Metabolism, Journal Year: 2024, Volume and Issue: 163, P. 156097 - 156097
Published: Dec. 3, 2024
Language: Английский
Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)
Published: May 31, 2024
Abstract In women who are getting older, the quantity and quality of their follicles or oocytes decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, lower oocytes. As more choose to delay childbirth, decline in fertility associated with age has become a significant concern for modern women. The oocyte key indicator aging. Many studies suggest that age-related changes energy metabolism may impact quality. Changes affect adenosine 5'-triphosphate (ATP) production, but how related products proteins influence remains largely unknown. review focuses on aging its potential quality, as well therapeutic strategies partially metabolism. research aims enhance our understanding metabolism, identification biomarkers treatment methods.
Language: Английский
Citations
10
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 9, 2025
Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, potentially cancer. This closely associated with disorders driven overnutrition, key pathological processes dysregulation, impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, local inflammation. While hepatic metabolism in well-documented, further research into communication mechanisms crucial for deeper understanding of progression. review delves intrahepatic networks tissue-specific signaling mediators involved pathogenesis, emphasizing their impact on distal organs.
Language: Английский
Citations
1
Biomedical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100838 - 100838
Published: Feb. 1, 2025
The increased prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and its profound implications for global health have sparked extensive research endeavors aimed at developing potential diagnostic methods this condition. Despite the achievements in defining various environmental factors genetic predispositions linked to MASLD, diagnosis clinical staging remain challenging. Recently, extracellular vesicles (EVs) garnered considerable attention owing their roles dysfunctions as biomarkers conditions. This study investigate whether microRNAs (miRNAs) serum EVs could be utilized diagnosing MASLD. We applied an innovative efficient approach that involves capturing analyzing using wheat germ agglutinin (WGA)-coupled magnetic beads, subsequently employing reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis. MiR-574-3p, miR-542-3p, miR-200a-3p were significantly elevated patients with indicating markers. has established a straightforward assay platform isolating without need purification quantitatively detecting miR-574-3p, vesicles.
Language: Английский
Citations
0
Non-coding RNA Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Extracellular vesicles (EVs) are an increasingly promising tool for liquid biopsy in liver diseases. Hepatitis C Virus (HCV) infection, alone or together with Human Immunodeficiency (HIV) infection significantly impacts on the microRNA (miRNA) EVs content resembling chronic hepatitis (CHC) progression. The objective of study was to delve into intricate EVs-miRNA profiles CHC patients different fibrosis stages, aiming pinpoint non-invasive markers capable distinguishing significant fibrosis. Plasma EV-miRNAs from 50 (HCV+ and HCV+/HIV+) stratified no (F < 2) ≥ fibrosis, were massively sequenced. General linear models (GLM) used identify differential expressed (SDE) miRNAs according stages 2 F 2). Dysregulated biological pathways subsequently analyzed silico following groups: i) all patients; ii) HCV+; iii) HCV+/HIV+. Multiple-ordered logistic regression analysis performed develop a score cases. diagnostic potential both SDE developed assessed using ROC curve analysis. With respect patients, two (hsa-miR-122-5p hsa-miR-92a-3p) identified which regulate genes related cytoskeleton organization. Regarding their performance discriminate 2, individually demonstrated acceptable values. However, combined use new enhanced (AUROC = 0.833). In HCV+ subgroup, 8 (hsa-miR-122-5p, hsa-miR-320c, hsa-miR-3615, hsa-miR-320a-3p, hsa-miR-374b-5p, hsa-let-7a-3p, hsa-miR-199a-5p, hsa-miR-142-5p), macrophage activity cell growth/death regulation, recognized. Among them, hsa-miR-3615 displayed highest 0.936). HCV+/HIV+, 18 (hsa-miR-4508, hsa-miR-122-5p, hsa-miR-451a, hsa-miR-1290, hsa-miR-1246, hsa-miR-107, hsa-miR-15b-5p, hsa-miR-194-5p, hsa-miR-22-5p, hsa-miR-20b-5p, hsa-miR-142-5p, hsa-miR-328-3p, hsa-miR-335-3p, hsa-miR-125a-5p, hsa-miR-423-3p, hsa-let-7d-3p, hsa-miR-128-3p, hsa-miR-10a-5p) recognized that RNA silencing processes. this case, hsa-miR-423-3p hsa-miR-128-3p showed outstanding performances > 0.900). Distinct varying overall cohort within HCV+/HIV+ subgroups. These specific miRNA signatures would allow elucidation mechanisms involved clinical evolution identification biomarkers unfavorable progression, plausible be panel. Furthermore, demonstrates ability group those individuals regardless HIV status.
Language: Английский
Citations
0
Genes, Journal Year: 2024, Volume and Issue: 15(10), P. 1313 - 1313
Published: Oct. 12, 2024
miR-122 is the most abundant microRNA (miRNA) in liver; it regulates several genes mainly involved cell metabolism and inflammation. Host factors, diet, metabolic disorders viral infection promote development of liver diseases, including hepatocellular carcinoma (HCC). The downregulation tissue a common feature progression injury. In addition, release bloodstream seems to be very promising for early diagnosis both non-viral disease. Although controversial data are available on role circulating as single biomarker, high diagnostic accuracy has been observed using combination with other miRNAs and/or proteins. This review focused comprehensively summarizing recent literature potential miR-122, related molecules, biomarker(s) hepatitis HCC.
Language: Английский
Citations
2
Functional Foods in Health and Disease, Journal Year: 2024, Volume and Issue: 14(5), P. 334 - 345
Published: May 18, 2024
Background: Nonalcoholic steatohepatitis (NASH) is a common disease that may lead to hepatocellular carcinoma (HCC) through fatty liver and cirrhosis. Although the prevalence of NASH increasing worldwide, there no cure established thus far. Sake lees are by-product sake refining, with known liver-protecting effect. Lactic acid-fermented (FSL) food produced by lactic acid fermentation dealcoholization lees. This product commercially available in Japan. FSL has been associated numerous functions, far, studies have not investigated its hepatoprotective Objectives: The objectives this study evaluate effects mouse model NASH-HCC, assess impact supplementation on blood glucose levels mice NASH, analyze expression inflammatory markers FSL-fed compared controls, determine overall efficacy inhibiting progression NASH. Methods: For study, we NASH-HCC. Mice were placed high-fat diet supplemented from 10 14 weeks age. We assessed diet's halting control group. Results: group fed exhibited significant suppression notable inhibition Protein analysis revealed reduction controls. Conclusion: Ingestion exert anti-inflammatory glucose-lowering inhibit progression. Keywords: anti-inflammation, glucose, liver,
Language: Английский
Citations
0
Metabolism, Journal Year: 2024, Volume and Issue: 163, P. 156097 - 156097
Published: Dec. 3, 2024
Language: Английский
Citations
0