Nanotechnology-empowered strategies in treatment of skin cancer

Environmental Research, Год журнала: 2023, Номер 235, С. 116649 - 116649

Опубликована: Июль 13, 2023

Язык: Английский

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SOX2 function in cancers: Association with growth, invasion, stemness and therapy response

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 156, С. 113860 - 113860

Опубликована: Окт. 20, 2022

Язык: Английский

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Doxorubicin-loaded micelles in tumor cell-specific chemotherapy

Environmental Research, Год журнала: 2023, Номер 227, С. 115722 - 115722

Опубликована: Март 21, 2023

Язык: Английский

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A new formulation of Ni/Zn bi-metallic nanocomposite and evaluation of its applications for pollution removal, photocatalytic, electrochemical sensing, and anti-breast cancer

Environmental Research, Год журнала: 2023, Номер 233, С. 116462 - 116462

Опубликована: Июнь 22, 2023

Язык: Английский

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CuMoO4 nanorods-based acetone chemiresistor-enabled non-invasive breathomic-diagnosis of human diabetes and environmental monitoring

Environmental Research, Год журнала: 2023, Номер 229, С. 115931 - 115931

Опубликована: Апрель 17, 2023

Язык: Английский

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The bioengineered and multifunctional nanoparticles in pancreatic cancer therapy: Bioresponisive nanostructures, phototherapy and targeted drug delivery

Environmental Research, Год журнала: 2023, Номер 233, С. 116490 - 116490

Опубликована: Июнь 22, 2023

Язык: Английский

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Advanced multifunctional nano-lipid carrier loaded gel for targeted delivery of 5-flurouracil and cannabidiol against non-melanoma skin cancer

Environmental Research, Год журнала: 2023, Номер 233, С. 116454 - 116454

Опубликована: Июнь 19, 2023

Язык: Английский

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Molecular landscape of LncRNAs in bladder cancer: From drug resistance to novel LncRNA-based therapeutic strategies

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115242 - 115242

Опубликована: Июль 31, 2023

Bladder cancer (BC) is a common and serious type of that ranks among the top ten most prevalent malignancies worldwide. Due to high occurrence rate BC, aggressive nature cells, their resistance medication, managing this disease has become growing challenge in clinical care. Long noncoding RNAs (lncRNAs) are group RNA transcripts do not code for proteins more than 200 nucleotides length. They play significant role controlling cellular pathways molecular interactions during onset, development progression different types cancers. Recent advancements high-throughput gene sequencing technology have led identification various differentially expressed lncRNAs which indicate abnormal expression. In review, we summarize these been found impact several functions related including proliferation, cell growth, migration, metastasis, apoptosis, epithelial-mesenchymal transition, chemo- radio-resistance. Additionally, may improve prognosis prediction BC patients, indicating future use them as prognostic diagnostic biomarkers patients. This review highlights genetic tools anti-tumor agents, such CRISPR/Cas systems, siRNA, shRNA, antisense oligonucleotides, vectors, created preclinical models. interest using based on positive research findings.

Язык: Английский

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Co-delivery of doxorubicin/sorafenib by DNA-decorated green ZIF-67-based nanocarriers for chemotherapy and hepatocellular carcinoma treatment

Environmental Research, Год журнала: 2023, Номер 225, С. 115589 - 115589

Опубликована: Фев. 27, 2023

Zeolitic imidazolate framework-67 (ZIF-67) has been decorated with natural biomaterials and DNA to develop a promising strategy suitable safe co-delivery platform for doxorubicin sorafenib (DOX-SOR). FT-IR, XRD, FESEM, TEM were used characterize the modified MOFs. Combined Ginkgo biloba leaf extract E. coli as green decorations, environmentally-friendly methods be developed, DOX SOR attached porosity on surface of FESEM images demonstrated that MOFs successfully synthesized biomedical applications showed their cubic structure. As result nanocarrier-drug interactions, 59.7% 60.2% drug payload achieved SOR, respectively. HEK-293, HT-29, MCF-7 cells displayed excellent viability by decoration at low high concentrations (0.1 50 μg/mL), suggesting they could in applications. MTT assays nanocarriers are highly biocompatible normal possess anticancer properties when applied HT-29 cells. modification, DOX-SOR release was prolonged pH-sensitive (highest pHs 4.5 5.5). The internalization delivery also studied using 2d fluorescence microscope, demonstrating effectively internalized. Cell NPs internalizing cells, proving efficacy systems.

Язык: Английский

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Silver-Decorated and Silica-Capped Magnetite Nanoparticles with Effective Antibacterial Activity and Reusability

ACS Applied Bio Materials, Год журнала: 2023, Номер 6(6), С. 2266 - 2276

Опубликована: Июнь 5, 2023

Fruits are safe, toxin-free, and biomolecule-rich raw materials that may be utilized to decrease metal ions stabilize nanoparticles. Here, we demonstrate the green synthesis of magnetite nanoparticles which were first capped with a layer silica, followed by decoration silver nanoparticles, termed Ag@SiO2@Fe3O4, using lemon fruit extract as reducing agent in size range ∼90 nm. The effect stabilizer on characteristics was examined via different spectroscopy techniques, elemental composition multilayer-coated structures verified. saturation magnetization bare Fe3O4 at room temperature recorded 78.5 emu/g, whereas it decreased 56.4 43.8 emu/g for silica coating subsequent All displayed superparamagnetic behavior almost zero coercivity. While further processes, specific surface area increased from 67 180 m2 g–1 after addition reached 98 g–1, can explained organization an island-like model. Zeta potential values also −18 −34 mV coating, indicating enhanced stabilization silver. antibacterial tests against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus) revealed SiO2@Fe3O4 did not show sufficient effect, while even low concentrations (≤ 200 μg/mL), high activity due existence atoms Furthermore, vitro cytotoxicity assay Ag@SiO2@Fe3O4 toxic HSF-1184 cells μg/mL concentration. Antibacterial during consecutive magnetic separation recycling steps investigated, offered more than 10 cycles recycling, making them potentially useful biomedical fields.

Язык: Английский

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