Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
165, P. 115242 - 115242
Published: July 31, 2023
Bladder
cancer
(BC)
is
a
common
and
serious
type
of
that
ranks
among
the
top
ten
most
prevalent
malignancies
worldwide.
Due
to
high
occurrence
rate
BC,
aggressive
nature
cells,
their
resistance
medication,
managing
this
disease
has
become
growing
challenge
in
clinical
care.
Long
noncoding
RNAs
(lncRNAs)
are
group
RNA
transcripts
do
not
code
for
proteins
more
than
200
nucleotides
length.
They
play
significant
role
controlling
cellular
pathways
molecular
interactions
during
onset,
development
progression
different
types
cancers.
Recent
advancements
high-throughput
gene
sequencing
technology
have
led
identification
various
differentially
expressed
lncRNAs
which
indicate
abnormal
expression.
In
review,
we
summarize
these
been
found
impact
several
functions
related
including
proliferation,
cell
growth,
migration,
metastasis,
apoptosis,
epithelial-mesenchymal
transition,
chemo-
radio-resistance.
Additionally,
may
improve
prognosis
prediction
BC
patients,
indicating
future
use
them
as
prognostic
diagnostic
biomarkers
patients.
This
review
highlights
genetic
tools
anti-tumor
agents,
such
CRISPR/Cas
systems,
siRNA,
shRNA,
antisense
oligonucleotides,
vectors,
created
preclinical
models.
interest
using
based
on
positive
research
findings.
Environmental Research,
Journal Year:
2023,
Volume and Issue:
225, P. 115589 - 115589
Published: Feb. 27, 2023
Zeolitic
imidazolate
framework-67
(ZIF-67)
has
been
decorated
with
natural
biomaterials
and
DNA
to
develop
a
promising
strategy
suitable
safe
co-delivery
platform
for
doxorubicin
sorafenib
(DOX-SOR).
FT-IR,
XRD,
FESEM,
TEM
were
used
characterize
the
modified
MOFs.
Combined
Ginkgo
biloba
leaf
extract
E.
coli
as
green
decorations,
environmentally-friendly
methods
be
developed,
DOX
SOR
attached
porosity
on
surface
of
FESEM
images
demonstrated
that
MOFs
successfully
synthesized
biomedical
applications
showed
their
cubic
structure.
As
result
nanocarrier-drug
interactions,
59.7%
60.2%
drug
payload
achieved
SOR,
respectively.
HEK-293,
HT-29,
MCF-7
cells
displayed
excellent
viability
by
decoration
at
low
high
concentrations
(0.1
50
μg/mL),
suggesting
they
could
in
applications.
MTT
assays
nanocarriers
are
highly
biocompatible
normal
possess
anticancer
properties
when
applied
HT-29
cells.
modification,
DOX-SOR
release
was
prolonged
pH-sensitive
(highest
pHs
4.5
5.5).
The
internalization
delivery
also
studied
using
2d
fluorescence
microscope,
demonstrating
effectively
internalized.
Cell
NPs
internalizing
cells,
proving
efficacy
systems.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(6), P. 2266 - 2276
Published: June 5, 2023
Fruits
are
safe,
toxin-free,
and
biomolecule-rich
raw
materials
that
may
be
utilized
to
decrease
metal
ions
stabilize
nanoparticles.
Here,
we
demonstrate
the
green
synthesis
of
magnetite
nanoparticles
which
were
first
capped
with
a
layer
silica,
followed
by
decoration
silver
nanoparticles,
termed
Ag@SiO2@Fe3O4,
using
lemon
fruit
extract
as
reducing
agent
in
size
range
∼90
nm.
The
effect
stabilizer
on
characteristics
was
examined
via
different
spectroscopy
techniques,
elemental
composition
multilayer-coated
structures
verified.
saturation
magnetization
bare
Fe3O4
at
room
temperature
recorded
78.5
emu/g,
whereas
it
decreased
56.4
43.8
emu/g
for
silica
coating
subsequent
All
displayed
superparamagnetic
behavior
almost
zero
coercivity.
While
further
processes,
specific
surface
area
increased
from
67
180
m2
g–1
after
addition
reached
98
g–1,
can
explained
organization
an
island-like
model.
Zeta
potential
values
also
−18
−34
mV
coating,
indicating
enhanced
stabilization
silver.
antibacterial
tests
against
Escherichia
coli
(E.
coli)
Staphylococcus
aureus
(S.
aureus)
revealed
SiO2@Fe3O4
did
not
show
sufficient
effect,
while
even
low
concentrations
(≤
200
μg/mL),
high
activity
due
existence
atoms
Furthermore,
vitro
cytotoxicity
assay
Ag@SiO2@Fe3O4
toxic
HSF-1184
cells
μg/mL
concentration.
Antibacterial
during
consecutive
magnetic
separation
recycling
steps
investigated,
offered
more
than
10
cycles
recycling,
making
them
potentially
useful
biomedical
fields.
