Environmental Research, Год журнала: 2023, Номер 231, С. 116086 - 116086
Опубликована: Май 9, 2023
Язык: Английский
Environmental Research, Год журнала: 2023, Номер 231, С. 116316 - 116316
Опубликована: Июнь 1, 2023
Язык: Английский
Процитировано
174
Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(1)
Опубликована: Июнь 8, 2022
Urological cancers are among the most common malignancies around world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for treatment of although prognosis remains unfavorable. It is perceived that depends on an interdisciplinary approach combining biology engineering. The nanotechnological approaches introduced in various cancers, especially cancer. current review aims emphasize highlight possible applications nanomedicine eradication tumor. Nanoparticles can improve efficacy drugs therapy through elevating their bioavailability. potential genetic tools such as siRNA miRNA gene expression regulation be boosted using nanostructures by facilitating internalization accumulation at tumor sites cells. provide photodynamic photothermal ROS overgeneration hyperthermia, respectively, suppression Furthermore, remodeling microenvironment infiltration immune cells purpose immunotherapy achieved cargo-loaded nanocarriers. Nanocarriers mainly internalized endocytosis, proper design smart nanoparticles pH-, redox-, light-responsive nanocarriers importance targeted therapy. Bladder biomarkers detected timely diagnosis patients. Based site, they employed imaging. clinical translation challenges also covered review.
Язык: Английский
Процитировано
93
Pharmacological Research, Год журнала: 2022, Номер 187, С. 106553 - 106553
Опубликована: Ноя. 16, 2022
Cancer progression results from activation of various signaling networks. Among these, PI3K/Akt contributes to proliferation, invasion, and inhibition apoptosis. Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence rate, especially in regions prevalence viral hepatitis infection. Autoimmune disorders, diabetes mellitus, obesity, alcohol consumption, inflammation can also lead initiation development HCC. The treatment HCC depends on the identification oncogenic factors that tumor cells develop resistance therapy. present review article focuses role progression. Activation promotes glucose uptake, favors glycolysis increases cell proliferation. It inhibits both apoptosis autophagy while promoting survival. stimulates epithelial-to-mesenchymal transition (EMT) matrix-metalloproteinase (MMP) expression during metastasis. In addition increasing colony formation capacity facilitating spread cells, angiogenesis. Therefore, silencing prevents aggressive behavior. confer drug resistance, particularly sorafenib, decreases radio-sensitivity cells. Anti-cancer agents, like phytochemicals small molecules suppress by limiting Being upregulated tissues clinical samples, be used as biomarker predict patients' response
Язык: Английский
Процитировано
83
Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(2)
Опубликована: Ноя. 2, 2022
Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability sustained controlled release. To prolong NP circulation time, enable target‐specific overcome physiological barriers, NPs camouflaged in cell membranes have been developed evaluated to improve delivery. Here, we discuss recent advances membrane‐coated PLGA NPs, preparation methods, application cancer therapy, management inflammation, treatment cardiovascular disease control infection. We address the current challenges highlight future research directions needed effective use membrane‐camouflaged NPs.
Язык: Английский
Процитировано
82
Journal of Controlled Release, Год журнала: 2023, Номер 354, С. 503 - 522
Опубликована: Янв. 20, 2023
Язык: Английский
Процитировано
54
Separation and Purification Technology, Год журнала: 2023, Номер 310, С. 123193 - 123193
Опубликована: Янв. 17, 2023
Язык: Английский
Процитировано
50
ACS Applied Bio Materials, Год журнала: 2023, Номер 6(2), С. 784 - 792
Опубликована: Янв. 24, 2023
Radiation therapy has demonstrated promising effectiveness against several types of cancers. X-ray radiation can be made further effective by utilizing nanoparticles high-atomic-number (high-Z) materials that act as radiosensitizers. Here, in purpose maximizing the within tumors, bovine serum albumin capped gadolinium oxide and gold (Gd2O3@BSA-Au NPs) are developed a bimetallic radiosensitizer. In this study, we incorporate two high-Z-based nanoparticles, Au Gd, single nanoplatform. The radiosensitizing ability was assessed with series vitro tests, following evaluation vivo breast cancer murine model. Enhanced tumor suppression is observed group received after administration Gd2O3@BSA-Au NPs. As result, efficacy significantly improved applying NPs under irradiation, evidenced studies evaluating cell viability, proliferation, reactive oxygen species production, anti-tumor effect.
Язык: Английский
Процитировано
49
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 132579 - 132579
Опубликована: Май 23, 2024
Язык: Английский
Процитировано
35
Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 37, С. 101103 - 101103
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
23
Advances in Colloid and Interface Science, Год журнала: 2024, Номер 329, С. 103204 - 103204
Опубликована: Май 22, 2024
Язык: Английский
Процитировано
21