miR-335-3p,
hsa-miR-125a-5p,
hsa-miR-423-3p,
hsa-let-7d-3p,
hsa-miR-128-3p,
hsa-miR-10a-5p)
recognized
that
RNA
silencing
processes.
this
case,
hsa-miR-423-3p
hsa-miR-128-3p
showed
outstanding
performances
>
0.900).
Distinct
varying
overall
cohort
within
HCV+/HIV+
subgroups.
These
specific
miRNA
signatures
would
allow
elucidation
mechanisms
involved
clinical
evolution
identification
biomarkers
unfavorable
progression,
plausible
be
panel.
Furthermore,
demonstrates
ability
group
those
individuals
regardless
HIV
status.
Язык: Английский
Recent advances and therapeutic applications of PPARγ-targeted ligands based on the inhibition mechanism of Ser273 phosphorylation
Metabolism,
Год журнала:
2024,
Номер
163, С. 156097 - 156097
Опубликована: Дек. 3, 2024
Язык: Английский
Lactic acid-fermented Sake lees protect against nonalcoholic steatohepatitis in mice
Functional Foods in Health and Disease,
Год журнала:
2024,
Номер
14(5), С. 334 - 345
Опубликована: Май 18, 2024
Background:
Nonalcoholic
steatohepatitis
(NASH)
is
a
common
disease
that
may
lead
to
hepatocellular
carcinoma
(HCC)
through
fatty
liver
and
cirrhosis.
Although
the
prevalence
of
NASH
increasing
worldwide,
there
no
cure
established
thus
far.
Sake
lees
are
by-product
sake
refining,
with
known
liver-protecting
effect.
Lactic
acid-fermented
(FSL)
food
produced
by
lactic
acid
fermentation
dealcoholization
lees.
This
product
commercially
available
in
Japan.
FSL
has
been
associated
numerous
functions,
far,
studies
have
not
investigated
its
hepatoprotective
Objectives:
The
objectives
this
study
evaluate
effects
mouse
model
NASH-HCC,
assess
impact
supplementation
on
blood
glucose
levels
mice
NASH,
analyze
expression
inflammatory
markers
FSL-fed
compared
controls,
determine
overall
efficacy
inhibiting
progression
NASH.
Methods:
For
study,
we
NASH-HCC.
Mice
were
placed
high-fat
diet
supplemented
from
10
14
weeks
age.
We
assessed
diet's
halting
control
group.
Results:
group
fed
exhibited
significant
suppression
notable
inhibition
Protein
analysis
revealed
reduction
controls.
Conclusion:
Ingestion
exert
anti-inflammatory
glucose-lowering
inhibit
progression.
Keywords:
anti-inflammation,
glucose,
liver,
Язык: Английский